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Protein
Submitted name:

Semaphorin-4B

Gene

SEMA4B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Semaphorin-4BImported
Gene namesi
Name:SEMA4BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000185033.14
HGNCiHGNC:10730 SEMA4B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei718 – 738HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185033

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_501409858644 – 837Sequence analysisAdd BLAST794

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiJ3KNP4
PeptideAtlasiJ3KNP4
PRIDEiJ3KNP4

Expressioni

Gene expression databases

BgeeiENSG00000185033
ExpressionAtlasiJ3KNP4 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 523SemaInterPro annotationAdd BLAST477

Sequence similaritiesi

Belongs to the semaphorin family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
KOiK06521
OMAiCPFDPNF
OrthoDBiEOG091G01W0
TreeFamiTF352903

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

J3KNP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTAMGLRS WLAAPWGALP PRPPLLLLLL LLLLLQPPPP TWALSPRISL
60 70 80 90 100
PLGSEERPFL RFEAEHISNY TALLLSRDGR TLYVGAREAL FALSSNLSFL
110 120 130 140 150
PGGEYQELLW GADAEKKQQC SFKGKDPQRD CQNYIKILLP LSGSHLFTCG
160 170 180 190 200
TAAFSPMCTY INMENFTLAR DEKGNVLLED GKGRCPFDPN FKSTALVVDG
210 220 230 240 250
ELYTGTVSSF QGNDPAISRS QSLRPTKTES SLNWLQDPAF VASAYIPESL
260 270 280 290 300
GSLQGDDDKI YFFFSETGQE FEFFENTIVS RIARICKGDE GGERVLQQRW
310 320 330 340 350
TSFLKAQLLC SRPDDGFPFN VLQDVFTLSP SPQDWRDTLF YGVFTSQWHR
360 370 380 390 400
GTTEGSAVCV FTMKDVQRVF SGLYKEVNRE TQQWYTVTHP VPTPRPGACI
410 420 430 440 450
TNSARERKIN SSLQLPDRVL NFLKDHFLMD GQVRSRMLLL QPQARYQRVA
460 470 480 490 500
VHRVPGLHHT YDVLFLGTGD GRLHKAVSVG PRVHIIEELQ IFSSGQPVQN
510 520 530 540 550
LLLDTHRGLL YAASHSGVVQ VPMANCSLYR SCGDCLLARD PYCAWSGSSC
560 570 580 590 600
KHVSLYQPQL ATRPWIQDIE GASAKDLCSA SSVVSPSFVP TGEKPCEQVQ
610 620 630 640 650
FQPNTVNTLA CPLLSNLATR LWLRNGAPVN ASASCHVLPT GDLLLVGTQQ
660 670 680 690 700
LGEFQCWSLE EGFQQLVASY CPEVVEDGVA DQTDEGGSVP VIISTSRVSA
710 720 730 740 750
PAGGKASWGA DRSYWKEFLV MCTLFVLAVL LPVLFLLYRH RNSMKVFLKQ
760 770 780 790 800
GECASVHPKT CPVVLPPETR PLNGLGPPST PLDHRGYQSL SDSPPGSRVF
810 820 830
TESEKRPLSI QDSFVEVSPV CPRPRVRLGS EIRDSVV
Length:837
Mass (Da):92,766
Last modified:October 3, 2012 - v1
Checksum:i3C9F27C0E68A1E21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091167 Genomic DNA No translation available.
RefSeqiNP_064595.2, NM_020210.3
NP_945119.1, NM_198925.2
UniGeneiHs.474935

Genome annotation databases

EnsembliENST00000332496; ENSP00000332204; ENSG00000185033
ENST00000411539; ENSP00000394720; ENSG00000185033
GeneIDi10509
KEGGihsa:10509
UCSCiuc002boy.4 human

Similar proteinsi

Entry informationi

Entry nameiJ3KNP4_HUMAN
AccessioniPrimary (citable) accession number: J3KNP4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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