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Protein
Submitted name:

Septin-4

Gene

SEPT4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei164Important for dimerizationUniRule annotation1

GO - Molecular functioni

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Septin-4Imported
Gene namesi
Name:SEPT4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108387.14.
HGNCiHGNC:9165. SEPT4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108387.

PTM / Processingi

Proteomic databases

PaxDbiJ3KSZ7.
PeptideAtlasiJ3KSZ7.
PRIDEiJ3KSZ7.

Expressioni

Gene expression databases

BgeeiENSG00000108387.
ExpressionAtlasiJ3KSZ7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliJ3KSZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 315Septin-type GInterPro annotationAdd BLAST274

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili354 – 377Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00880000137871.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
InterProiView protein in InterPro
IPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR030643. Septin4.
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF102. PTHR18884:SF102. 1 hit.
PfamiView protein in Pfam
PF00735. Septin. 1 hit.
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51719. G_SEPTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

J3KSZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSLGWQGN SVPEDRTEAG DDKEYVGFAT LPNQVHRKSV KKGFDFTLMV
60 70 80 90 100
AGESGLGKST LVNSLFLTDL YRDRKLLGAE ERIMQTVEIT KHAVDIEEKG
110 120 130 140 150
VRLRLTIVDT PGFGDAVNNT ECWKPVAEYI DQQFEQYFRD ESGLNRKNIQ
160 170 180 190 200
DNRVHCCLYF ISPFGHGLRP LDVEFMKALH QRVNIVPILA KADTLTPPEV
210 220 230 240 250
DHKKRKIREE IEHFGIKIYQ FPDCDSDEDE DFKLQDQALK ESIPFAVIGS
260 270 280 290 300
NTVVEARGRR VRGRLYPWGI VEVENPGHCD FVKLRTMLVR THMQDLKDVT
310 320 330 340 350
RETHYENYRA QCIQSMTRLV VKERNRNKLT RESGTDFPIP AVPPGTDPET
360 370
EKLIREKDEE LRRMQEMLHK IQKQMKENY
Length:379
Mass (Da):43,952
Last modified:October 3, 2012 - v1
Checksum:i13E57B35DC0D75FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005666 Genomic DNA. No translation available.
RefSeqiXP_006722014.1. XM_006721951.2.
UniGeneiHs.287518.

Genome annotation databases

EnsembliENST00000580844; ENSP00000462727; ENSG00000108387.
GeneIDi5414.
UCSCiuc060hyz.1. human.

Similar proteinsi

Entry informationi

Entry nameiJ3KSZ7_HUMAN
AccessioniPrimary (citable) accession number: J3KSZ7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 27, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported