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I7LLJ8

- I7LLJ8_METBM

UniProt

I7LLJ8 - I7LLJ8_METBM

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Protein

DNA ligase

Gene
lig1, lig, BN140_0526
Organism
Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATP By similarityUniRule annotation
Active sitei246 – 2461N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei251 – 2511ATP By similarityUniRule annotation
Binding sitei266 – 2661ATP By similarityUniRule annotation
Binding sitei295 – 2951ATP By similarityUniRule annotation
Binding sitei334 – 3341ATP By similarityUniRule annotation
Binding sitei405 – 4051ATP By similarityUniRule annotation
Binding sitei411 – 4111ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOU1201294:GLGD-538-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig1Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:BN140_0526Imported
OrganismiMethanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)Imported
Taxonomic identifieri1201294 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
ProteomesiUP000009007: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I7LLJ8-1 [UniParc]FASTAAdd to Basket

« Hide

MQFLEFARIC EHLEGISGRL DMIEQVSAVL PGLEDEELPI FVRFIMGRVF    50
PDWSPKKLGV GPNLLYDAVA YVVGTKRSAV REAINATGDA GLAIEDLLAT 100
KEQTSFFVQE MDLLEVYWDF ERVAAAEGAR SQREKLLVVR KLFANARPLE 150
GRYLARLMLE ELRIGMGEGS VRDAVARAFD IDVRLVEHAH QAMNDLGEVA 200
LLARRDPAAL SRVTIEPFRP VKMMLAQAGT IAGQIEDHGE VAVEYKYDGS 250
RFQFHKVGNI CRIYSRRLEE VTGSLPDIVM HLGEATDHDV ILDGEVVAVQ 300
DGRPMPFQYV IRRFRRKHQV NAMMEKIEVV PRVFDILYLD GETLMDRPLA 350
ERRRILEEVL DAHIAPQFLV TDVAGAEAIY TEALNLGHEG VMVKVPSSPY 400
TPGVRGRLWV KVKPGVETLD LAVIGAEWGE GRRAKMFGSF LLAVQDQGRL 450
LPVGKVATGI TDEVLADLYA LLKDSVIARS GKEVTLEPKV VFEVGYSEIQ 500
ASPNYASGYA LRFPRFVQVR EDKSVDEVET LDALAERYGE QKNGQGSL 548
Length:548
Mass (Da):61,152
Last modified:October 3, 2012 - v1
Checksum:iCEA0573FE66125EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE964772 Genomic DNA. Translation: CCJ35449.1.
RefSeqiYP_006544165.1. NC_018227.2.

Genome annotation databases

EnsemblBacteriaiCCJ35449; CCJ35449; BN140_0526.
GeneIDi13354133.
KEGGimbg:BN140_0526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE964772 Genomic DNA. Translation: CCJ35449.1 .
RefSeqi YP_006544165.1. NC_018227.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCJ35449 ; CCJ35449 ; BN140_0526 .
GeneIDi 13354133.
KEGGi mbg:BN140_0526.

Phylogenomic databases

KOi K10747.

Enzyme and pathway databases

BioCyci MBOU1201294:GLGD-538-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hydrogenotrophic, methanogenic archaeon Methanoculleus bourgensis strain MS2T, isolated from a sewage sludge digester."
    Maus I., Wibberg D., Stantscheff R., Eikmeyer F.G., Seffner A., Boelter J., Szczepanowski R., Blom J., Jaenicke S., Konig H., Puhler A., Schluter A.
    J. Bacteriol. 194:5487-5488(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43281 / DSM 3045 / OCM 15 / MS2.

Entry informationi

Entry nameiI7LLJ8_METBM
AccessioniPrimary (citable) accession number: I7LLJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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