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Protein
Submitted name:

Ephrin type-B receptor 6

Gene

EPHB6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ephrin type-B receptor 6Imported
Gene namesi
Name:EPHB6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:3396. EPHB6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei303 – 32725HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiJ3KQU5.

Expressioni

Gene expression databases

ExpressionAtlasiJ3KQU5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376684.

Structurei

3D structure databases

ProteinModelPortaliJ3KQU5.
SMRiJ3KQU5. Positions 1-295, 370-634, 664-715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 194118Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini195 – 29096Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini378 – 627250Protein kinaseInterPro annotationAdd
BLAST
Domaini664 – 72057SAM (sterile alpha motif)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains SAM (sterile alpha motif) domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
KOiK05114.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR003961. FN3_dom.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3KQU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVGGCRCQ PGYQPARGDK ACQACPRGLY KASAGNAPCS PCPARSHAPN
60 70 80 90 100
PAAPVCPCLE GFYRASSDPP EAPCTGPPSA PQELWFEVQG SALMLHWRLP
110 120 130 140 150
RELGGRGDLL FNVVCKECEG RQEPASGGGG TCHRCRDEVH FDPRQRGLTE
160 170 180 190 200
SRVLVGGLRA HVPYILEVQA VNGVSELSPD PPQAAAINVS TSHEVPSAVP
210 220 230 240 250
VVHQVSRASN SITVSWPQPD QTNGNILDYQ LRYYDQAEDE SHSFTLTSET
260 270 280 290 300
NTATVTQLSP GHIYGFQVRA RTAAGHGPYG GKVYFQTLPQ GELSSQLPER
310 320 330 340 350
LSLVIGSILG ALAFLLLAAI TVLAVVFQRK RRGTGYTEQL QQYSSPGLGV
360 370 380 390 400
KYYIDPSTYE DPCQAIRELA REVDPAYIKI EEVIGTGSFG EVRQGRLQPR
410 420 430 440 450
GRREQTVAIQ ALWAGGAESL QMTFLGRAAV LGQFQHPNIL RLEGVVTKSR
460 470 480 490 500
PLMVLTEFME LGPLDSFLRQ REGQFSSLQL VAMQRGVAAA MQYLSSFAFV
510 520 530 540 550
HRSLSAHSVL VNSHLVCKVA RLGHSPQGPS CLLRWAAPEV IAHGKHTTSS
560 570 580 590 600
DVWSFGILMW EVMSYGERPY WDMSEQEVLN AIEQEFRLPP PPGCPPGLHL
610 620 630 640 650
LMLDTWQKDR ARRPHFDQLV AAFDKMIRKP DTLQAGGDPG ERPSQALLTP
660 670 680 690 700
VALDFPCLDS PQAWLSAIGL ECYQDNFSKF GLCTFSDVAQ LSLEDLPALG
710 720
ITLAGHQKKL LHHIQLLQQH LRQQGSVEV
Length:729
Mass (Da):79,768
Last modified:October 29, 2014 - v2
Checksum:i9A6BD391485CDDA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245427 Genomic DNA. No translation available.
RefSeqiNP_001267723.2. NM_001280794.2.
NP_001267724.2. NM_001280795.2.
UniGeneiHs.380089.

Genome annotation databases

EnsembliENST00000411471; ENSP00000409061; ENSG00000106123.
GeneIDi2051.
KEGGihsa:2051.
UCSCiuc033anu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245427 Genomic DNA. No translation available.
RefSeqiNP_001267723.2. NM_001280794.2.
NP_001267724.2. NM_001280795.2.
UniGeneiHs.380089.

3D structure databases

ProteinModelPortaliJ3KQU5.
SMRiJ3KQU5. Positions 1-295, 370-634, 664-715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376684.

Proteomic databases

PaxDbiJ3KQU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411471; ENSP00000409061; ENSG00000106123.
GeneIDi2051.
KEGGihsa:2051.
UCSCiuc033anu.2. human.

Organism-specific databases

CTDi2051.
HGNCiHGNC:3396. EPHB6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
KOiK05114.

Miscellaneous databases

ChiTaRSiEPHB6. human.
GenomeRNAii2051.

Gene expression databases

ExpressionAtlasiJ3KQU5. baseline and differential.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR003961. FN3_dom.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiJ3KQU5_HUMAN
AccessioniPrimary (citable) accession number: J3KQU5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 29, 2014
Last modified: June 8, 2016
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.