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UniProtKB - J3KPF9 (J3KPF9_HUMAN)

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Protein

Kinesin-like protein

Gene

KIF3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like proteinUniRule annotation
Gene namesi
Name:KIF3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6319. KIF3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MicrotubuleUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131437.

PTM / Processingi

Proteomic databases

MaxQBiJ3KPF9.
PaxDbiJ3KPF9.
PeptideAtlasiJ3KPF9.
PRIDEiJ3KPF9.

Expressioni

Gene expression databases

BgeeiENSG00000131437.
ExpressionAtlasiJ3KPF9. baseline and differential.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

IntActiJ3KPF9. 7 interactors.
STRINGi9606.ENSP00000368020.

Structurei

3D structure databases

ProteinModelPortaliJ3KPF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 345Kinesin motorInterPro annotationAdd BLAST332

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili356 – 380Sequence analysisAdd BLAST25
Coiled coili426 – 481Sequence analysisAdd BLAST56
Coiled coili490 – 541Sequence analysisAdd BLAST52
Coiled coili556 – 587Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00880000137847.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

J3KPF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK 
        60         70         80         90        100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG 
       110        120        130        140        150
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL 
       160        170        180        190        200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT 
       210        220        230        240        250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD 
       260        270        280        290        300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS 
       310        320        330        340        350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR 
       360        370        380        390        400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE 
       410        420        430        440        450
DGEKRKKRRD QAGKKKVSPD KMIEMQAKID EERKALETKL DMEEEERNKA 
       460        470        480        490        500
RAELEKREKD LLKAQQEHQS LLEKLSALEK KVIVGGVDLL AKAEEQEKLL 
       510        520        530        540        550
EESNMELEER RKRAEQLRRE LEEKEQERLD IEEKYTSLQE EAQGKTKKLK 
       560        570        580        590        600
KVWTMLMAAK SEMADLQQEH QREIEGLLEN IRQLSRELRL QMLIIDNFIP 
       610        620        630        640        650
RDYQEMIENY VHWNEDIGEW QLKCVAYTGN NMRKQTPVPD KKEKDPFEVD 
       660        670        680        690        700
LSHVYLAYTE ESLRQSLMKL ERPRTSKGKA RPKTGRRKRS AKPETVIDSL 

LQ
Length:702
Mass (Da):80,355
Last modified:October 3, 2012 - v1
Checksum:i28EEEA27FBF1F2A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. No translation available.
RefSeqiNP_001287721.1. NM_001300792.1.
UniGeneiHs.43670.

Genome annotation databases

EnsembliENST00000378735; ENSP00000368009; ENSG00000131437.
GeneIDi11127.
UCSCiuc003kxp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. No translation available.
RefSeqiNP_001287721.1. NM_001300792.1.
UniGeneiHs.43670.

3D structure databases

ProteinModelPortaliJ3KPF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiJ3KPF9. 7 interactors.
STRINGi9606.ENSP00000368020.

Proteomic databases

MaxQBiJ3KPF9.
PaxDbiJ3KPF9.
PeptideAtlasiJ3KPF9.
PRIDEiJ3KPF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378735; ENSP00000368009; ENSG00000131437.
GeneIDi11127.
UCSCiuc003kxp.4. human.

Organism-specific databases

CTDi11127.
HGNCiHGNC:6319. KIF3A.
OpenTargetsiENSG00000131437.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00880000137847.

Miscellaneous databases

ChiTaRSiKIF3A. human.
GenomeRNAii11127.

Gene expression databases

BgeeiENSG00000131437.
ExpressionAtlasiJ3KPF9. baseline and differential.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiJ3KPF9_HUMAN
AccessioniPrimary (citable) accession number: J3KPF9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 7, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.