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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

CIMG_01466

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi202 – 2021IronUniRule annotation
Metal bindingi285 – 2851IronUniRule annotation
Metal bindingi368 – 3681IronUniRule annotation

GO - Molecular functioni

  1. 4-hydroxyphenylpyruvate dioxygenase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DioxygenaseImported, Oxidoreductase

Keywords - Ligandi

IronUniRule annotation, Metal-bindingUniRule annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenaseUniRule annotation
Gene namesi
ORF Names:CIMG_01466Imported
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)Imported
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliJ3KJI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4HPPD family.UniRule annotation

Phylogenomic databases

InParanoidiJ3KJI5.
KOiK04564.
OrthoDBiEOG7FBRSJ.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

Sequencei

Sequence statusi: Complete.

J3KJI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLEGLKPE IALRFGPGYV GFDHVTWYVG NAKQTASYYI SRMNFTQIAY
60 70 80 90 100
KGPENGSPYI ASYVVENGDA RFVFIAPICG PTDESVPESE KILLREIHEH
110 120 130 140 150
LTKHGDGVKD IAFRVTTDVK EIWDKAVKHG ARPVADPTIV QSESPFSGEI
160 170 180 190 200
QMATIGAYGD TTHTFINRET YNGPFLPGYT IVNERDLINN HLPAVNFIDI
210 220 230 240 250
DHCVGNQPWN GVDKAVKFYE ECLDFHRYWS VDDNLMCSDY SAMRSIVIAS
260 270 280 290 300
PDEVIKMPLN EPAVGKKRSQ IEEFVDYYNG AGVQHIAFRT DDIITAVTNL
310 320 330 340 350
RERGMQFLSV PTTYYTEIRE KLDQSNLVLN ESVELLQKLN ILIDFDEGGY
360 370 380 390 400
LLQIFAKHVL DRPTVFIEII QRNNFDGFGA GNFKALFQAF EREQALRGNL
Length:400
Mass (Da):45,197
Last modified:October 3, 2012 - v1
Checksum:i0FE8B217958E924F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS36233.2.
RefSeqiXP_001247816.1. XM_001247815.1.

Genome annotation databases

GeneIDi4567315.
KEGGicim:CIMG_01587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS36233.2.
RefSeqiXP_001247816.1. XM_001247815.1.

3D structure databases

ProteinModelPortaliJ3KJI5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4567315.
KEGGicim:CIMG_01587.

Phylogenomic databases

InParanoidiJ3KJI5.
KOiK04564.
OrthoDBiEOG7FBRSJ.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSImported.
  2. Cited for: GENOME REANNOTATION.
    Strain: RSImported.

Entry informationi

Entry nameiJ3KJI5_COCIM
AccessioniPrimary (citable) accession number: J3KJI5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: March 4, 2015
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.