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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Bartonella doshiae NCTC 12862 = ATCC 700133
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. Succinyl-diaminopimelate desuccinylase (dapE)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
ORF Names:MCS_00979Imported
OrganismiBartonella doshiae NCTC 12862 = ATCC 700133Imported
Taxonomic identifieri1094553 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000008945 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 72THDPS_N_2InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H0G02.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD. 1 hit.
InterProiView protein in InterPro
IPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR037133. THP_succinylTrfase_N_sf.
IPR011004. Trimer_LpxA-like_sf.
PfamiView protein in Pfam
PF00132. Hexapep. 1 hit.
PF14602. Hexapep_2. 1 hit.
PF14805. THDPS_N_2. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.
PROSITEiView protein in PROSITE
PS00101. HEXAPEP_TRANSFERASES. 1 hit.

Sequencei

Sequence statusi: Complete.

J0QC25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLTQLEMI IEKAFDDRNS INTITKGEAR ESVEHALNLL DKGEVRVAER
60 70 80 90 100
QKNGQWHVHQ WLKKAVLLSF RLNPMQIIAG GINGTYWWDK IPSKFSGWQE
110 120 130 140 150
ADFTKADFRS VPGAIVRHSA YIAPNVILMP SFVNLGAFID EGTMVDAWAT
160 170 180 190 200
VGSCAQIGKH VHLSGGVGIG GVLEPLQANP TIIEDHCFIG ARSEVVEGCI
210 220 230 240 250
IREGAVLGMG VFIGKSTKII DRITGEVFIG EVPAYSVVVP GSLPGKPLPN
260 270 280
GEAGPNLYCA VIVKRVDQRT REKTSINDLL RD
Length:282
Mass (Da):30,785
Last modified:October 3, 2012 - v1
Checksum:i29671392F89F8045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AILV01000008 Genomic DNA. Translation: EJF80329.1.
RefSeqiWP_004856157.1. NZ_JH725096.1.

Genome annotation databases

EnsemblBacteriaiEJF80329; EJF80329; MCS_00979.
PATRICifig|1094553.3.peg.1056.

Similar proteinsi

Entry informationi

Entry nameiJ0QC25_BARDO
AccessioniPrimary (citable) accession number: J0QC25
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 22, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported