rbcL

Functionⁱ

Catalyzes the addition of molecular CO₂ and H₂O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O₂ to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Catalytic activityⁱ

2 3-phospho-D-glycerate + 2 H⁺ = D-ribulose 1,5-bisphosphate + CO₂ + H₂O.UniRule annotation

3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O₂.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotationNote: Binds 1 Mg²⁺ ion per subunit.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	152	Proton acceptorUniRule annotation	1
Binding siteⁱ	154	SubstrateUniRule annotation	1
Metal bindingⁱ	178	Magnesium; via carbamate groupUniRule annotation	1
Metal bindingⁱ	180	MagnesiumUniRule annotation	1
Metal bindingⁱ	181	MagnesiumUniRule annotation	1
Active siteⁱ	270	Proton acceptorUniRule annotation	1
Binding siteⁱ	271	SubstrateUniRule annotation	1
Binding siteⁱ	303	SubstrateUniRule annotation	1
Siteⁱ	310	Transition state stabilizerUniRule annotation	1

GO - Molecular functionⁱ

magnesium ion binding Source: UniProtKB-HAMAP
oxidoreductase activity Source: UniProtKB-KW
ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

AMP catabolic process Source: UniProtKB-HAMAP
carbon fixation Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	LyaseUniRule annotationImported, OxidoreductaseUniRule annotation
Biological process	Carbon dioxide fixationUniRule annotation
Ligand	MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCycⁱ	MBOU1201294:GLGD-2167-MONOMER.

BioCycⁱ

MBOU1201294:GLGD-2167-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation) Short name: RuBisCOUniRule annotation
Gene namesⁱ	Name:rbcLUniRule annotationImported Ordered Locus Names:BN140_2166Imported
Organismⁱ	Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)Imported
Taxonomic identifierⁱ	1201294 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus › Methanoculleus bourgensis
Proteomesⁱ	UP000009007 Componentⁱ: Chromosome

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	178	N6-carboxylysineUniRule annotation		1

Interactionⁱ

Subunit structureⁱ

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	I7LNH2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 121	RuBisCO_large_NInterPro annotationAdd BLAST		114
Domainⁱ	132 – 424	RuBisCO_largeInterPro annotationAdd BLAST		293

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	353 – 355	Substrate bindingUniRule annotation		3

Sequence similaritiesⁱ

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01601.
OMAⁱ	HRAMHAA.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z02MJ.

Family and domain databases

Gene3Dⁱ	3.20.20.110. 1 hit. 3.30.70.150. 1 hit.
HAMAPⁱ	MF_01133. RuBisCO_L_type3. 1 hit.
InterProⁱ	View protein in InterPro IPR033966. RuBisCO. IPR017712. RuBisCO_III. IPR020878. RuBisCo_large_chain_AS. IPR000685. RuBisCO_lsu_C. IPR017443. RuBisCO_lsu_fd_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00016. RuBisCO_large. 1 hit. PF02788. RuBisCO_large_N. 1 hit.
SFLDⁱ	SFLDS00014. RuBisCO. 1 hit.
SUPFAMⁱ	SSF51649. SSF51649. 1 hit. SSF54966. SSF54966. 1 hit.
TIGRFAMsⁱ	TIGR03326. rubisco_III. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00157. RUBISCO_LARGE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

I7LNH2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAIDWYEEFV DTDHTPGSDE LVALYYFEPA AGISREEAVG RIASESSTGT 
        60         70         80         90        100
WTTLFTMPPR MRDLQAKAFE IEGNYVKIAY PLALWEEGNA PQLLSGIAGN 
       110        120        130        140        150
VFGMKALESL RLIDASLPAE YLRHFKGPHF GMEGIRDMMK VHGRPLTGAV 
       160        170        180        190        200
PKPKVGFTAE EHAEVGYETW MGGFDFVKDD ENLTSLAFNR FEDRVRAMTK 
       210        220        230        240        250
MRDRAEQETG DVKSAFINIT ADTETMKKRA EMLADYGWNY AMIDVVVTGT 
       260        270        280        290        300
AAVATLRDHC SDLGLAIHAH RAMHAAFDRD EKHGITMQFL AKIMRLIGVA 
       310        320        330        340        350
QIHTGTAVGK LVGTKAEATV LADMVREKHT NAVDHMALDQ DWGAIKSAFP 
       360        370        380        390        400
VSSGGLHPGL VPDVLDIYGS DLVLLVSGGI HGHPKGTRAG AMATMQAIEA 
       410        420        430
WSEGETLEEK AKKAPELREA LEKWGYYKPK

Length:430

Mass (Da):47,333

Last modified:October 3, 2012 - v1

Checksum:ⁱ045609878AD9C7AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HE964772 Genomic DNA. Translation: CCJ37089.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_014868062.1. NC_018227.2.

Genome annotation databases

EnsemblBacteriaⁱ	CCJ37089; CCJ37089; BN140_2166.
GeneIDⁱ	13354056.
KEGGⁱ	mbg:BN140_2166.
PATRICⁱ	fig\|1201294.9.peg.2402.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HE964772 Genomic DNA. Translation: CCJ37089.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_014868062.1. NC_018227.2.

3D structure databases

ProteinModelPortalⁱ	I7LNH2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CCJ37089; CCJ37089; BN140_2166.
GeneIDⁱ	13354056.
KEGGⁱ	mbg:BN140_2166.
PATRICⁱ	fig\|1201294.9.peg.2402.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01601.
OMAⁱ	HRAMHAA.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z02MJ.

Enzyme and pathway databases

BioCycⁱ	MBOU1201294:GLGD-2167-MONOMER.

BioCycⁱ

MBOU1201294:GLGD-2167-MONOMER.

Family and domain databases

Gene3Dⁱ	3.20.20.110. 1 hit. 3.30.70.150. 1 hit.
HAMAPⁱ	MF_01133. RuBisCO_L_type3. 1 hit.
InterProⁱ	View protein in InterPro IPR033966. RuBisCO. IPR017712. RuBisCO_III. IPR020878. RuBisCo_large_chain_AS. IPR000685. RuBisCO_lsu_C. IPR017443. RuBisCO_lsu_fd_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00016. RuBisCO_large. 1 hit. PF02788. RuBisCO_large_N. 1 hit.
SFLDⁱ	SFLDS00014. RuBisCO. 1 hit.
SUPFAMⁱ	SSF51649. SSF51649. 1 hit. SSF54966. SSF54966. 1 hit.
TIGRFAMsⁱ	TIGR03326. rubisco_III. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00157. RUBISCO_LARGE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I7LNH2_METBM
Accessionⁱ	I7LNH2Primary (citable) accession number: I7LNH2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 3, 2012
	Last sequence update:	October 3, 2012
	Last modified:	June 7, 2017
	This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - I7LNH2 (I7LNH2_METBM)

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Ribulose bisphosphate carboxylase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