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Protein

Kinesin-like protein

Gene

KIF3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like proteinUniRule annotation
Gene namesi
Name:KIF3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000131437.15
HGNCiHGNC:6319 KIF3A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131437

PTM / Processingi

Proteomic databases

MaxQBiJ3KPF9
PRIDEiJ3KPF9

Expressioni

Gene expression databases

BgeeiENSG00000131437
ExpressionAtlasiJ3KPF9 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiJ3KPF9, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliJ3KPF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 345Kinesin motorInterPro annotationAdd BLAST332

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili356 – 380Sequence analysisAdd BLAST25
Coiled coili426 – 481Sequence analysisAdd BLAST56
Coiled coili490 – 541Sequence analysisAdd BLAST52
Coiled coili556 – 587Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

J3KPF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK
60 70 80 90 100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG
110 120 130 140 150
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL
160 170 180 190 200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT
210 220 230 240 250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD
260 270 280 290 300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
310 320 330 340 350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR
360 370 380 390 400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE
410 420 430 440 450
DGEKRKKRRD QAGKKKVSPD KMIEMQAKID EERKALETKL DMEEEERNKA
460 470 480 490 500
RAELEKREKD LLKAQQEHQS LLEKLSALEK KVIVGGVDLL AKAEEQEKLL
510 520 530 540 550
EESNMELEER RKRAEQLRRE LEEKEQERLD IEEKYTSLQE EAQGKTKKLK
560 570 580 590 600
KVWTMLMAAK SEMADLQQEH QREIEGLLEN IRQLSRELRL QMLIIDNFIP
610 620 630 640 650
RDYQEMIENY VHWNEDIGEW QLKCVAYTGN NMRKQTPVPD KKEKDPFEVD
660 670 680 690 700
LSHVYLAYTE ESLRQSLMKL ERPRTSKGKA RPKTGRRKRS AKPETVIDSL

LQ
Length:702
Mass (Da):80,355
Last modified:October 3, 2012 - v1
Checksum:i28EEEA27FBF1F2A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004039 Genomic DNA No translation available.
AC004237 Genomic DNA No translation available.
RefSeqiNP_001287721.1, NM_001300792.1
UniGeneiHs.43670

Genome annotation databases

EnsembliENST00000378735; ENSP00000368009; ENSG00000131437
GeneIDi11127
UCSCiuc003kxp.4 human

Similar proteinsi

Entry informationi

Entry nameiJ3KPF9_HUMAN
AccessioniPrimary (citable) accession number: J3KPF9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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