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Protein

DNA (cytosine-5)-methyltransferase

Gene

Dnmt1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

DNA-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
Gene namesi
Name:Dnmt1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:94912. Dnmt1.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiJ3QNW0.
PaxDbiJ3QNW0.

Expressioni

Gene expression databases

ExpressionAtlasiJ3QNW0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004202.

Structurei

3D structure databases

ProteinModelPortaliJ3QNW0.
SMRiJ3QNW0. Positions 238-484, 531-1481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini530 – 57647CXXC-typeInterPro annotationAdd
BLAST
Domaini639 – 765127BAHInterPro annotationAdd
BLAST
Domaini857 – 984128BAHInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
GeneTreeiENSGT00390000005100.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3QNW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSNRSPRS RPKPRGPRRS KSDSDTLFET SPSSVATRRT TRQTTITAHF
60 70 80 90 100
TKGPTKRKPK EESEEGNSAE SAAEERDQDK KRRVVDTESG AAAAVEKLEE
110 120 130 140 150
VTAGTQLGPE EPCEQEDDNR SLRRHTRELS LRRKSKEDPD REARPETHLD
160 170 180 190 200
EDEDGKKDKR SSRPRSQPRD PAAKRRPKEA EPEQVAPETP EDRDEDEREE
210 220 230 240 250
KRRKTTRKKL ESHTVPVQSR SERKAAQSKS VIPKINSPKC PECGQHLDDP
260 270 280 290 300
NLKYQQHPED AVDEPQMLTS EKLSIYDSTS TWFDTYEDSP MHRFTSFSVY
310 320 330 340 350
CSRGHLCPVD TGLIEKNVEL YFSGCAKAIH DENPSMEGGI NGKNLGPINQ
360 370 380 390 400
WWLSGFDGGE KVLIGFSTAF AEYILMEPSK EYEPIFGLMQ EKIYISKIVV
410 420 430 440 450
EFLQNNPDAV YEDLINKIET TVPPSTINVN RFTEDSLLRH AQFVVSQVES
460 470 480 490 500
YDEAKDDDET PIFLSPCMRA LIHLAGVSLG QRRATRRVMG ATKEKDKAPT
510 520 530 540 550
KATTTKLVYQ IFDTFFSEQI EKYDKEDKEN AMKRRRCGVC EVCQQPECGK
560 570 580 590 600
CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADDDEEAD DDVSEMPSPK
610 620 630 640 650
KLHQGKKKKQ NKDRISWLGQ PMKIEENRTY YQKVSIDEEM LEVGDCVSVI
660 670 680 690 700
PDDSSKPLYL ARVTALWEDK NGQMMFHAHW FCAGTDTVLG ATSDPLELFL
710 720 730 740 750
VGECENMQLS YIHSKVKVIY KAPSENWAME GGTDPETTLP GAEDGKTYFF
760 770 780 790 800
QLWYNQEYAR FESPPKTQPT EDNKHKFCLS CIRLAELRQK EMPKVLEQIE
810 820 830 840 850
EVDGRVYCSS ITKNGVVYRL GDSVYLPPEA FTFNIKVASP VKRPKKDPVN
860 870 880 890 900
ETLYPEHYRK YSDYIKGSNL DAPEPYRIGR IKEIHCGKKK GKVNEADIKL
910 920 930 940 950
RLYKFYRPEN THRSYNGSYH TDINMLYWSD EEAVVNFSDV QGRCTVEYGE
960 970 980 990 1000
DLLESIQDYS QGGPDRFYFL EAYNSKTKNF EDPPNHARSP GNKGKGKGKG
1010 1020 1030 1040 1050
KGKGKHQVSE PKEPEAAIKL PKLRTLDVFS GCGGLSEGFH QAGISETLWA
1060 1070 1080 1090 1100
IEMWDPAAQA FRLNNPGTTV FTEDCNVLLK LVMAGEVTNS LGQRLPQKGD
1110 1120 1130 1140 1150
VEMLCGGPPC QGFSGMNRFN SRTYSKFKNS LVVSFLSYCD YYRPRFFLLE
1160 1170 1180 1190 1200
NVRNFVSYRR SMVLKLTLRC LVRMGYQCTF GVLQAGQYGV AQTRRRAIIL
1210 1220 1230 1240 1250
AAAPGEKLPL FPEPLHVFAP RACQLSVVVD DKKFVSNITR LSSGPFRTIT
1260 1270 1280 1290 1300
VRDTMSDLPE IQNGASNSEI PYNGEPLSWF QRQLRGSHYQ PILRDHICKD
1310 1320 1330 1340 1350
MSPLVAARMR HIPLFPGSDW RDLPNIQVRL GDGVIAHKLQ YTFHDVKNGY
1360 1370 1380 1390 1400
SSTGALRGVC SCAEGKACDP ESRQFSTLIP WCLPHTGNRH NHWAGLYGRL
1410 1420 1430 1440 1450
EWDGFFSTTV TNPEPMGKQG RVLHPEQHRV VSVRECARSQ GFPDSYRFFG
1460 1470 1480 1490 1500
NILDRHRQVG NAVPPPLAKA IGLEIKLCLL SSARESASAA VKAKEEAATK

D
Length:1,501
Mass (Da):169,957
Last modified:October 3, 2012 - v1
Checksum:i3325C8F8EC45A767
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC170598 Genomic DNA. No translation available.
RefSeqiNP_001186361.1. NM_001199432.1.
UniGeneiMm.128580.
Mm.485562.

Genome annotation databases

EnsembliENSMUST00000177754; ENSMUSP00000136982; ENSMUSG00000004099.
GeneIDi13433.
UCSCiuc009ojs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC170598 Genomic DNA. No translation available.
RefSeqiNP_001186361.1. NM_001199432.1.
UniGeneiMm.128580.
Mm.485562.

3D structure databases

ProteinModelPortaliJ3QNW0.
SMRiJ3QNW0. Positions 238-484, 531-1481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004202.

Proteomic databases

MaxQBiJ3QNW0.
PaxDbiJ3QNW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000177754; ENSMUSP00000136982; ENSMUSG00000004099.
GeneIDi13433.
UCSCiuc009ojs.2. mouse.

Organism-specific databases

CTDi1786.
MGIiMGI:94912. Dnmt1.

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
GeneTreeiENSGT00390000005100.

Miscellaneous databases

ChiTaRSiDnmt1. mouse.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiJ3QNW0. baseline and differential.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJ3QNW0_MOUSE
AccessioniPrimary (citable) accession number: J3QNW0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.