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Protein

Integrin beta

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotation
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160255.16.
HGNCiHGNC:6155. ITGB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160255.

PTM / Processingi

Proteomic databases

PaxDbiJ3KNI6.
PeptideAtlasiJ3KNI6.
PRIDEiJ3KNI6.

Expressioni

Gene expression databases

BgeeiENSG00000160255.
ExpressionAtlasiJ3KNI6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliJ3KNI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 65PSIInterPro annotationAdd BLAST51
Domaini23 – 322INBInterPro annotationAdd BLAST300

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR002369. Integrin_bsu_VWA.
IPR016201. PSI.
IPR002035. VWF_A.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF47. PTHR10082:SF47. 1 hit.
PfamiView protein in Pfam
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.

Sequencei

Sequence statusi: Fragment.

J3KNI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRLGKDLATG VLSQECTKFK VSSCRECIES GPGCTWCQKL NFTGPGDPDS
60 70 80 90 100
IRCDTRPQLL MRGCAADDIM DPTSLAETQE DHNGGQKQLS PQKVTLYLRP
110 120 130 140 150
GQAAAFNVTF RRAKGYPIDL YYLMDLSYSM LDDLRNVKKL GGDLLRALNE
160 170 180 190 200
ITESGRIGFG SFVDKTVLPF VNTHPDKLRN PCPNKEKECQ PPFAFRHVLK
210 220 230 240 250
LTNNSNQFQT EVGKQLISGN LDAPEGGLDA MMQVAACPEE IGWRNVTRLL
260 270 280 290 300
VFATDDGFHF AGDGKLGAIL TPNDGRCHLE DNLYKRSNEF DYPSVGQLAH
310 320
KLAENNIQPI FAVTSRMVKT YE
Length:322
Mass (Da):35,701
Last modified:October 3, 2012 - v1
Checksum:i9ECACE5FA27403CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei322Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000320216; ENSP00000317697; ENSG00000160255.
UCSCiuc062auc.1. human.

Similar proteinsi

Entry informationi

Entry nameiJ3KNI6_HUMAN
AccessioniPrimary (citable) accession number: J3KNI6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 27, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported