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I7MK25

- I7MK25_TETTS

UniProt

I7MK25 - I7MK25_TETTS

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Protein
Submitted name: Eukaryotic translation initiation factor 1A
Gene
TTHERM_00497990
Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits By similarity.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 1AImported
Gene namesi
ORF Names:TTHERM_00497990Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BPEX-ray3.7002-193[»]
4BPNX-ray3.7002-193[»]
4BPOX-ray3.7002-193[»]
4BPPX-ray3.7002-193[»]

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-1A family.UniRule annotation
Contains 1 S1-like domain.UniRule annotation

Phylogenomic databases

KOiK03236.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00216. aIF_1A.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomiPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I7MK25-1 [UniParc]FASTAAdd to Basket

« Hide

MPKNKGRGGK NYRRGKNENE TKRELVFKEE GMEYAQVIKM LGNGRLEVFC    50
FDGKRRIGHI CGRLKKKVWI SMDDIVLVGL RDFQDDKCDI LLKYLPDEVR 100
NLKQYGEIDE NIKINDKSGA DQADVVFEDS DSDDKDDDDD DEDEQPTRQT 150
NTRVNQMVES SDEEDNKETG NYEEQKYDQK HQNKKDDIDI DDI 193
Length:193
Mass (Da):22,550
Last modified:October 3, 2012 - v1
Checksum:iDDD89D7A6FF2C018
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662212 Genomic DNA. Translation: EAS07745.3.
RefSeqiXP_001027987.3. XM_001027987.3.
UniGeneiTth.5318.

Genome annotation databases

EnsemblProtistsiEAS07745; EAS07745; TTHERM_00497990.
GeneIDi7835355.
KEGGitet:TTHERM_00497990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662212 Genomic DNA. Translation: EAS07745.3 .
RefSeqi XP_001027987.3. XM_001027987.3.
UniGenei Tth.5318.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BPE X-ray 3.70 0 2-193 [» ]
4BPN X-ray 3.70 0 2-193 [» ]
4BPO X-ray 3.70 0 2-193 [» ]
4BPP X-ray 3.70 0 2-193 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAS07745 ; EAS07745 ; TTHERM_00497990 .
GeneIDi 7835355.
KEGGi tet:TTHERM_00497990.

Phylogenomic databases

KOi K03236.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00216. aIF_1A.
InterProi IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view ]
PANTHERi PTHR21668. PTHR21668. 1 hit.
Pfami PF01176. eIF-1a. 1 hit.
[Graphical view ]
ProDomi PD005579. TIF_eIF-1A. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00652. eIF1a. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00523. eIF-1A. 1 hit.
PROSITEi PS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210.
  2. "The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A."
    Weisser M., Voigts-Hoffmann F., Rabl J., Leibundgut M., Ban N.
    Nat. Struct. Mol. Biol. 20:1015-1017(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 2-193.

Entry informationi

Entry nameiI7MK25_TETTS
AccessioniPrimary (citable) accession number: I7MK25
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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