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I7GRB0

- I7GRB0_CORUL

UniProt

I7GRB0 - I7GRB0_CORUL

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Corynebacterium ulcerans 0102
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei252 – 2521Critical for catalysisUniRule annotation
    Metal bindingi345 – 3451Magnesium or manganese
    Sitei415 – 4151Critical for catalysisUniRule annotation
    Binding sitei542 – 5421SubstrateUniRule annotation
    Metal bindingi543 – 5431Magnesium or manganese
    Metal bindingi547 – 5471Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciCULC996634:GLC3-631-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported
    Gene namesi
    Name:icdImported
    ORF Names:CULC0102_0613Imported
    OrganismiCorynebacterium ulcerans 0102Imported
    Taxonomic identifieri996634 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002821: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I7GRB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILSQF    50
    PEFLAEDQKV DDALAELGDL AKTPEANIIK LPNISASVPQ LKAAVAELQS 100
    QGYKLPDYPD SPSTDEEKDI RARYDAVKGS AVNPVLREGN SDRRAPIAVK 150
    NFAKKHPHRM GAWSADSKTN VVTMESDDFR HNEKSVIMPS DDTLTIKLVT 200
    DNGEKVLKEG LKVLKGEVVD GTFISARALD EFLAVQVKRA KDEGVLFSAH 250
    LKATMMKVSD PIIFGYVVRA YFADVFATYG EQLEAAGLNG ENGLAAIYSG 300
    LESLPNGAEI KAAFDAALES GADIAMVNSA KGITNLHVPS DVIIDASMPA 350
    MIRTSGHMWN KNDEEQDTLA VIPDSSYAGV YQTVITDCKK NGAFDPTTMG 400
    TVPNVGLMAQ KAEEYGSHDK TFKIEANGTV QVVNSAGEVL IEHNVEAGDI 450
    WRACQAKDAP IQDWVKLAVT RSRLSGMPAV FWLDPERAHD RNLTTLVEKY 500
    LADHDTEGLD IRIMSPVDAT QFSIDRIRRG EDTISVTGNV LRDYNTDLFP 550
    ILELGTSAKM LSVVPLMAGG GLFETGAGGS APKHVQQLVE ENHLRWDSLG 600
    EFLALAESLR HFANTEGNTK AGVLADALDR ATETLLNEGY SPSRKAGEID 650
    NRGSHFFLTK FWAKELSIQS EDADLAATFA PVAEALEAHS DEIADALLAV 700
    QGTPADLGGY YQPDDAKTTA IMRPVASYNN IISSIK 736
    Length:736
    Mass (Da):79,694
    Last modified:October 3, 2012 - v1
    Checksum:iA105E02F810A83A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012284 Genomic DNA. Translation: BAM26814.1.
    RefSeqiYP_006494049.1. NC_018101.1.

    Genome annotation databases

    EnsemblBacteriaiBAM26814; BAM26814; CULC0102_0613.
    GeneIDi13303032.
    KEGGicue:CULC0102_0613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012284 Genomic DNA. Translation: BAM26814.1 .
    RefSeqi YP_006494049.1. NC_018101.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAM26814 ; BAM26814 ; CULC0102_0613 .
    GeneIDi 13303032.
    KEGGi cue:CULC0102_0613.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci CULC996634:GLC3-631-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage."
      Sekizuka T., Yamamoto A., Komiya T., Kenri T., Takeuchi F., Shibayama K., Takahashi M., Kuroda M., Iwaki M.
      BMC Microbiol. 12:72-72(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 0102Imported.

    Entry informationi

    Entry nameiI7GRB0_CORUL
    AccessioniPrimary (citable) accession number: I7GRB0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3