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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 3

Gene

MAP3K3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 3Imported
Gene namesi
Name:MAP3K3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6855. MAP3K3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198909.

PTM / Processingi

Proteomic databases

MaxQBiJ3QRB6.
PaxDbiJ3QRB6.
PRIDEiJ3QRB6.

Expressioni

Gene expression databases

BgeeiENSG00000198909.
ExpressionAtlasiJ3QRB6. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiJ3QRB6. 1 interactor.
STRINGi9606.ENSP00000354927.

Structurei

3D structure databases

ProteinModelPortaliJ3QRB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 154PB1InterPro annotationAdd BLAST80
Domaini389 – 649Protein kinaseInterPro annotationAdd BLAST261

Phylogenomic databases

eggNOGiKOG0198. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000270. PB1_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3QRB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQKKHNSSSS
60 70 80 90 100
ALLNSPTVTT SSCAGASEKK KFLSDVRIKF EHNGERRIIA FSRPVKYEDV
110 120 130 140 150
EHKVTTVFGQ PLDLHYMNNE LSILLKNQDD LDKAIDILDR SSSMKSLRIL
160 170 180 190 200
LLSQDRNHNS SSPHSGVSRQ VRIKASQSAG DINTIYQPPE PRSRHLSVSS
210 220 230 240 250
QNPGRSSPPP GYVPERQQHI ARQGSYTSIN SEGEFIPETS EQCMLDPLSS
260 270 280 290 300
AENSLSGSCQ SLDSPSFRKS RMSRAQSFPD NRQEYSDRET QLYDKGVKGG
310 320 330 340 350
TYPRRYHVSV HHKDYSDGRR TFPRIRRHQG NLFTLVPSSR SLSTNGENMG
360 370 380 390 400
LAVQYLDPRG RLRSADSENA LSVQERNVPT KSPSAPINWR RGKLLGQGAF
410 420 430 440 450
GRVYLCYDVD TGRELASKQV QFDPDSPETS KEVSALECEI QLLKNLQHER
460 470 480 490 500
IVQYYGCLRD RAEKTLTIFM EYMPGGSVKD QLKAYGALTE SVTRKYTRQI
510 520 530 540 550
LEGMSYLHSN MIVHRDIKGA NILRDSAGNV KLGDFGASKR LQTICMSGTG
560 570 580 590 600
MRSVTGTPYW MSPEVISGEG YGRKADVWSL GCTVVEMLTE KPPWAEYEAM
610 620 630 640 650
AAIFKIATQP TNPQLPSHIS EHGRDFLRRI FVEARQRPSA EELLTHHFAQ

LMY
Length:653
Mass (Da):73,660
Last modified:October 3, 2012 - v1
Checksum:i1D479294A37F96C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046185 Genomic DNA. No translation available.
RefSeqiXP_005257433.1. XM_005257376.3.
UniGeneiHs.29282.

Genome annotation databases

EnsembliENST00000584573; ENSP00000464130; ENSG00000198909.
GeneIDi4215.
UCSCiuc002jbh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046185 Genomic DNA. No translation available.
RefSeqiXP_005257433.1. XM_005257376.3.
UniGeneiHs.29282.

3D structure databases

ProteinModelPortaliJ3QRB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiJ3QRB6. 1 interactor.
STRINGi9606.ENSP00000354927.

Proteomic databases

MaxQBiJ3QRB6.
PaxDbiJ3QRB6.
PRIDEiJ3QRB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000584573; ENSP00000464130; ENSG00000198909.
GeneIDi4215.
UCSCiuc002jbh.4. human.

Organism-specific databases

CTDi4215.
HGNCiHGNC:6855. MAP3K3.
OpenTargetsiENSG00000198909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0198. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.

Miscellaneous databases

ChiTaRSiMAP3K3. human.
GenomeRNAii4215.

Gene expression databases

BgeeiENSG00000198909.
ExpressionAtlasiJ3QRB6. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000270. PB1_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJ3QRB6_HUMAN
AccessioniPrimary (citable) accession number: J3QRB6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.