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Protein

Zinc metalloproteinase-disintegrin-like 3a

Gene
N/A
Organism
Crotalus adamanteus (Eastern diamondback rattlesnake)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.By similarity

Miscellaneous

The disintegrin domain belongs to the long disintegrin subfamily.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi201Calcium 1By similarity1
Metal bindingi285Calcium 1By similarity1
Metal bindingi334Zinc; catalyticPROSITE-ProRule annotation1
Active sitei335PROSITE-ProRule annotation1
Metal bindingi338Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi344Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi389Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi392Calcium 1By similarity1
Metal bindingi404Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi407Calcium 2By similarity1
Metal bindingi411Calcium 2By similarity1
Metal bindingi414Calcium 2By similarity1
Metal bindingi417Calcium 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Protease, Toxin
LigandCalcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.320.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-disintegrin-like 3a (EC:3.4.24.-)
Alternative name(s):
Snake venom metalloproteinase
Short name:
SVMP
OrganismiCrotalus adamanteus (Eastern diamondback rattlesnake)
Taxonomic identifieri8729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000042562720 – 188By similarityAdd BLAST169
ChainiPRO_0000425628189 – 610Zinc metalloproteinase-disintegrin-like 3aAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 389By similarity
Disulfide bondi349 ↔ 373By similarity
Disulfide bondi351 ↔ 356By similarity
Disulfide bondi405 ↔ 434By similarity
Disulfide bondi416 ↔ 429By similarity
Disulfide bondi418 ↔ 424By similarity
Disulfide bondi428 ↔ 451By similarity
Disulfide bondi442 ↔ 448By similarity
Disulfide bondi447 ↔ 473By similarity
Disulfide bondi460 ↔ 480By similarity
Disulfide bondi467 ↔ 499By similarity
Disulfide bondi492 ↔ 504By similarity
Disulfide bondi511 ↔ 561By similarity
Disulfide bondi526 ↔ 572By similarity
Disulfide bondi539 ↔ 549By similarity
Disulfide bondi556 ↔ 598By similarity
Disulfide bondi592 ↔ 603By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliJ3S830.
SMRiJ3S830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 394Peptidase M12BPROSITE-ProRule annotationAdd BLAST197
Domaini402 – 488DisintegrinPROSITE-ProRule annotationAdd BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi466 – 468D/ECD-tripeptide3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi489 – 610Cys-richAdd BLAST122

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

J3S830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVLLVTIL AVFPYQGSSI ILGSGNVNDY EVVYPRKVTA LPKGAVQPKY
60 70 80 90 100
EDAMQYELKV NGEPMVLHLE KNKQLFSKDY SETHYSPDGR EITTYPLVED
110 120 130 140 150
HCYYHGRIEN DADSTASISA CNGLKGHFKL QGEIYLIEPL KLRDSEAHAV
160 170 180 190 200
FKYENVEKED EAPKMCGVTQ NWESYEPIKK ASQLVVTAEQ QRYLNPYRYV
210 220 230 240 250
ELVIVADHGM FTKYNRNLTE VKTWVYEIVN TLNEIYRYLY IRVALVGLEI
260 270 280 290 300
WSDGDLSNVT LSSGNTLDSF GEWRKRDLLR RKRHDNAQLL TAIDFSGNTI
310 320 330 340 350
GRASIANMCD PKYSTGIVQD HSPINLLVAV TMAHEMGHNL GLHHDGKSCT
360 370 380 390 400
CGDYICIMNA TLSHQHSKYF SNCSYNQYWD YINTYTPKCI LNEPLRTDII
410 420 430 440 450
SPPVCGNELL EAGEECDCGS PRNCQYQCCD AATCKLHSWV ECESGVCCEQ
460 470 480 490 500
CKFRTAGTEC RARRSECDIA ESCTGQSADC PTDDFHKNGQ PCLNNFGYCY
510 520 530 540 550
NGNCPIMYHQ CYALFGSNVY EAEDSCFESN QKGDDYGYCR KENGEKIPCA
560 570 580 590 600
PEDVKCGRLY CNDNSPGQND PCKIFPSNED EHKEMVLPGT KCADGKFCTN
610
GHCVDVATAY
Length:610
Mass (Da):68,840
Last modified:October 31, 2012 - v1
Checksum:i989717660103E466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU173712 mRNA. Translation: AFJ49238.1.

Similar proteinsi

Entry informationi

Entry nameiVM33_CROAD
AccessioniPrimary (citable) accession number: J3S830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: October 31, 2012
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families