ID J3KH04_COCIM Unreviewed; 742 AA. AC J3KH04; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 2. DT 27-MAR-2024, entry version 64. DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:EAS35087.3}; GN ORFNames=CIMG_00441 {ECO:0000313|EMBL:EAS35087.3}; OS Coccidioides immitis (strain RS) (Valley fever fungus). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides. OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS35087.3, ECO:0000313|Proteomes:UP000001261}; RN [1] {ECO:0000313|Proteomes:UP000001261} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261}; RX PubMed=19717792; DOI=10.1101/gr.087551.108; RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T., RA Henn M.R., Birren B.W., Taylor J.W.; RT "Comparative genomic analyses of the human fungal pathogens Coccidioides RT and their relatives."; RL Genome Res. 19:1722-1731(2009). RN [2] {ECO:0000313|Proteomes:UP000001261} RP GENOME REANNOTATION. RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261}; RX PubMed=20516208; DOI=10.1101/gr.103911.109; RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J., RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., RA Taylor J.W., Rounsley S.D.; RT "Population genomic sequencing of Coccidioides fungi reveals recent RT hybridization and transposon control."; RL Genome Res. 20:938-946(2010). CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG704911; EAS35087.3; -; Genomic_DNA. DR RefSeq; XP_001246670.1; XM_001246669.2. DR AlphaFoldDB; J3KH04; -. DR STRING; 246410.J3KH04; -. DR GeneID; 4566138; -. DR KEGG; cim:CIMG_00441; -. DR VEuPathDB; FungiDB:CIMG_00441; -. DR InParanoid; J3KH04; -. DR OMA; NCQNRYM; -. DR OrthoDB; 950362at2759; -. DR Proteomes; UP000001261; Unassembled WGS sequence. DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR Gene3D; 2.170.270.10; SET domain; 1. DR InterPro; IPR006560; AWS_dom. DR InterPro; IPR003616; Post-SET_dom. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR PANTHER; PTHR22884:SF512; N-METHYLTRANSFERASE (ASH1), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06480)-RELATED; 1. DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1. DR Pfam; PF17907; AWS; 1. DR Pfam; PF00856; SET; 1. DR SMART; SM00570; AWS; 1. DR SMART; SM00508; PostSET; 1. DR SMART; SM00317; SET; 1. DR SUPFAM; SSF82199; SET domain; 1. DR PROSITE; PS51215; AWS; 1. DR PROSITE; PS50868; POST_SET; 1. DR PROSITE; PS50280; SET; 1. PE 4: Predicted; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603}; KW Reference proteome {ECO:0000313|Proteomes:UP000001261}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 341..388 FT /note="AWS" FT /evidence="ECO:0000259|PROSITE:PS51215" FT DOMAIN 399..515 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT DOMAIN 523..539 FT /note="Post-SET" FT /evidence="ECO:0000259|PROSITE:PS50868" FT REGION 1..149 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 171..236 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 260..280 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 540..673 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 697..742 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 7..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 30..44 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 88..121 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 171..201 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 219..235 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 542..576 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 608..637 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 646..660 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 742 AA; 81952 MW; 77768818AE806A65 CRC64; MARDPMLSPS STPTSSALDS DATAIDATVP VLTPATSISE QSTPVDTEKD GEHRAKKAKA SRRVTRSSLK NGELEANGGG EAMVTRPNDE SLDNTNTQED EDCTSLLNGA EDASGSVDKW SSKNAEAAGK KPNKKAGNKS PKRRSTRLSL LAKTMDLAQS APSVLGKRTL DAISKSKDKV KTIDRKASLR PRVENEKKEA STPAPQEPSP KKRRVSGDNK STCQVPRQEQ TATRENSLIR QKRKPWLKHG LYAGQEYIDS SVPKSKRGTR DAKNNGQQSQ VFPFPMYAGA RLLENGRAYK LPFDIFSPLP HGQPKPNEWR KANKNVFVGD AASIWKAAKI KEHSTCTCTP ETGCDENCQN RYMFYECDDT NCKLGSELCR NRPFSALRRR AKAGGKFNIG VEVIKTEDRG YGVRSNRSFD PNQIIVEYTG EILTQEECER RMRTVYKKNE CYYLMYFDQN MVIDATRGSI ARFINHSCEP NCRMEKWTVA GKPRMALFAG EDGIMTGEEL TYDYNFDPYS QKNVQECRCG APTCRGVLGP RPKESWKNKD KEKKSAPAAK RKVDSALDES ASRLNKKPKP SRASSLKTGI KKAVSKARTA LKSTQTKGKV KRVGRPAKKA VSIKPIPVKK RRSTLTRAKM PVKSASKSAE GDEKPPRNKG RKLKMPSKPR LGNSIAAARA SNKTPALMRK FLEAGDTKGG AKVVSDTIKP GRKTRAARTA DVRSSPDNVP VSRKRGRAKK TS //