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I7J7N3 (I7J7N3_METBM) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2511N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2491ATP By similarity HAMAP-Rule MF_00407
Binding site2561ATP By similarity HAMAP-Rule MF_00407
Binding site2711ATP By similarity HAMAP-Rule MF_00407
Binding site3011ATP By similarity HAMAP-Rule MF_00407
Binding site3411ATP By similarity HAMAP-Rule MF_00407
Binding site4181ATP By similarity HAMAP-Rule MF_00407
Binding site4241ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
I7J7N3 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: 00CDF4CBE0E0262C

FASTA58263,967
        10         20         30         40         50         60 
MKFATLASCF ERLNVTSSRN DMTALLARLL AGASPDEIGI VCYFTLGAIA PGYSGLTPGI 

        70         80         90        100        110        120 
GERTAAAAIA LAGSVDPAAV EAAARELGDY GDAAARLTVA PPEGSTGPLR VTDVHRGFME 

       130        140        150        160        170        180 
IARASGPGSA DRKTRVLAAM LAAATPPERR YLVRLATGEM RLGVGDMTLL DALAEAFLGS 

       190        200        210        220        230        240 
KAERPPLEHA YNISSDVGLV ARTLQESGLA GVSAIPVTLH HPIRPMLTQR VSRISEIPER 

       250        260        270        280        290        300 
IGSRVIAVEE KYDGERVQAH KDGDDVTLFS RRLTDVTHQY PDIVRHIRRC VTADTAILDG 

       310        320        330        340        350        360 
EAVAFDHETG TYRPFQTLMR RRRKHRVREV AGEIPATYRV FDLLYVNGES YLRRSYPDRR 

       370        380        390        400        410        420 
ARLEEVLSPD EKISPADRTL TGDLDGITEF YLACIERGLE GVVCKSCAED SFYRAGAREW 

       430        440        450        460        470        480 
QWIKWKSDYG TELADTLDLV VVGANAGRGK RAGTYGSVLC AAYNHEEDIF QTVCGMGTGF 

       490        500        510        520        530        540 
TDADLADLPR RFAGVRVDRQ PARVMVTPQA VPDFWFAPAR VVEVLGLEIT ESPVHTCNWD 

       550        560        570        580 
PEWRRGLALR FPRFVRWRDE KSPEAATTTA EVAAMFRRRR EG 

« Hide

References

[1]"Complete genome sequence of the hydrogenotrophic, methanogenic archaeon Methanoculleus bourgensis strain MS2T, isolated from a sewage sludge digester."
Maus I., Wibberg D., Stantscheff R., Eikmeyer F.G., Seffner A., Boelter J., Szczepanowski R., Blom J., Jaenicke S., Konig H., Puhler A., Schluter A.
J. Bacteriol. 194:5487-5488(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43281 / DSM 3045 / OCM 15 / MS2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE964772 Genomic DNA. Translation: CCJ35548.1.
RefSeqYP_006544264.1. NC_018227.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCJ35548; CCJ35548; BN140_0625.
GeneID13354285.
KEGGmbg:BN140_0625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.

Enzyme and pathway databases

BioCycMBOU1201294:GLGD-645-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI7J7N3_METBM
AccessionPrimary (citable) accession number: I7J7N3
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)