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I7GRB0

- I7GRB0_CORUL

UniProt

I7GRB0 - I7GRB0_CORUL

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Protein
Submitted name: Isocitrate dehydrogenase
Gene
icd, CULC0102_0613
Organism
Corynebacterium ulcerans 0102
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Sitei252 – 2521Critical for catalysis By similarityUniRule annotation
Metal bindingi345 – 3451Magnesium or manganese By similarityUniRule annotation
Sitei415 – 4151Critical for catalysis By similarity
Binding sitei542 – 5421Substrate By similarityUniRule annotation
Metal bindingi543 – 5431Magnesium or manganese By similarityUniRule annotation
Metal bindingi547 – 5471Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCULC996634:GLC3-631-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Name:icdImported
ORF Names:CULC0102_0613Imported
OrganismiCorynebacterium ulcerans 0102Imported
Taxonomic identifieri996634 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002821: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

I7GRB0-1 [UniParc]FASTAAdd to Basket

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MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILSQF    50
PEFLAEDQKV DDALAELGDL AKTPEANIIK LPNISASVPQ LKAAVAELQS 100
QGYKLPDYPD SPSTDEEKDI RARYDAVKGS AVNPVLREGN SDRRAPIAVK 150
NFAKKHPHRM GAWSADSKTN VVTMESDDFR HNEKSVIMPS DDTLTIKLVT 200
DNGEKVLKEG LKVLKGEVVD GTFISARALD EFLAVQVKRA KDEGVLFSAH 250
LKATMMKVSD PIIFGYVVRA YFADVFATYG EQLEAAGLNG ENGLAAIYSG 300
LESLPNGAEI KAAFDAALES GADIAMVNSA KGITNLHVPS DVIIDASMPA 350
MIRTSGHMWN KNDEEQDTLA VIPDSSYAGV YQTVITDCKK NGAFDPTTMG 400
TVPNVGLMAQ KAEEYGSHDK TFKIEANGTV QVVNSAGEVL IEHNVEAGDI 450
WRACQAKDAP IQDWVKLAVT RSRLSGMPAV FWLDPERAHD RNLTTLVEKY 500
LADHDTEGLD IRIMSPVDAT QFSIDRIRRG EDTISVTGNV LRDYNTDLFP 550
ILELGTSAKM LSVVPLMAGG GLFETGAGGS APKHVQQLVE ENHLRWDSLG 600
EFLALAESLR HFANTEGNTK AGVLADALDR ATETLLNEGY SPSRKAGEID 650
NRGSHFFLTK FWAKELSIQS EDADLAATFA PVAEALEAHS DEIADALLAV 700
QGTPADLGGY YQPDDAKTTA IMRPVASYNN IISSIK 736
Length:736
Mass (Da):79,694
Last modified:October 3, 2012 - v1
Checksum:iA105E02F810A83A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012284 Genomic DNA. Translation: BAM26814.1.
RefSeqiYP_006494049.1. NC_018101.1.

Genome annotation databases

EnsemblBacteriaiBAM26814; BAM26814; CULC0102_0613.
GeneIDi13303032.
KEGGicue:CULC0102_0613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012284 Genomic DNA. Translation: BAM26814.1 .
RefSeqi YP_006494049.1. NC_018101.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM26814 ; BAM26814 ; CULC0102_0613 .
GeneIDi 13303032.
KEGGi cue:CULC0102_0613.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci CULC996634:GLC3-631-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage."
    Sekizuka T., Yamamoto A., Komiya T., Kenri T., Takeuchi F., Shibayama K., Takahashi M., Kuroda M., Iwaki M.
    BMC Microbiol. 12:72-72(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 0102Imported.

Entry informationi

Entry nameiI7GRB0_CORUL
AccessioniPrimary (citable) accession number: I7GRB0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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