J3KJI5 (J3KJI5_COCIM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase PIRNR PIRNR009283

Gene names

ORF Names:

CIMG_01466 EMBL EAS36233.2

Organism

Coccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome] EMBL EAS36233.2

Taxonomic identifier

246410 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides immitis

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 iron ion per subunit By similarity. PIRSR PIRSR009283-1
Sequence similarities	Belongs to the 4HPPD family. PIRNR PIRNR009283 PIRSR PIRSR009283-1

Ontologies

Keywords
Ligand	Iron PIRSR PIRSR009283-1 Metal-binding PIRSR PIRSR009283-1 Pyruvate EMBL EAS36233.2
Molecular function	Dioxygenase EMBL EAS36233.2 Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	202	1	Iron By similarity PIRSR PIRSR009283-1
	Metal binding	285	1	Iron By similarity PIRSR PIRSR009283-1
	Metal binding	368	1	Iron By similarity PIRSR PIRSR009283-1

Sequences

	Sequence		Length	Mass (Da)
	J3KJI5 [UniParc]. Last modified October 3, 2012. Version 1. Checksum: 0FE8B217958E924F	FASTA	400	45,197
	10 20 30 40 50 60 MPGLEGLKPE IALRFGPGYV GFDHVTWYVG NAKQTASYYI SRMNFTQIAY KGPENGSPYI 70 80 90 100 110 120 ASYVVENGDA RFVFIAPICG PTDESVPESE KILLREIHEH LTKHGDGVKD IAFRVTTDVK 130 140 150 160 170 180 EIWDKAVKHG ARPVADPTIV QSESPFSGEI QMATIGAYGD TTHTFINRET YNGPFLPGYT 190 200 210 220 230 240 IVNERDLINN HLPAVNFIDI DHCVGNQPWN GVDKAVKFYE ECLDFHRYWS VDDNLMCSDY 250 260 270 280 290 300 SAMRSIVIAS PDEVIKMPLN EPAVGKKRSQ IEEFVDYYNG AGVQHIAFRT DDIITAVTNL 310 320 330 340 350 360 RERGMQFLSV PTTYYTEIRE KLDQSNLVLN ESVELLQKLN ILIDFDEGGY LLQIFAKHVL 370 380 390 400 DRPTVFIEII QRNNFDGFGA GNFKALFQAF EREQALRGNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.
[2]	"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control." Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. , Lui A., Macdonald J.P., Priest M., Orbach M.J., Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., Taylor J.W., Rounsley S.D. Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG704911 Genomic DNA. Translation: EAS36233.2.
RefSeq	XP_001247816.1. XM_001247815.1.
3D structure databases
ProteinModelPortal	J3KJI5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4567315.
KEGG	cim:CIMG_01587.
Phylogenomic databases
KO	K04564.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase_dom. [Graphical view]
PANTHER	PTHR11959. PTHR11959. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

J3KJI5_COCIM

Accession

Primary (citable) accession number: J3KJI5

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2012
Last sequence update:	October 3, 2012
Last modified:	February 6, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)