UniProtKB - J3KPF9 (J3KPF9_HUMAN)
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Protein
Kinesin-like protein
Gene
KIF3A
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 100 – 107 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- microtubule binding Source: InterPro
- microtubule motor activity Source: InterPro
GO - Biological processi
- microtubule-based movement Source: InterPro
Keywordsi
Molecular function | Motor proteinPROSITE-ProRule annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like proteinUniRule annotation |
Gene namesi | Name:KIF3AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131437.15. |
HGNCi | HGNC:6319. KIF3A. |
Expressioni
Gene expression databases
Bgeei | ENSG00000131437. |
ExpressionAtlasi | J3KPF9. baseline and differential. |
Interactioni
GO - Molecular functioni
- microtubule binding Source: InterPro
Protein-protein interaction databases
IntActi | J3KPF9. 7 interactors. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 345 | Kinesin motorInterPro annotationAdd BLAST | 332 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 356 – 380 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 426 – 481 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 490 – 541 | Sequence analysisAdd BLAST | 52 | |
Coiled coili | 556 – 587 | Sequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG4280. Eukaryota. COG5059. LUCA. |
GeneTreei | ENSGT00910000143992. |
Family and domain databases
Gene3Di | 3.40.850.10. 1 hit. |
InterProi | View protein in InterPro IPR027640. Kinesin-like_fam. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR036961. Kinesin_motor_dom_sf. IPR027417. P-loop_NTPase. |
PANTHERi | PTHR24115. PTHR24115. 2 hits. |
Pfami | View protein in Pfam PF00225. Kinesin. 1 hit. |
PRINTSi | PR00380. KINESINHEAVY. |
SMARTi | View protein in SMART SM00129. KISc. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS00411. KINESIN_MOTOR_1. 1 hit. PS50067. KINESIN_MOTOR_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
J3KPF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK
60 70 80 90 100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG
110 120 130 140 150
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL
160 170 180 190 200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT
210 220 230 240 250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD
260 270 280 290 300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
310 320 330 340 350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR
360 370 380 390 400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE
410 420 430 440 450
DGEKRKKRRD QAGKKKVSPD KMIEMQAKID EERKALETKL DMEEEERNKA
460 470 480 490 500
RAELEKREKD LLKAQQEHQS LLEKLSALEK KVIVGGVDLL AKAEEQEKLL
510 520 530 540 550
EESNMELEER RKRAEQLRRE LEEKEQERLD IEEKYTSLQE EAQGKTKKLK
560 570 580 590 600
KVWTMLMAAK SEMADLQQEH QREIEGLLEN IRQLSRELRL QMLIIDNFIP
610 620 630 640 650
RDYQEMIENY VHWNEDIGEW QLKCVAYTGN NMRKQTPVPD KKEKDPFEVD
660 670 680 690 700
LSHVYLAYTE ESLRQSLMKL ERPRTSKGKA RPKTGRRKRS AKPETVIDSL
LQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004039 Genomic DNA. No translation available. AC004237 Genomic DNA. No translation available. |
RefSeqi | NP_001287721.1. NM_001300792.1. |
UniGenei | Hs.43670. |
Genome annotation databases
Ensembli | ENST00000378735; ENSP00000368009; ENSG00000131437. |
GeneIDi | 11127. |
UCSCi | uc003kxp.4. human. |
Similar proteinsi
Entry informationi
Entry namei | J3KPF9_HUMAN | |
Accessioni | J3KPF9Primary (citable) accession number: J3KPF9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | March 28, 2018 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |