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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 3

Gene

MAP3K3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 3Imported
Gene namesi
Name:MAP3K3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198909.7
HGNCiHGNC:6855 MAP3K3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198909

PTM / Processingi

Proteomic databases

MaxQBiJ3KRN4
PeptideAtlasiJ3KRN4
PRIDEiJ3KRN4

Expressioni

Gene expression databases

BgeeiENSG00000198909
ExpressionAtlasiJ3KRN4 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiJ3KRN4, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliJ3KRN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 123PB1InterPro annotationAdd BLAST80
Domaini358 – 618Protein kinaseInterPro annotationAdd BLAST261

Phylogenomic databases

GeneTreeiENSGT00800000124036

Family and domain databases

CDDicd06405 PB1_Mekk2_3, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000270 PB1_dom
IPR034879 PB1_MEKK2/3
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

J3KRN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE
60 70 80 90 100
HNGERRIIAF SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL
110 120 130 140 150
DKAIDILDRS SSMKSLRILL LSQDRNHNSS SPHSGVSRQV RIKASQSAGD
160 170 180 190 200
INTIYQPPEP RSRHLSVSSQ NPGRSSPPPG YVPERQQHIA RQGSYTSINS
210 220 230 240 250
EGEFIPETSE QCMLDPLSSA ENSLSGSCQS LDSPSFRKSR MSRAQSFPDN
260 270 280 290 300
RQEYSDRETQ LYDKGVKGGT YPRRYHVSVH HKDYSDGRRT FPRIRRHQGN
310 320 330 340 350
LFTLVPSSRS LSTNGENMGL AVQYLDPRGR LRSADSENAL SVQERNVPTK
360 370 380 390 400
SPSAPINWRR GKLLGQGAFG RVYLCYDVDT GRELASKQVQ FDPDSPETSK
410 420 430 440 450
EVSALECEIQ LLKNLQHERI VQYYGCLRDR AEKTLTIFME YMPGGSVKDQ
460 470 480 490 500
LKAYGALTES VTRKYTRQIL EGMSYLHSNM IVHRDIKGAN ILRDSAGNVK
510 520 530 540 550
LGDFGASKRL QTICMSGTGM RSVTGTPYWM SPEVISGEGY GRKADVWSLG
560 570 580 590 600
CTVVEMLTEK PPWAEYEAMA AIFKIATQPT NPQLPSHISE HGRDFLRRIF
610 620
VEARQRPSAE ELLTHHFAQL MY
Length:622
Mass (Da):70,468
Last modified:October 3, 2012 - v1
Checksum:iB0CC703710CFC461
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046185 Genomic DNA No translation available.
RefSeqiNP_001317360.1, NM_001330431.1
UniGeneiHs.29282

Genome annotation databases

EnsembliENST00000577395; ENSP00000462086; ENSG00000198909
GeneIDi4215
UCSCiuc010wpp.3 human

Similar proteinsi

Entry informationi

Entry nameiJ3KRN4_HUMAN
AccessioniPrimary (citable) accession number: J3KRN4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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