ID   I7JHQ8_HUMAN            Unreviewed;       298 AA.
AC   I7JHQ8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   03-MAY-2023, entry version 37.
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CCK33656.1};
DE   Flags: Fragment;
GN   Name=HLA-B {ECO:0000313|EMBL:CCK33656.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CCK33656.1};
RN   [1] {ECO:0000313|EMBL:CCK33656.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:CCK33656.1};
RA   Froelich N., Schell A., Weschler B., Leisenbach R., Mariotte A., Bert S.,
RA   Hanau D., Tourne S.;
RT   "The new HLA-B*08 allele has a nucleotide change from HLA-B*49:01:01 (a G
RT   to A ) at position 36 (exon 1), which is silent.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; HE974341; CCK33656.1; -; Genomic_DNA.
DR   AlphaFoldDB; I7JHQ8; -.
DR   ChiTaRS; HLA-B; human.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF270; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..298
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003710889"
FT   DOMAIN          209..295
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         298
FT                   /evidence="ECO:0000313|EMBL:CCK33656.1"
SQ   SEQUENCE   298 AA;  34227 MW;  3A62E94E246130C7 CRC64;
     MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFDTAMSRPG RGEPRFISVG YVDDTQFVRF
     DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTDRE SLRNLRGYYN QSEAGSHTLQ
     SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD
     RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRW
//