ID   I7LP05_HUMAN            Unreviewed;       255 AA.
AC   I7LP05;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:CCJ47270.1};
GN   Name=HLA-DQA1 {ECO:0000313|EMBL:CCJ47270.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CCJ47270.1};
RN   [1] {ECO:0000313|EMBL:CCJ47270.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Witter K.;
RT   "Group-specific amplification of HLA-DQA1 revealed a number of genomic full
RT   length sequences including the novel allele DQA1*01:new.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004352}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|RuleBase:RU004238}.
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DR   EMBL; HE965627; CCJ47270.1; -; Genomic_DNA.
DR   AlphaFoldDB; I7LP05; -.
DR   SMR; I7LP05; -.
DR   PeptideAtlas; I7LP05; -.
DR   ChiTaRS; HLA-DQA1; human.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   CDD; cd21008; IgC1_MHC_II_alpha_HLA-DQ; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   PANTHER; PTHR19944:SF59; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..255
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003711702"
FT   TRANSMEM        222..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          113..193
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   255 AA;  27947 MW;  49300396B1F47116 CRC64;
     MILNKALLLG ALALTTVMSP CGGEDIVADH VASCGVNLYQ FYGPSGQFTH EFDGDEQFYV
     DLEKKETAWR WPEFSKFGGF DPQGALRNMA VAKHNLNIMI KRYNSTTATN EVPEVTVFSK
     SPVTLGQPNT LICLVDNIFP PVVNITWLSN GHAVTEGVSE TSFLSKSDHS FFKISYLTFL
     PSADEIYDCK VEHWGLDQPL LKHWEPEIPA PMSELTETVV CALGLSVGLV GIVVGTVFII
     QGLRSVGASR HQGPL
//