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J3QRF7

- J3QRF7_HUMAN

UniProt

J3QRF7 - J3QRF7_HUMAN

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Protein
Submitted name: Proton-coupled folate transporter
Gene
SLC46A1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. heme transporter activity Source: Ensembl
  2. methotrexate transporter activity Source: Ensembl

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Proton-coupled folate transporterImported
Gene namesi
Name:SLC46A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:30521. SLC46A1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. brush border membrane Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. integral component of membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiJ3QRF7.

Structurei

3D structure databases

ProteinModelPortaliJ3QRF7.

Family & Domainsi

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

J3QRF7-1 [UniParc]FASTAAdd to Basket

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MQEVETLTSH WTLYMNVGGF LVGLFSSTLL GAWSDSVGRR PLLVLASLGL    50
LLQALVSVFV VQLQLHVGYF VLGRILCALL GDFGGLLAAS FASVADVSSS 100
RSRTFRMALL EASIGVAGML ASLLGGHWLR AQGYANPFWL ALALLIAMTL 150
YAAFCFGETL KEPKSTRLFT FRHHRSIVQL YVAPAPEKSR KHLALYSLAI 200
FVVITVHFGA QDILTLYELS TPLCWDSKLI GYGSAAQHLP YLTSLLALKL 250
Length:250
Mass (Da):27,264
Last modified:October 3, 2012 - v1
Checksum:i41E8D638FBF81794
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei250 – 2501Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002094 Genomic DNA. No translation available.
AC015917 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000584995; ENSP00000464190; ENSG00000076351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002094 Genomic DNA. No translation available.
AC015917 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali J3QRF7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000584995 ; ENSP00000464190 ; ENSG00000076351 .

Organism-specific databases

HGNCi HGNC:30521. SLC46A1.
GenAtlasi Search...

Miscellaneous databases

NextBioi 35537036.

Gene expression databases

ArrayExpressi J3QRF7.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiJ3QRF7_HUMAN
AccessioniPrimary (citable) accession number: J3QRF7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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