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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Helicobacter pylori Hp A-27
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotationImported
ORF Names:HPHPA27_1306Imported
OrganismiHelicobacter pylori Hp A-27Imported
Taxonomic identifieri992057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000003215 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 83HelicalUniRule annotationAdd BLAST23
Transmembranei104 – 127HelicalUniRule annotationAdd BLAST24
Transmembranei139 – 160HelicalUniRule annotationAdd BLAST22
Transmembranei172 – 193HelicalUniRule annotationAdd BLAST22
Transmembranei199 – 223HelicalUniRule annotationAdd BLAST25
Transmembranei255 – 277HelicalUniRule annotationAdd BLAST23
Transmembranei297 – 315HelicalUniRule annotationAdd BLAST19
Transmembranei356 – 374HelicalUniRule annotationAdd BLAST19
Transmembranei380 – 397HelicalUniRule annotationAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI9U164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Gene3Di1.10.3370.101 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

I9U164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKAIASKIL ITLGFLFLYR VLAYIPIPGV DLAAIKAFFD SNSNNALGLF
60 70 80 90 100
NMFSGNAVSR LSIISLGIMP YITSSIIMEL LSATFPNLAK MKKERDGMQK
110 120 130 140 150
YMQIVRYLTI LITLIQAVSV SVGLRSISGG ANGAIMIDMQ VFMIVSAFSM
160 170 180 190 200
LTGTMLLMWI GEQITQRGVG NGISLIIFAG IVSGIPSAIS GTFNLVNTGV
210 220 230 240 250
INILMLIGIV LIVLATIFAI IYVELAERRI PISYARKVVM QNQNKRIMNY
260 270 280 290 300
IPIKLNLSGV IPPIFASALL VFPSTILQQA TSNKTLQAVA DFLSPQGYAY
310 320 330 340 350
NILMFLLIIF FAYFYSSIVF NSKDIADNLR RNGGYIPGLR PGEGTSSFLN
360 370 380 390 400
SVASKLTLWG SLYLALISTV PWILVKAMGV PFYFGGTAVL IVVQVAIDTM
410 420
KKIEAQIYMS KYKTLSAVGF
Length:420
Mass (Da):45,829
Last modified:October 3, 2012 - v1
Checksum:i9FD337091D905F9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKOW01000004 Genomic DNA Translation: EJB75706.1
RefSeqiWP_001030187.1, NZ_AKOW01000004.1

Genome annotation databases

EnsemblBacteriaiEJB75706; EJB75706; HPHPA27_1306
PATRICifig|992057.3.peg.1269

Similar proteinsi

Entry informationi

Entry nameiI9U164_HELPX
AccessioniPrimary (citable) accession number: I9U164
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported