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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 3

Gene

MAP3K3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 3Imported
Gene namesi
Name:MAP3K3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198909.7.
HGNCiHGNC:6855. MAP3K3.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198909.

PTM / Processingi

Proteomic databases

MaxQBiJ3KRN4.
PeptideAtlasiJ3KRN4.
PRIDEiJ3KRN4.

Expressioni

Gene expression databases

BgeeiENSG00000198909.
ExpressionAtlasiJ3KRN4. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiJ3KRN4. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliJ3KRN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 123PB1InterPro annotationAdd BLAST80
Domaini358 – 618Protein kinaseInterPro annotationAdd BLAST261

Phylogenomic databases

GeneTreeiENSGT00800000124036.

Family and domain databases

CDDicd06405. PB1_Mekk2_3. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR034881. MAPKKK3.
IPR000270. PB1_dom.
IPR034879. PB1_MEKK2/3.
IPR000719. Prot_kinase_dom.
PANTHERiPTHR24361:SF482. PTHR24361:SF482. 1 hit.
PfamiView protein in Pfam
PF00564. PB1. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00666. PB1. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51745. PB1. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

J3KRN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE
60 70 80 90 100
HNGERRIIAF SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL
110 120 130 140 150
DKAIDILDRS SSMKSLRILL LSQDRNHNSS SPHSGVSRQV RIKASQSAGD
160 170 180 190 200
INTIYQPPEP RSRHLSVSSQ NPGRSSPPPG YVPERQQHIA RQGSYTSINS
210 220 230 240 250
EGEFIPETSE QCMLDPLSSA ENSLSGSCQS LDSPSFRKSR MSRAQSFPDN
260 270 280 290 300
RQEYSDRETQ LYDKGVKGGT YPRRYHVSVH HKDYSDGRRT FPRIRRHQGN
310 320 330 340 350
LFTLVPSSRS LSTNGENMGL AVQYLDPRGR LRSADSENAL SVQERNVPTK
360 370 380 390 400
SPSAPINWRR GKLLGQGAFG RVYLCYDVDT GRELASKQVQ FDPDSPETSK
410 420 430 440 450
EVSALECEIQ LLKNLQHERI VQYYGCLRDR AEKTLTIFME YMPGGSVKDQ
460 470 480 490 500
LKAYGALTES VTRKYTRQIL EGMSYLHSNM IVHRDIKGAN ILRDSAGNVK
510 520 530 540 550
LGDFGASKRL QTICMSGTGM RSVTGTPYWM SPEVISGEGY GRKADVWSLG
560 570 580 590 600
CTVVEMLTEK PPWAEYEAMA AIFKIATQPT NPQLPSHISE HGRDFLRRIF
610 620
VEARQRPSAE ELLTHHFAQL MY
Length:622
Mass (Da):70,468
Last modified:October 3, 2012 - v1
Checksum:iB0CC703710CFC461
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046185 Genomic DNA. No translation available.
RefSeqiNP_001317360.1. NM_001330431.1.
UniGeneiHs.29282.

Genome annotation databases

EnsembliENST00000577395; ENSP00000462086; ENSG00000198909.
GeneIDi4215.
UCSCiuc010wpp.3. human.

Similar proteinsi

Entry informationi

Entry nameiJ3KRN4_HUMAN
AccessioniPrimary (citable) accession number: J3KRN4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 27, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported