ID   J3QLI0_HUMAN            Unreviewed;       200 AA.
AC   J3QLI0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Apolipoprotein H {ECO:0000313|Ensembl:ENSP00000463553.1};
DE   Flags: Fragment;
GN   Name=APOH {ECO:0000313|Ensembl:ENSP00000463553.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463553.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463553.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000463553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AC006120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; J3QLI0; -.
DR   SMR; J3QLI0; -.
DR   MassIVE; J3QLI0; -.
DR   PeptideAtlas; J3QLI0; -.
DR   Antibodypedia; 874; 608 antibodies from 40 providers.
DR   Ensembl; ENST00000581797.5; ENSP00000463553.1; ENSG00000091583.11.
DR   UCSC; uc060izv.1; human.
DR   HGNC; HGNC:616; APOH.
DR   VEuPathDB; HostDB:ENSG00000091583; -.
DR   GeneTree; ENSGT00940000157228; -.
DR   HOGENOM; CLU_020107_2_1_1; -.
DR   OMA; IAGRRMW; -.
DR   ChiTaRS; APOH; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000091583; Expressed in liver and 126 other cell types or tissues.
DR   ExpressionAtlas; J3QLI0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd00033; CCP; 3.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   PANTHER; PTHR19325:SF549; BETA-2-GLYCOPROTEIN 1; 1.
DR   PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR   Pfam; PF00084; Sushi; 3.
DR   SMART; SM00032; CCP; 3.
DR   SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR   PROSITE; PS50923; SUSHI; 3.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00302};
KW   Proteomics identification {ECO:0007829|MaxQB:J3QLI0,
KW   ECO:0007829|PeptideAtlas:J3QLI0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW   ProRule:PRU00302}.
FT   DOMAIN          22..79
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          80..142
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          143..200
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DISULFID        50..77
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT   DISULFID        145..188
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT   NON_TER         200
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000463553.1"
SQ   SEQUENCE   200 AA;  22176 MW;  BC95856D80BFECFB CRC64;
     MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF EYPNTISFSC NTGFYLNGAD
     SAKCTEEGKW SPELPVCAPI ICPPPSIPTF ATLRVYKPSA GNNSLYRDTA VFECLPQHAM
     FGNDTITCTT HGNWTKLPEC REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL
     DGPEEIECTK LGNWSAMPSC
//