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Protein
Submitted name:

Tribbles homolog 3

Gene

TRIB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tribbles homolog 3Imported
Gene namesi
Name:TRIB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16228. TRIB3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiJ3KR25.

Expressioni

Gene expression databases

ExpressionAtlasiJ3KR25. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000217233.

Structurei

3D structure databases

ProteinModelPortaliJ3KR25.
SMRiJ3KR25. Positions 99-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 342248Protein kinaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
OMAiYTCKVYP.
PhylomeDBiJ3KR25.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
IPR024106. Tribbles_TRB3.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF14. PTHR22961:SF14. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3KR25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMHLAVKN NRMSANNDHF LTPTWQQMRA TPLAAPAGSL SRKKRLELDD
60 70 80 90 100
NLDTERPVQK RARSGPQPRL PPCLLPLSPP TAPDRATAVA TASRLGPYVL
110 120 130 140 150
LEPEEGGRAY QALHCPTGTE YTCKVYPVQE ALAVLEPYAR LPPHKHVARP
160 170 180 190 200
TEVLAGTQLL YAFFTRTHGD MHSLVRSRHR IPEPEAAVLF RQMATALAHC
210 220 230 240 250
HQHGLVLRDL KLCRFVFADR ERKKLVLENL EDSCVLTGPD DSLWDKHACP
260 270 280 290 300
AYVGPEILSS RASYSGKAAD VWSLGVALFT MLAGHYPFQD SEPVLLFGKI
310 320 330 340 350
RRGAYALPAG LSAPARCLVR CLLRREPAER LTATGILLHP WLRQDPMPLA
360 370 380
PTRSHLWEAA QVVPDGLGLD EAREEEGDRE VVLYG
Length:385
Mass (Da):42,757
Last modified:October 3, 2012 - v1
Checksum:i46A0C1B6EB5E814C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034548 Genomic DNA. No translation available.
KF456775 Genomic DNA. No translation available.
RefSeqiNP_001288130.1. NM_001301201.1.
UniGeneiHs.516826.

Genome annotation databases

EnsembliENST00000422053; ENSP00000415416; ENSG00000101255.
GeneIDi57761.
UCSCiuc002wdn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034548 Genomic DNA. No translation available.
KF456775 Genomic DNA. No translation available.
RefSeqiNP_001288130.1. NM_001301201.1.
UniGeneiHs.516826.

3D structure databases

ProteinModelPortaliJ3KR25.
SMRiJ3KR25. Positions 99-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000217233.

Proteomic databases

PaxDbiJ3KR25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422053; ENSP00000415416; ENSG00000101255.
GeneIDi57761.
UCSCiuc002wdn.4. human.

Organism-specific databases

CTDi57761.
HGNCiHGNC:16228. TRIB3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
OMAiYTCKVYP.
PhylomeDBiJ3KR25.

Miscellaneous databases

ChiTaRSiTRIB3. human.
GenomeRNAii57761.

Gene expression databases

ExpressionAtlasiJ3KR25. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
IPR024106. Tribbles_TRB3.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF14. PTHR22961:SF14. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJ3KR25_HUMAN
AccessioniPrimary (citable) accession number: J3KR25
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.