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I7MK25

- I7MK25_TETTS

UniProt

I7MK25 - I7MK25_TETTS

Protein
Submitted name:

Eukaryotic translation initiation factor 1A

Gene

TTHERM_00497990

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 12 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factorUniRule annotationImported

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Eukaryotic translation initiation factor 1AImported
    Gene namesi
    ORF Names:TTHERM_00497990Imported
    OrganismiTetrahymena thermophila (strain SB210)Imported
    Taxonomic identifieri312017 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
    ProteomesiUP000009168: Unassembled WGS sequence

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BPEX-ray3.7002-193[»]
    4BPNX-ray3.7002-193[»]
    4BPOX-ray3.7002-193[»]
    4BPPX-ray3.7002-193[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-1A family.UniRule annotation
    Contains 1 S1-like domain.UniRule annotation

    Phylogenomic databases

    KOiK03236.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00216. aIF_1A.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006196. RNA-binding_domain_S1_IF1.
    IPR001253. TIF_eIF-1A.
    IPR018104. TIF_eIF-1A_CS.
    [Graphical view]
    PANTHERiPTHR21668. PTHR21668. 1 hit.
    PfamiPF01176. eIF-1a. 1 hit.
    [Graphical view]
    ProDomiPD005579. TIF_eIF-1A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00652. eIF1a. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
    PROSITEiPS01262. IF1A. 1 hit.
    PS50832. S1_IF1_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I7MK25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKNKGRGGK NYRRGKNENE TKRELVFKEE GMEYAQVIKM LGNGRLEVFC    50
    FDGKRRIGHI CGRLKKKVWI SMDDIVLVGL RDFQDDKCDI LLKYLPDEVR 100
    NLKQYGEIDE NIKINDKSGA DQADVVFEDS DSDDKDDDDD DEDEQPTRQT 150
    NTRVNQMVES SDEEDNKETG NYEEQKYDQK HQNKKDDIDI DDI 193
    Length:193
    Mass (Da):22,550
    Last modified:October 3, 2012 - v1
    Checksum:iDDD89D7A6FF2C018
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG662212 Genomic DNA. Translation: EAS07745.3.
    RefSeqiXP_001027987.3. XM_001027987.3.
    UniGeneiTth.5318.

    Genome annotation databases

    EnsemblProtistsiEAS07745; EAS07745; TTHERM_00497990.
    GeneIDi7835355.
    KEGGitet:TTHERM_00497990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG662212 Genomic DNA. Translation: EAS07745.3 .
    RefSeqi XP_001027987.3. XM_001027987.3.
    UniGenei Tth.5318.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BPE X-ray 3.70 0 2-193 [» ]
    4BPN X-ray 3.70 0 2-193 [» ]
    4BPO X-ray 3.70 0 2-193 [» ]
    4BPP X-ray 3.70 0 2-193 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi EAS07745 ; EAS07745 ; TTHERM_00497990 .
    GeneIDi 7835355.
    KEGGi tet:TTHERM_00497990.

    Phylogenomic databases

    KOi K03236.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00216. aIF_1A.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006196. RNA-binding_domain_S1_IF1.
    IPR001253. TIF_eIF-1A.
    IPR018104. TIF_eIF-1A_CS.
    [Graphical view ]
    PANTHERi PTHR21668. PTHR21668. 1 hit.
    Pfami PF01176. eIF-1a. 1 hit.
    [Graphical view ]
    ProDomi PD005579. TIF_eIF-1A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00652. eIF1a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00523. eIF-1A. 1 hit.
    PROSITEi PS01262. IF1A. 1 hit.
    PS50832. S1_IF1_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
      Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
      , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
      PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB210Imported.
    2. "The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A."
      Weisser M., Voigts-Hoffmann F., Rabl J., Leibundgut M., Ban N.
      Nat. Struct. Mol. Biol. 20:1015-1017(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 2-193.

    Entry informationi

    Entry nameiI7MK25_TETTS
    AccessioniPrimary (citable) accession number: I7MK25
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3