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Protein
Submitted name:

Kalirin

Gene

KALRN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
KalirinImported
Gene namesi
Name:KALRNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4814. KALRN.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160145.

PTM / Processingi

Proteomic databases

MaxQBiJ3QSW6.
PeptideAtlasiJ3QSW6.
PRIDEiJ3QSW6.

Expressioni

Gene expression databases

BgeeiENSG00000160145.
ExpressionAtlasiJ3QSW6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliJ3QSW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 180CRAL-TRIOInterPro annotationAdd BLAST146
Domaini1281 – 1456DH (DBL-homology)InterPro annotationAdd BLAST176
Domaini1468 – 1580PHInterPro annotationAdd BLAST113
Domaini1646 – 1711SH3InterPro annotationAdd BLAST66
Domaini1929 – 2104DH (DBL-homology)InterPro annotationAdd BLAST176
Domaini2116 – 2226PHInterPro annotationAdd BLAST111
Domaini2471 – 2564Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST94
Domaini2571 – 2665Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini2684 – 2938Protein kinaseInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili919 – 946Sequence analysisAdd BLAST28

Sequence similaritiesi

Contains 2 PH domains.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119030.
KOiK15048.
OMAiGHSSELT.
OrthoDBiEOG091G00JY.
PhylomeDBiJ3QSW6.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 3 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF50729. SSF50729. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3QSW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR
60 70 80 90 100
DKRGGPILTF PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM
110 120 130 140 150
RGSKWDLIKP LLKTLQEAFP AEIHVALIIK PDNFWQKQKT NFGSSKFIFE
160 170 180 190 200
TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH EEWIELRLSL EEFFNSAVHL
210 220 230 240 250
LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA PVEELDREGQ
260 270 280 290 300
RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
310 320 330 340 350
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL
360 370 380 390 400
QTQHNHFAMN SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW
410 420 430 440 450
KSFAAALDER STILAMSAVF HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL
460 470 480 490 500
ELAIHHHQTL YEQVTQAYTE VSQDGKALLD VLQRPLSPGN SESLTATANY
510 520 530 540 550
SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV FQQDVQQVLD
560 570 580 590 600
WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA
610 620 630 640 650
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT
660 670 680 690 700
KELWTWMEDL QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE
710 720 730 740 750
GEDLIQQLRS APPSLGEPSE ARDSAVSNNK TPHSSSISHI ESVLQQLDDA
760 770 780 790 800
QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE VTAELDAWNE DLLRQMNDFN
810 820 830 840 850
TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT EVQASGIELI
860 870 880 890 900
CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK
910 920 930 940 950
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ
960 970 980 990 1000
KTHQSALQVQ QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK
1010 1020 1030 1040 1050
LVNASVAFYK TSEQVCSVLE SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP
1060 1070 1080 1090 1100
LISKHLEQKE AFLKACTLAR RNAEVFLKYI HRNNVSMPSV ASHTRGPEQQ
1110 1120 1130 1140 1150
VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK QALDWIQETG
1160 1170 1180 1190 1200
EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE
1210 1220 1230 1240 1250
KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL
1260 1270 1280 1290 1300
DIIPASLSDR EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL
1310 1320 1330 1340 1350
HECLETYLWE MTSGVEEIPP GILNKEHIIF GNIQEIYDFH NNIFLKELEK
1360 1370 1380 1390 1400
YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP DSNQLILEHA GTFFDEIQQR
1410 1420 1430 1440 1450
HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK DGLEVMLSVP
1460 1470 1480 1490 1500
KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL
1510 1520 1530 1540 1550
FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR
1560 1570 1580 1590 1600
TPSSDNKTVL KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP
1610 1620 1630 1640 1650
AKQRNNSKRD GVEDIDSQGD GSSQPDTISI ASRTSQNTVD SDKLSGGCEL
1660 1670 1680 1690 1700
TVVLQDFSAG HSSELTIQVG QTVELLERPS ERPGWCLVRT TERSPPLEGL
1710 1720 1730 1740 1750
VPSSALCISH SRSSVEMDCF FPLVKDAYSH SSSENGGKSE SVANLQAQPS
1760 1770 1780 1790 1800
LNSIHSSPGP KRSTNTLKKW LTSPVRRLNS GKADGNIKKQ KKVRDGRKSF
1810 1820 1830 1840 1850
DLGSPKPGDE TTPQGDSADE KSKKGWGEDE PDEESHTPLP PPMKIFDNDP
1860 1870 1880 1890 1900
TQDEMSSSLL AARQASTEVP TAADLVNAIE KLVKNKLSLE GSSYRGSLKD
1910 1920 1930 1940 1950
PAGCLNEGMA PPTPPKNPEE EQKAKALRGR MFVLNELVQT EKDYVKDLGI
1960 1970 1980 1990 2000
VVEGFMKRIE EKGVPEDMRG KDKIVFGNIH QIYDWHKDFF LAELEKCIQE
2010 2020 2030 2040 2050
QDRLAQLFIK HERKLHIYVW YCQNKPRSEY IVAEYDAYFE EVKQEINQRL
2060 2070 2080 2090 2100
TLSDFLIKPI QRITKYQLLL KDFLRYSEKA GLECSDIEKA VELMCLVPKR
2110 2120 2130 2140 2150
CNDMMNLGRL QGFEGTLTAQ GKLLQQDTFY VIELDAGMQS RTKERRVFLF
2160 2170 2180 2190 2200
EQIVIFSELL RKGSLTPGYM FKRSIKMNYL VLEENVDNDP CKFALMNRET
2210 2220 2230 2240 2250
SERVVLQAAN ADIQQAWVQD INQVLETQRD FLNALQSPIE YQRKERSTAV
2260 2270 2280 2290 2300
MRSQPARLPQ ASPRPYSSVP AGSEKPPKGS SYNPPLPPLK ISTSNGSPGF
2310 2320 2330 2340 2350
EYHQPGDKFE ASKQNDLGGC NGTSSMAVIK DYYALKENEI CVSQGEVVQV
2360 2370 2380 2390 2400
LAVNQQNMCL VYQPASDHSP AAEGWVPGSI LAPLTKATAA ESSDGSIKKS
2410 2420 2430 2440 2450
CSWHTLRMRK RAEVENTGKN EATGPRKPKD ILGNKVSVKE TNSSEESECD
2460 2470 2480 2490 2500
DLDPNTSMEI LNPNFIQEVA PEFLVPLVDV TCLLGDTVIL QCKVCGRPKP
2510 2520 2530 2540 2550
TITWKGPDQN ILDTDNSSAT YTVSSCDSGE ITLKICNLMP QDSGIYTCIA
2560 2570 2580 2590 2600
TNDHGTTSTS ATVKVQGVPA APNRPIAQER SCTSVILRWL PPSSTGNCTI
2610 2620 2630 2640 2650
SGYTVEYREE GSQIWQQSVA STLDTYLVIE DLSPGCPYQF RVSASNPWGI
2660 2670 2680 2690 2700
SLPSEPSEFV RLPEYDAAAD GATISWKENF DSAYTELNEI GRGRFSIVKK
2710 2720 2730 2740 2750
CIHKATRKDV AVKFVSKKMK KKEQAAHEAA LLQHLQHPQY ITLHDTYESP
2760 2770 2780 2790 2800
TSYILILELM DDGRLLDYLM NHDELMEEKV AFYIRDIMEA LQYLHNCRVA
2810 2820 2830 2840 2850
HLDIKPENLL IDLRIPVPRV KLIDLEDAVQ ISGHFHIHHL LGNPEFAAPE
2860 2870 2880 2890 2900
VIQGIPVSLG TDIWSIGVLT YVMLSGVSPF LDESKEETCI NVCRVDFSFP
2910 2920 2930 2940 2950
HEYFCGVSNA ARDFINVILQ EDFRRRPTAA TCLQHPWLQP HNGSYSKIPL
2960 2970 2980
DTSRLACFIE RRKHQNDVRP IPNVKSYIVN RVNQGT
Length:2,986
Mass (Da):340,261
Last modified:October 3, 2012 - v1
Checksum:iEA7B559A9E4AFFA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022336 Genomic DNA. No translation available.
AC069233 Genomic DNA. No translation available.
AC080008 Genomic DNA. No translation available.
AC112129 Genomic DNA. No translation available.
AC117401 Genomic DNA. No translation available.
KF457679 Genomic DNA. No translation available.
RefSeqiNP_001019831.2. NM_001024660.4.
UniGeneiHs.13281.
Hs.8004.

