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I7MK25

- I7MK25_TETTS

UniProt

I7MK25 - I7MK25_TETTS

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Protein
Submitted name:

Eukaryotic translation initiation factor 1A

Gene

TTHERM_00497990

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 1AImported
Gene namesi
ORF Names:TTHERM_00497990Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BPEX-ray3.7002-193[»]
4BPNX-ray3.7002-193[»]
4BPOX-ray3.7002-193[»]
4BPPX-ray3.7002-193[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-1A family.UniRule annotation
Contains 1 S1-like domain.UniRule annotation

Phylogenomic databases

InParanoidiI7MK25.
KOiK03236.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00216. aIF_1A.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomiPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I7MK25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKNKGRGGK NYRRGKNENE TKRELVFKEE GMEYAQVIKM LGNGRLEVFC
60 70 80 90 100
FDGKRRIGHI CGRLKKKVWI SMDDIVLVGL RDFQDDKCDI LLKYLPDEVR
110 120 130 140 150
NLKQYGEIDE NIKINDKSGA DQADVVFEDS DSDDKDDDDD DEDEQPTRQT
160 170 180 190
NTRVNQMVES SDEEDNKETG NYEEQKYDQK HQNKKDDIDI DDI
Length:193
Mass (Da):22,550
Last modified:October 3, 2012 - v1
Checksum:iDDD89D7A6FF2C018
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662212 Genomic DNA. Translation: EAS07745.3.
RefSeqiXP_001027987.3. XM_001027987.3.
UniGeneiTth.5318.

Genome annotation databases

EnsemblProtistsiEAS07745; EAS07745; TTHERM_00497990.
GeneIDi7835355.
KEGGitet:TTHERM_00497990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662212 Genomic DNA. Translation: EAS07745.3 .
RefSeqi XP_001027987.3. XM_001027987.3.
UniGenei Tth.5318.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BPE X-ray 3.70 0 2-193 [» ]
4BPN X-ray 3.70 0 2-193 [» ]
4BPO X-ray 3.70 0 2-193 [» ]
4BPP X-ray 3.70 0 2-193 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAS07745 ; EAS07745 ; TTHERM_00497990 .
GeneIDi 7835355.
KEGGi tet:TTHERM_00497990.

Phylogenomic databases

InParanoidi I7MK25.
KOi K03236.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00216. aIF_1A.
InterProi IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view ]
PANTHERi PTHR21668. PTHR21668. 1 hit.
Pfami PF01176. eIF-1a. 1 hit.
[Graphical view ]
ProDomi PD005579. TIF_eIF-1A. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00652. eIF1a. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00523. eIF-1A. 1 hit.
PROSITEi PS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.
  2. "The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A."
    Weisser M., Voigts-Hoffmann F., Rabl J., Leibundgut M., Ban N.
    Nat. Struct. Mol. Biol. 20:1015-1017(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 2-193.

Entry informationi

Entry nameiI7MK25_TETTS
AccessioniPrimary (citable) accession number: I7MK25
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3