ID   J3K764_COCIM            Unreviewed;       890 AA.
AC   J3K764;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=K+ homeostasis protein Kha1 {ECO:0000313|EMBL:EAS30502.3};
GN   ORFNames=CIMG_05981 {ECO:0000313|EMBL:EAS30502.3};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS30502.3, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; GG704912; EAS30502.3; -; Genomic_DNA.
DR   RefSeq; XP_001242085.2; XM_001242084.2.
DR   AlphaFoldDB; J3K764; -.
DR   STRING; 246410.J3K764; -.
DR   GeneID; 4561571; -.
DR   KEGG; cim:CIMG_05981; -.
DR   VEuPathDB; FungiDB:CIMG_05981; -.
DR   InParanoid; J3K764; -.
DR   OMA; QVKVERW; -.
DR   OrthoDB; 6504at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        45..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        107..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        211..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..442
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   890 AA;  95948 MW;  CD8B872E8F4065A2 CRC64;
     MASVVAQTGT VGGSAAPAAP TNRATPQGGI FDHLNPSQYD PKNPLTLFII QASIIVIFCR
     LLHFPLSKIR QPRVISEVIG GILLGPSVMG RIPGFRDAIF PEESLPNLNL VANLGLVLFL
     FMIGVETNIK TLTSNWKVAV GVSAAGMILP FGLGCGIAYG LYHEFRNDPG LAPISFGTYM
     LFIGIAMAIT AFPVLCRILT ELELLNTNVG VIVLSAGVGN DVVGWVLLAL CVALVNANTG
     ITALWVLLAC IGFTLFLIYA VRPVFHWFLK RTGSLHDGPN QSVVALTLLL ALAAAFFTQV
     IGVHAIFGGF LVGIICPHDG GFAIKLTEKI EDVIGALFLP LYFALSGLNT NVGLLNSGIV
     WGYVFAVVFI AFIAKVTGGM LASRFHGLLW RESATIGVLM SCKGLVELIV LNIGLQAKIL
     SSRTFTIFIV MALITTFATT PLTLWLYPEW YQTKVDRWRR GEIDWDGNVL DSESDHSGGS
     SDLAQQKARS LSIRKLMVYL RLDNLPGLFT FISLLGADDM TTVEVSKTHH SHDSNGVDRS
     TSAKRNKPVE VHGIRLIELT DRDSSVMKVS EVHDYSFSDP ILNTFRTFAQ LNRVAVSGAV
     VIAPEHAYAE TLVNKARDFS SDFMLIPWSE RQIPFLDVNS EKFATGPHST FISNILKNSK
     SHVGILVNNG FGGPALTQPK PGYLKRTISG RSLYRTNDLA MMPSMEDGHH IFFPYFGGDD
     DQVALRLVLQ LAKNATITAT IAHVVLDDTD TPASSSKNPA VFYGLTMAPE EKEADSAFFN
     TIRDSLPSEL APRVIFQTIH VTTTDLISAT LQTAKLDVGK SNQNRGDIVI VGRNSVVHGT
     GSSFGLATSA QSGEIGSEAR KALGVLGESM ATNANDVKAS VLVVQAGKEG
//