Genome annotation databases

EnsembliENST00000360013; ENSP00000353109; ENSG00000160145.
GeneIDi8997.
KEGGihsa:8997.
UCSCiuc003ehg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022336 Genomic DNA. No translation available.
AC069233 Genomic DNA. No translation available.
AC080008 Genomic DNA. No translation available.
AC112129 Genomic DNA. No translation available.
AC117401 Genomic DNA. No translation available.
KF457679 Genomic DNA. No translation available.
RefSeqiNP_001019831.2. NM_001024660.4.
UniGeneiHs.13281.
Hs.8004.

3D structure databases

ProteinModelPortaliJ3QSW6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiJ3QSW6.
PeptideAtlasiJ3QSW6.
PRIDEiJ3QSW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360013; ENSP00000353109; ENSG00000160145.
GeneIDi8997.
KEGGihsa:8997.
UCSCiuc003ehg.4. human.

Organism-specific databases

CTDi8997.
HGNCiHGNC:4814. KALRN.
OpenTargetsiENSG00000160145.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119030.
KOiK15048.
OMAiGHSSELT.
OrthoDBiEOG091G00JY.
PhylomeDBiJ3QSW6.

Miscellaneous databases

ChiTaRSiKALRN. human.
GenomeRNAii8997.

Gene expression databases

BgeeiENSG00000160145.
ExpressionAtlasiJ3QSW6. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 3 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF50729. SSF50729. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJ3QSW6_HUMAN
AccessioniPrimary (citable) accession number: J3QSW6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.