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I7J7N3

- I7J7N3_METBM

UniProt

I7J7N3 - I7J7N3_METBM

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Protein
DNA ligase
Gene
lig3, lig, BN140_0625
Organism
Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491ATP By similarityUniRule annotation
Active sitei251 – 2511N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei256 – 2561ATP By similarityUniRule annotation
Binding sitei271 – 2711ATP By similarityUniRule annotation
Binding sitei301 – 3011ATP By similarityUniRule annotation
Binding sitei341 – 3411ATP By similarityUniRule annotation
Binding sitei418 – 4181ATP By similarityUniRule annotation
Binding sitei424 – 4241ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOU1201294:GLGD-645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig3Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:BN140_0625Imported
OrganismiMethanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)Imported
Taxonomic identifieri1201294 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
ProteomesiUP000009007: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I7J7N3-1 [UniParc]FASTAAdd to Basket

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MKFATLASCF ERLNVTSSRN DMTALLARLL AGASPDEIGI VCYFTLGAIA    50
PGYSGLTPGI GERTAAAAIA LAGSVDPAAV EAAARELGDY GDAAARLTVA 100
PPEGSTGPLR VTDVHRGFME IARASGPGSA DRKTRVLAAM LAAATPPERR 150
YLVRLATGEM RLGVGDMTLL DALAEAFLGS KAERPPLEHA YNISSDVGLV 200
ARTLQESGLA GVSAIPVTLH HPIRPMLTQR VSRISEIPER IGSRVIAVEE 250
KYDGERVQAH KDGDDVTLFS RRLTDVTHQY PDIVRHIRRC VTADTAILDG 300
EAVAFDHETG TYRPFQTLMR RRRKHRVREV AGEIPATYRV FDLLYVNGES 350
YLRRSYPDRR ARLEEVLSPD EKISPADRTL TGDLDGITEF YLACIERGLE 400
GVVCKSCAED SFYRAGAREW QWIKWKSDYG TELADTLDLV VVGANAGRGK 450
RAGTYGSVLC AAYNHEEDIF QTVCGMGTGF TDADLADLPR RFAGVRVDRQ 500
PARVMVTPQA VPDFWFAPAR VVEVLGLEIT ESPVHTCNWD PEWRRGLALR 550
FPRFVRWRDE KSPEAATTTA EVAAMFRRRR EG 582
Length:582
Mass (Da):63,967
Last modified:October 3, 2012 - v1
Checksum:i00CDF4CBE0E0262C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE964772 Genomic DNA. Translation: CCJ35548.1.
RefSeqiWP_014866525.1. NC_018227.2.
YP_006544264.1. NC_018227.2.

Genome annotation databases

EnsemblBacteriaiCCJ35548; CCJ35548; BN140_0625.
GeneIDi13354285.
KEGGimbg:BN140_0625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE964772 Genomic DNA. Translation: CCJ35548.1 .
RefSeqi WP_014866525.1. NC_018227.2.
YP_006544264.1. NC_018227.2.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCJ35548 ; CCJ35548 ; BN140_0625 .
GeneIDi 13354285.
KEGGi mbg:BN140_0625.

Phylogenomic databases

KOi K10747.

Enzyme and pathway databases

BioCyci MBOU1201294:GLGD-645-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hydrogenotrophic, methanogenic archaeon Methanoculleus bourgensis strain MS2T, isolated from a sewage sludge digester."
    Maus I., Wibberg D., Stantscheff R., Eikmeyer F.G., Seffner A., Boelter J., Szczepanowski R., Blom J., Jaenicke S., Konig H., Puhler A., Schluter A.
    J. Bacteriol. 194:5487-5488(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43281 / DSM 3045 / OCM 15 / MS2.

Entry informationi

Entry nameiI7J7N3_METBM
AccessioniPrimary (citable) accession number: I7J7N3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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