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Protein
Submitted name:

Proton-coupled folate transporter

Gene

SLC46A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heme transporter activity Source: Ensembl
  2. methotrexate transporter activity Source: Ensembl

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Proton-coupled folate transporterImported
Gene namesi
Name:SLC46A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30521. SLC46A1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. brush border membrane Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. integral component of membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiJ3QRF7. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliJ3QRF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063076.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

J3QRF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEVETLTSH WTLYMNVGGF LVGLFSSTLL GAWSDSVGRR PLLVLASLGL
60 70 80 90 100
LLQALVSVFV VQLQLHVGYF VLGRILCALL GDFGGLLAAS FASVADVSSS
110 120 130 140 150
RSRTFRMALL EASIGVAGML ASLLGGHWLR AQGYANPFWL ALALLIAMTL
160 170 180 190 200
YAAFCFGETL KEPKSTRLFT FRHHRSIVQL YVAPAPEKSR KHLALYSLAI
210 220 230 240 250
FVVITVHFGA QDILTLYELS TPLCWDSKLI GYGSAAQHLP YLTSLLALKL
Length:250
Mass (Da):27,264
Last modified:October 3, 2012 - v1
Checksum:i41E8D638FBF81794
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei250 – 2501Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015917 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000584995; ENSP00000464190; ENSG00000076351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015917 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliJ3QRF7.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiJ3QRF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000584995; ENSP00000464190; ENSG00000076351.

Organism-specific databases

HGNCiHGNC:30521. SLC46A1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063076.

Miscellaneous databases

NextBioi35537036.

Gene expression databases

ExpressionAtlasiJ3QRF7. baseline and differential.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiJ3QRF7_HUMAN
AccessioniPrimary (citable) accession number: J3QRF7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: March 4, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.