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Protein

DNA ligase

Gene

lig1

Organism
Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1
Active sitei246N6-AMP-lysine intermediateUniRule annotation1
Binding sitei251ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei334ATPUniRule annotation1
Binding sitei405ATPUniRule annotation1
Binding sitei411ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOU1201294:G1HBB-524-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:lig1Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:BN140_0526Imported
OrganismiMethanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)Imported
Taxonomic identifieri1201294 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000009007 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini322 – 446DNA_LIGASE_A3InterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

I7LLJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFLEFARIC EHLEGISGRL DMIEQVSAVL PGLEDEELPI FVRFIMGRVF
60 70 80 90 100
PDWSPKKLGV GPNLLYDAVA YVVGTKRSAV REAINATGDA GLAIEDLLAT
110 120 130 140 150
KEQTSFFVQE MDLLEVYWDF ERVAAAEGAR SQREKLLVVR KLFANARPLE
160 170 180 190 200
GRYLARLMLE ELRIGMGEGS VRDAVARAFD IDVRLVEHAH QAMNDLGEVA
210 220 230 240 250
LLARRDPAAL SRVTIEPFRP VKMMLAQAGT IAGQIEDHGE VAVEYKYDGS
260 270 280 290 300
RFQFHKVGNI CRIYSRRLEE VTGSLPDIVM HLGEATDHDV ILDGEVVAVQ
310 320 330 340 350
DGRPMPFQYV IRRFRRKHQV NAMMEKIEVV PRVFDILYLD GETLMDRPLA
360 370 380 390 400
ERRRILEEVL DAHIAPQFLV TDVAGAEAIY TEALNLGHEG VMVKVPSSPY
410 420 430 440 450
TPGVRGRLWV KVKPGVETLD LAVIGAEWGE GRRAKMFGSF LLAVQDQGRL
460 470 480 490 500
LPVGKVATGI TDEVLADLYA LLKDSVIARS GKEVTLEPKV VFEVGYSEIQ
510 520 530 540
ASPNYASGYA LRFPRFVQVR EDKSVDEVET LDALAERYGE QKNGQGSL
Length:548
Mass (Da):61,152
Last modified:October 3, 2012 - v1
Checksum:iCEA0573FE66125EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE964772 Genomic DNA Translation: CCJ35449.1
RefSeqiWP_014866426.1, NC_018227.2

Genome annotation databases

EnsemblBacteriaiCCJ35449; CCJ35449; BN140_0526
GeneIDi13354133
KEGGimbg:BN140_0526
PATRICifig|1201294.9.peg.565

Similar proteinsi

Entry informationi

Entry nameiI7LLJ8_METBM
AccessioniPrimary (citable) accession number: I7LLJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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