ID   I7HFK0_HUMAN            Unreviewed;       273 AA.
AC   I7HFK0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:BAM34487.1};
DE   Flags: Fragment;
GN   Name=HLA-B {ECO:0000313|EMBL:BAM34487.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAM34487.1};
RN   [1] {ECO:0000313|EMBL:BAM34487.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Shimizu M., Nakajima F., Tadokoro K.;
RT   "HLA-JMDP-B-035.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; AB738079; BAM34487.1; -; Genomic_DNA.
DR   AlphaFoldDB; I7HFK0; -.
DR   PeptideAtlas; I7HFK0; -.
DR   ChiTaRS; HLA-B; human.
DR   GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022451};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   MHC I {ECO:0000256|ARBA:ARBA00022451};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          184..270
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAM34487.1"
FT   NON_TER         273
FT                   /evidence="ECO:0000313|EMBL:BAM34487.1"
SQ   SEQUENCE   273 AA;  31740 MW;  AF4B6550FBFCF8BA CRC64;
     SHSMRYFYTA MSRPGRGEPR FIAVGYVDDT QFVRFDSDAA SPRTEPRAPW IEQEGPEYWD
     RNTQIFKTNT QTYRENLRIA LRYYNQSEAG SHTWQTMYGC DVGPDGRLLR GHNQYAYDGK
     DYIALNEDLS SWTAADTAAQ ITQRKWEAAR EAEQLRAYLE GTCVEWLRRY LENGKETLQR
     ADPPKTHVTH HPVSDHEATL RCWALGFYPA EITLTWQRDG EDQTQDTELV ETRPAGDRTF
     QKWAAVVVPS GEEQRYTCHV QHEGLPKPLT LRW
//