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I7LLJ8

- I7LLJ8_METBM

UniProt

I7LLJ8 - I7LLJ8_METBM

Protein

DNA ligase

Gene

lig1

Organism
Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei244 – 2441ATPUniRule annotation
    Active sitei246 – 2461N6-AMP-lysine intermediateUniRule annotation
    Binding sitei251 – 2511ATPUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei295 – 2951ATPUniRule annotation
    Binding sitei334 – 3341ATPUniRule annotation
    Binding sitei405 – 4051ATPUniRule annotation
    Binding sitei411 – 4111ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBOU1201294:GLGD-538-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:lig1Imported
    Synonyms:ligUniRule annotation
    Ordered Locus Names:BN140_0526Imported
    OrganismiMethanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)Imported
    Taxonomic identifieri1201294 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
    ProteomesiUP000009007: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I7LLJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFLEFARIC EHLEGISGRL DMIEQVSAVL PGLEDEELPI FVRFIMGRVF    50
    PDWSPKKLGV GPNLLYDAVA YVVGTKRSAV REAINATGDA GLAIEDLLAT 100
    KEQTSFFVQE MDLLEVYWDF ERVAAAEGAR SQREKLLVVR KLFANARPLE 150
    GRYLARLMLE ELRIGMGEGS VRDAVARAFD IDVRLVEHAH QAMNDLGEVA 200
    LLARRDPAAL SRVTIEPFRP VKMMLAQAGT IAGQIEDHGE VAVEYKYDGS 250
    RFQFHKVGNI CRIYSRRLEE VTGSLPDIVM HLGEATDHDV ILDGEVVAVQ 300
    DGRPMPFQYV IRRFRRKHQV NAMMEKIEVV PRVFDILYLD GETLMDRPLA 350
    ERRRILEEVL DAHIAPQFLV TDVAGAEAIY TEALNLGHEG VMVKVPSSPY 400
    TPGVRGRLWV KVKPGVETLD LAVIGAEWGE GRRAKMFGSF LLAVQDQGRL 450
    LPVGKVATGI TDEVLADLYA LLKDSVIARS GKEVTLEPKV VFEVGYSEIQ 500
    ASPNYASGYA LRFPRFVQVR EDKSVDEVET LDALAERYGE QKNGQGSL 548
    Length:548
    Mass (Da):61,152
    Last modified:October 3, 2012 - v1
    Checksum:iCEA0573FE66125EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE964772 Genomic DNA. Translation: CCJ35449.1.
    RefSeqiYP_006544165.1. NC_018227.2.

    Genome annotation databases

    EnsemblBacteriaiCCJ35449; CCJ35449; BN140_0526.
    GeneIDi13354133.
    KEGGimbg:BN140_0526.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE964772 Genomic DNA. Translation: CCJ35449.1 .
    RefSeqi YP_006544165.1. NC_018227.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCJ35449 ; CCJ35449 ; BN140_0526 .
    GeneIDi 13354133.
    KEGGi mbg:BN140_0526.

    Phylogenomic databases

    KOi K10747.

    Enzyme and pathway databases

    BioCyci MBOU1201294:GLGD-538-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hydrogenotrophic, methanogenic archaeon Methanoculleus bourgensis strain MS2T, isolated from a sewage sludge digester."
      Maus I., Wibberg D., Stantscheff R., Eikmeyer F.G., Seffner A., Boelter J., Szczepanowski R., Blom J., Jaenicke S., Konig H., Puhler A., Schluter A.
      J. Bacteriol. 194:5487-5488(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43281 / DSM 3045 / OCM 15 / MS2Imported.

    Entry informationi

    Entry nameiI7LLJ8_METBM
    AccessioniPrimary (citable) accession number: I7LLJ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3