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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

CIMG_02339

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CIMG_02339), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CIMG_06614), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (CIMG_05754)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein, UbiquinoneImported

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:CIMG_02339Imported
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)Imported
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:CIMG_02339

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi246410.XP_001248568.1

Structurei

3D structure databases

ProteinModelPortaliJ3KL57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 457FAD_binding_2InterPro annotationAdd BLAST396
Domaini512 – 647Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiENOG410IH87 Eukaryota
ENOG410XRU5 LUCA
InParanoidiJ3KL57
KOiK00234
OrthoDBiEOG092C14N7

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

J3KL57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNGLRSLA PATRFSRSLR DQRRLFSSSR PAARIITSQP LRAKEASPFL
60 70 80 90 100
TKKYPVIDHE YDAVVVGAGG AGLRAAFGLA EAGFNTACVT KLFPTRSHTV
110 120 130 140 150
AAQGGINAAL GNMHEDDWRW HMYDTVKGSD WLGDQDAIHY MTREAPQSVI
160 170 180 190 200
ELEGYGCPFS RTEDGKIYQR AFGGQSKEFG KGGQAYRCCA AADRTGHALL
210 220 230 240 250
HTLYGQSLRY NASYFIEYFA LDLLMENGEC KGILAYNQED GTLHRFKAHH
260 270 280 290 300
TVLATGGYGR AYFSCTSAHT CTGDGMAMVA RAGLPNQDLE FVQFHPTGIY
310 320 330 340 350
GAGCLITEGA RGEGGYLLNS NGERFMERYA STAKDLASRD VVSRSMTLEI
360 370 380 390 400
REGRGVGPEK DHIYLQLSHL PPEILHERLP GISETASIFA GVDVTKQPIP
410 420 430 440 450
VLPTVHYNMG GIPTRYTGEV LTIDEKGNDK IVPGLYACGE AACVSVHGAN
460 470 480 490 500
RLGANSLLDL IVFGRAVSHT IRDNATPNTP HKEISADAGA ESIEVLDKIR
510 520 530 540 550
TADGPKSTFD IRNAMQKTMQ TDVSVFRTQE SLDEGVRKIN EVDQMFAQVG
560 570 580 590 600
TKDRSMIWNS DLVETLELRN LLTCATQTAV AAANRKESRG AHAREDYPDR
610 620 630 640
DDANWMKHTL TFQKEPHGKV DLTYRAVTQT TLDESECKPV PPFKRVY
Length:647
Mass (Da):71,154
Last modified:May 27, 2015 - v2
Checksum:i232F55322AC6067A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA Translation: EAS36985.3
RefSeqiXP_001248568.1, XM_001248567.2

Genome annotation databases

EnsemblFungiiEAS36985; EAS36985; CIMG_02339
GeneIDi4566571
KEGGicim:CIMG_02339

Similar proteinsi

Entry informationi

Entry nameiJ3KL57_COCIM
AccessioniPrimary (citable) accession number: J3KL57
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: May 27, 2015
Last modified: March 28, 2018
This is version 34 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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