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Protein
Submitted name:

NACHT, LRR and PYD domains-containing protein 2

Gene

NLRP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
NACHT, LRR and PYD domains-containing protein 2Imported
Gene namesi
Name:NLRP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000022556.15.
HGNCiHGNC:22948. NLRP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022556.

Expressioni

Gene expression databases

BgeeiENSG00000022556.
ExpressionAtlasiJ3KN39. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94PyrinInterPro annotationAdd BLAST94
Domaini204 – 402NACHTInterPro annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1010 – 1041Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IM14. Eukaryota.
ENOG410ZI5C. LUCA.
GeneTreeiENSGT00900000140813.

Family and domain databases

InterProiView protein in InterPro
IPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
SMARTiView protein in SMART
SM01289. PYRIN. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.

Sequencei

Sequence statusi: Complete.

J3KN39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA
60 70 80 90 100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF
110 120 130 140 150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQETKGNVIC LGKEVFKGKK
160 170 180 190 200
PDKDNRCRYI LKTKFREMWK SWPGDSKEVQ VMAERYKMLI PFSNPRVLPG
210 220 230 240 250
PFSYTVVLYG PAGLGKTTLA QKLMLDWAED NLIHKFKYAF YLSCRELSRL
260 270 280 290 300
GPCSFAELVF RDWPELQDDI PHILAQARKI LFVIDGFDEL GAAPGALIED
310 320 330 340 350
ICGDWEKKKP VPVLLGSLLN RVMLPKAALL VTTRPRALRD LRILAEEPIY
360 370 380 390 400
IRVEGFLEED RRAYFLRHFG DEDQAMRAFE LMRSNAALFQ LGSAPAVCWI
410 420 430 440 450
VCTTLKLQME KGEDPVPTCL TRTGLFLRFL CSRFPQGAQL RGALRTLSLL
460 470 480 490 500
AAQGLWAQTS VLHREDLERL GVQESDLRLF LDGDILRQDR VSKGCYSFIH
510 520 530 540 550
LSFQQFLTAL FYTLEKEEEE DRDGHTWDIG DVQKLLSGVE RLRNPDLIQA
560 570 580 590 600
GYYSFGLANE KRAKELEATF GCRMSPDIKQ ELLRCDISCK GGHSTVTDLQ
610 620 630 640 650
ELLGCLYESQ EEELVKEVMA QFKEISLHLN AVDVVPSSFC VKHCRNLQKM
660 670 680 690 700
SLQVIKENLP ENVTASESDA EVERSQDDQH MLPFWTDLCS IFGSNKDLMG
710 720 730 740 750
LAINDSFLSA SLVRILCEQI ASDTCHLQRV VFKNISPADA HRNLCLALRG
760 770 780 790 800
HKTVTYLTLQ GNDQDDMFPA LCEVLRHPEC NLRYLGLVSC SATTQQWADL
810 820 830 840 850
SLALEVNQSL TCVNLSDNEL LDEGAKLLYT TLRHPKCFLQ RLSLENCHLT
860 870 880 890 900
EANCKDLAAV LVVSRELTHL CLAKNPIGNT GVKFLCEGLR YPECKLQTLV
910 920 930 940 950
LWNCDITSDG CCDLTKLLQE KSSLLCLDLG LNHIGVKGMK FLCEALRKPL
960 970 980 990 1000
CNLRCLWLWG CSIPPFSCED LCSALSCNQS LVTLDLGQNP LGSSGVKMLF
1010 1020 1030 1040 1050
ETLTCSSGTL RTLRLKIDDF NDELNKLLEE IEEKNPQLII DTEKHHPWAE

RPSSHDFMI
Length:1,059
Mass (Da):120,196
Last modified:October 3, 2012 - v1
Checksum:i55CAC1EF9719A3C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011476 Genomic DNA. No translation available.
RefSeqiNP_001334932.1. NM_001348003.1.
UniGeneiHs.369279.

Genome annotation databases

EnsembliENST00000263437; ENSP00000263437; ENSG00000022556.
ENST00000612740; ENSP00000479677; ENSG00000273992.
GeneIDi55655.
UCSCiuc010eso.4. human.

Similar proteinsi

Entry informationi

Entry nameiJ3KN39_HUMAN
AccessioniPrimary (citable) accession number: J3KN39
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported