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Protein

Kinesin-like protein

Gene

KIF3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor proteinUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like proteinUniRule annotation
Gene namesi
Name:KIF3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6319. KIF3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MicrotubuleUniRule annotation

PTM / Processingi

Proteomic databases

EPDiJ3KPF9.
PaxDbiJ3KPF9.
PRIDEiJ3KPF9.

PTM databases

iPTMnetiJ3KPF9.

Expressioni

Gene expression databases

ExpressionAtlasiJ3KPF9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368020.

Structurei

3D structure databases

ProteinModelPortaliJ3KPF9.
SMRiJ3KPF9. Positions 13-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 345332Kinesin motorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili356 – 38025Sequence analysisAdd
BLAST
Coiled coili426 – 48156Sequence analysisAdd
BLAST
Coiled coili490 – 54152Sequence analysisAdd
BLAST
Coiled coili556 – 58732Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.UniRule annotationSAAS annotation
Contains 1 kinesin motor domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3KPF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK
60 70 80 90 100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG
110 120 130 140 150
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL
160 170 180 190 200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT
210 220 230 240 250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD
260 270 280 290 300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
310 320 330 340 350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR
360 370 380 390 400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE
410 420 430 440 450
DGEKRKKRRD QAGKKKVSPD KMIEMQAKID EERKALETKL DMEEEERNKA
460 470 480 490 500
RAELEKREKD LLKAQQEHQS LLEKLSALEK KVIVGGVDLL AKAEEQEKLL
510 520 530 540 550
EESNMELEER RKRAEQLRRE LEEKEQERLD IEEKYTSLQE EAQGKTKKLK
560 570 580 590 600
KVWTMLMAAK SEMADLQQEH QREIEGLLEN IRQLSRELRL QMLIIDNFIP
610 620 630 640 650
RDYQEMIENY VHWNEDIGEW QLKCVAYTGN NMRKQTPVPD KKEKDPFEVD
660 670 680 690 700
LSHVYLAYTE ESLRQSLMKL ERPRTSKGKA RPKTGRRKRS AKPETVIDSL

LQ
Length:702
Mass (Da):80,355
Last modified:October 3, 2012 - v1
Checksum:i28EEEA27FBF1F2A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. No translation available.
RefSeqiNP_001287721.1. NM_001300792.1.
UniGeneiHs.43670.

Genome annotation databases

EnsembliENST00000378735; ENSP00000368009; ENSG00000131437.
GeneIDi11127.
UCSCiuc003kxp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. No translation available.
RefSeqiNP_001287721.1. NM_001300792.1.
UniGeneiHs.43670.

3D structure databases

ProteinModelPortaliJ3KPF9.
SMRiJ3KPF9. Positions 13-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368020.

PTM databases

iPTMnetiJ3KPF9.

Proteomic databases

EPDiJ3KPF9.
PaxDbiJ3KPF9.
PRIDEiJ3KPF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378735; ENSP00000368009; ENSG00000131437.
GeneIDi11127.
UCSCiuc003kxp.4. human.

Organism-specific databases

CTDi11127.
HGNCiHGNC:6319. KIF3A.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.

Miscellaneous databases

ChiTaRSiKIF3A. human.
GenomeRNAii11127.
NextBioi35535115.

Gene expression databases

ExpressionAtlasiJ3KPF9. baseline and differential.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiJ3KPF9_HUMAN
AccessioniPrimary (citable) accession number: J3KPF9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: May 11, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.