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Protein
Submitted name:

HLA class II histocompatibility antigen, DP alpha 1 chain

Gene

HLA-DPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class II histocompatibility antigen, DP alpha 1 chainImported
Gene namesi
Name:HLA-DPA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000231389.7.
HGNCiHGNC:4938. HLA-DPA1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_500377206932 – 209Sequence analysisAdd BLAST178

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiJ3KQ99.
PRIDEiJ3KQ99.

Expressioni

Gene expression databases

BgeeiENSG00000231389.
ExpressionAtlasiJ3KQ99. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliJ3KQ99.
SMRiJ3KQ99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 198Ig-likeInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
GeneTreeiENSGT00900000140882.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Fragment.

J3KQ99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT
60 70 80 90 100
GEFMFEFDED EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN
110 120 130 140 150
LNTLIQRSNH TQATNDPPEV TVFPKEPVEL GQPNTLICHI DKFFPPVLNV
160 170 180 190 200
TWLCNGELVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED FYDCRVEHWG

LDQPLLKHW
Length:209
Mass (Da):24,059
Last modified:October 3, 2012 - v1
Checksum:iA35BD875D247BB3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei209Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645931 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000453337; ENSP00000390929; ENSG00000231389.
UCSCiuc063ntw.1. human.

Similar proteinsi

Entry informationi

Entry nameiJ3KQ99_HUMAN
AccessioniPrimary (citable) accession number: J3KQ99
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported