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Protein
Submitted name:

Histone-lysine N-methyltransferase

Gene

CIMG_00441

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseSAAS annotationImported, Transferase
LigandS-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferaseImported
Gene namesi
ORF Names:CIMG_00441Imported
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)Imported
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_00441.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi246410.XP_001246653.1.

Structurei

3D structure databases

ProteinModelPortaliJ3KH04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini341 – 388AWSInterPro annotationAdd BLAST48
Domaini399 – 515SETInterPro annotationAdd BLAST117
Domaini523 – 539Post-SETInterPro annotationAdd BLAST17

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.SAAS annotation

Phylogenomic databases

eggNOGiKOG3089. Eukaryota.
ENOG410XPW6. LUCA.
InParanoidiJ3KH04.
KOiK06101.
OrthoDBiEOG092C4OUK.

Family and domain databases

InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

J3KH04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDPMLSPS STPTSSALDS DATAIDATVP VLTPATSISE QSTPVDTEKD
60 70 80 90 100
GEHRAKKAKA SRRVTRSSLK NGELEANGGG EAMVTRPNDE SLDNTNTQED
110 120 130 140 150
EDCTSLLNGA EDASGSVDKW SSKNAEAAGK KPNKKAGNKS PKRRSTRLSL
160 170 180 190 200
LAKTMDLAQS APSVLGKRTL DAISKSKDKV KTIDRKASLR PRVENEKKEA
210 220 230 240 250
STPAPQEPSP KKRRVSGDNK STCQVPRQEQ TATRENSLIR QKRKPWLKHG
260 270 280 290 300
LYAGQEYIDS SVPKSKRGTR DAKNNGQQSQ VFPFPMYAGA RLLENGRAYK
310 320 330 340 350
LPFDIFSPLP HGQPKPNEWR KANKNVFVGD AASIWKAAKI KEHSTCTCTP
360 370 380 390 400
ETGCDENCQN RYMFYECDDT NCKLGSELCR NRPFSALRRR AKAGGKFNIG
410 420 430 440 450
VEVIKTEDRG YGVRSNRSFD PNQIIVEYTG EILTQEECER RMRTVYKKNE
460 470 480 490 500
CYYLMYFDQN MVIDATRGSI ARFINHSCEP NCRMEKWTVA GKPRMALFAG
510 520 530 540 550
EDGIMTGEEL TYDYNFDPYS QKNVQECRCG APTCRGVLGP RPKESWKNKD
560 570 580 590 600
KEKKSAPAAK RKVDSALDES ASRLNKKPKP SRASSLKTGI KKAVSKARTA
610 620 630 640 650
LKSTQTKGKV KRVGRPAKKA VSIKPIPVKK RRSTLTRAKM PVKSASKSAE
660 670 680 690 700
GDEKPPRNKG RKLKMPSKPR LGNSIAAARA SNKTPALMRK FLEAGDTKGG
710 720 730 740
AKVVSDTIKP GRKTRAARTA DVRSSPDNVP VSRKRGRAKK TS
Length:742
Mass (Da):81,952
Last modified:May 27, 2015 - v2
Checksum:i77768818AE806A65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS35087.3.
RefSeqiXP_001246670.1. XM_001246669.2.

Genome annotation databases

EnsemblFungiiEAS35087; EAS35087; CIMG_00441.
GeneIDi4566138.
KEGGicim:CIMG_00441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS35087.3.
RefSeqiXP_001246670.1. XM_001246669.2.

3D structure databases

ProteinModelPortaliJ3KH04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246410.XP_001246653.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAS35087; EAS35087; CIMG_00441.
GeneIDi4566138.
KEGGicim:CIMG_00441.

Organism-specific databases

EuPathDBiFungiDB:CIMG_00441.

Phylogenomic databases

eggNOGiKOG3089. Eukaryota.
ENOG410XPW6. LUCA.
InParanoidiJ3KH04.
KOiK06101.
OrthoDBiEOG092C4OUK.

Family and domain databases

InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiJ3KH04_COCIM
AccessioniPrimary (citable) accession number: J3KH04
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: May 27, 2015
Last modified: April 12, 2017
This is version 29 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.