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Protein
Submitted name:

Solute carrier family 12 member 3

Gene

SLC12A3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 member 3Imported
Gene namesi
Name:SLC12A3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:10912. SLC12A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei137 – 15620HelicalSequence analysisAdd
BLAST
Transmembranei168 – 19326HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23825HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27720HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30520HelicalSequence analysisAdd
BLAST
Transmembranei339 – 36123HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39220HelicalSequence analysisAdd
BLAST
Transmembranei452 – 47322HelicalSequence analysisAdd
BLAST
Transmembranei505 – 52420HelicalSequence analysisAdd
BLAST
Transmembranei530 – 55122HelicalSequence analysisAdd
BLAST
Transmembranei585 – 60420HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiJ3QSS1.
PeptideAtlasiJ3QSS1.
PRIDEiJ3QSS1.

Expressioni

Gene expression databases

BgeeiENSG00000070915.
ExpressionAtlasiJ3QSS1. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiJ3QSS1. 1 interaction.
STRINGi9606.ENSP00000402152.

Structurei

3D structure databases

ProteinModelPortaliJ3QSS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 11570AA_permease_NInterPro annotationAdd
BLAST
Domaini140 – 645506AA_permeaseInterPro annotationAdd
BLAST
Domaini654 – 788135SLC12InterPro annotationAdd
BLAST
Domaini814 – 1019206SLC12InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR018491. SLC12_C.
IPR002948. SLC12A3.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF9. PTHR11827:SF9. 3 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01230. NACLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

J3QSS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELPTTETP GDATLCSGRF TISTLLSSDE PSPPAAYDSS HPSHLTHSST
60 70 80 90 100
FCMRTFGYNT IDVVPTYEHY ANSTQPGEPR KVRPTLADLH SFLKEGRHLH
110 120 130 140 150
ALAFDSRPSH EMTDGLVEGE AGTSSEKNPE EPVRFGWVKG VMIRCMLNIW
160 170 180 190 200
GVILYLRLPW ITAQAGIVLT WIIILLSVTV TSITGLSISA ISTNGKVKSG
210 220 230 240 250
GTYFLISRSL GPELGGSIGL IFAFANAVGV AMHTVGFAET VRDLLQEYGA
260 270 280 290 300
PIVDPINDIR IIAVVSVTVL LAISLAGMEW ESKAQVLFFL VIMVSFANYL
310 320 330 340 350
VGTLIPPSED KASKGFFSYR ADIFVQNLVP DWRGPDGTFF GMFSIFFPSA
360 370 380 390 400
TGILAGANIS GDLKDPAIAI PKGTLMAIFW TTISYLAISA TIGSCVVRDA
410 420 430 440 450
SGVLNDTVTP GWGACEGLAC SYGWNFTECT QQHSCHYGLI NYYQTMSMVS
460 470 480 490 500
GFAPLITAGI FGATLSSALA CLVSAAKVFQ CLCEDQLYPL IGFFGKGYGK
510 520 530 540 550
NKEPVRGYLL AYAIAVAFII IAELNTIAPI ISNFFLCSYA LINFSCFHAS
560 570 580 590 600
ITNSPGWRPS FQYYNKWAAL FGAIISVVIM FLLTWWAALI AIGVVLFLLL
610 620 630 640 650
YVIYKKPEVN WGSSVQAGSY NLALSYSVGL NEVEDHIKNY RPQCLVLTGP
660 670 680 690 700
PNFRPALVDF VGTFTRNLSL MICGHVLIGP HKQRMPELQL IANGHTKWLN
710 720 730 740 750
KRKIKAFYSD VIAEDLRRGV QILMQAAGLG RMKPNILVVG FKKNWQSAHP
760 770 780 790 800
ATVEDYIGIL HDAFDFNYGV CVMRMREGLN VSKMMQAHIN PVFDPAEDGK
810 820 830 840 850
EASARVDPKA LVKEEQATTI FQSEQGKKTI DIYWLFDDGG LTLLIPYLLG
860 870 880 890 900
RKRRWSKCKI RVFVGGQINR MDQERKAIIS LLSKFRLGFH EVHILPDINQ
910 920 930 940 950
NPRAEHTKRF EDMIAPFRLN DGFKDEATVN EMRRDCPWKI SDEEITKNRV
960 970 980 990 1000
KSLRQVRLNE IVLDYSRDAA LIVITLPIGR KGKCPSSLYM AWLETLSQDL
1010 1020
RPPVILIRGN QENVLTFYCQ
Length:1,020
Mass (Da):113,011
Last modified:October 3, 2012 - v1
Checksum:iED2B1A04E21A8856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012181 Genomic DNA. No translation available.
RefSeqiXP_005256176.1. XM_005256119.2.
UniGeneiHs.669115.

Genome annotation databases

EnsembliENST00000262502; ENSP00000262502; ENSG00000070915.
GeneIDi6559.
UCSCiuc059unq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012181 Genomic DNA. No translation available.
RefSeqiXP_005256176.1. XM_005256119.2.
UniGeneiHs.669115.

3D structure databases

ProteinModelPortaliJ3QSS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiJ3QSS1. 1 interaction.
STRINGi9606.ENSP00000402152.

Proteomic databases

PaxDbiJ3QSS1.
PeptideAtlasiJ3QSS1.
PRIDEiJ3QSS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262502; ENSP00000262502; ENSG00000070915.
GeneIDi6559.
UCSCiuc059unq.1. human.

Organism-specific databases

CTDi6559.
HGNCiHGNC:10912. SLC12A3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.

Miscellaneous databases

ChiTaRSiSLC12A3. human.
GenomeRNAii6559.

Gene expression databases

BgeeiENSG00000070915.
ExpressionAtlasiJ3QSS1. baseline and differential.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR018491. SLC12_C.
IPR002948. SLC12A3.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF9. PTHR11827:SF9. 3 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01230. NACLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiJ3QSS1_HUMAN
AccessioniPrimary (citable) accession number: J3QSS1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.