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I7GRB0

- I7GRB0_CORUL

UniProt

I7GRB0 - I7GRB0_CORUL

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Corynebacterium ulcerans 0102
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei252 – 2521Critical for catalysisUniRule annotation
Metal bindingi345 – 3451Magnesium or manganese
Sitei415 – 4151Critical for catalysisUniRule annotation
Binding sitei542 – 5421SubstrateUniRule annotation
Metal bindingi543 – 5431Magnesium or manganese
Metal bindingi547 – 5471Magnesium or manganese

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCULC996634:GLC3-631-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Name:icdImported
ORF Names:CULC0102_0613Imported
OrganismiCorynebacterium ulcerans 0102Imported
Taxonomic identifieri996634 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002821: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

I7GRB0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILSQF
60 70 80 90 100
PEFLAEDQKV DDALAELGDL AKTPEANIIK LPNISASVPQ LKAAVAELQS
110 120 130 140 150
QGYKLPDYPD SPSTDEEKDI RARYDAVKGS AVNPVLREGN SDRRAPIAVK
160 170 180 190 200
NFAKKHPHRM GAWSADSKTN VVTMESDDFR HNEKSVIMPS DDTLTIKLVT
210 220 230 240 250
DNGEKVLKEG LKVLKGEVVD GTFISARALD EFLAVQVKRA KDEGVLFSAH
260 270 280 290 300
LKATMMKVSD PIIFGYVVRA YFADVFATYG EQLEAAGLNG ENGLAAIYSG
310 320 330 340 350
LESLPNGAEI KAAFDAALES GADIAMVNSA KGITNLHVPS DVIIDASMPA
360 370 380 390 400
MIRTSGHMWN KNDEEQDTLA VIPDSSYAGV YQTVITDCKK NGAFDPTTMG
410 420 430 440 450
TVPNVGLMAQ KAEEYGSHDK TFKIEANGTV QVVNSAGEVL IEHNVEAGDI
460 470 480 490 500
WRACQAKDAP IQDWVKLAVT RSRLSGMPAV FWLDPERAHD RNLTTLVEKY
510 520 530 540 550
LADHDTEGLD IRIMSPVDAT QFSIDRIRRG EDTISVTGNV LRDYNTDLFP
560 570 580 590 600
ILELGTSAKM LSVVPLMAGG GLFETGAGGS APKHVQQLVE ENHLRWDSLG
610 620 630 640 650
EFLALAESLR HFANTEGNTK AGVLADALDR ATETLLNEGY SPSRKAGEID
660 670 680 690 700
NRGSHFFLTK FWAKELSIQS EDADLAATFA PVAEALEAHS DEIADALLAV
710 720 730
QGTPADLGGY YQPDDAKTTA IMRPVASYNN IISSIK
Length:736
Mass (Da):79,694
Last modified:October 3, 2012 - v1
Checksum:iA105E02F810A83A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012284 Genomic DNA. Translation: BAM26814.1.
RefSeqiYP_006494049.1. NC_018101.1.

Genome annotation databases

EnsemblBacteriaiBAM26814; BAM26814; CULC0102_0613.
GeneIDi13303032.
KEGGicue:CULC0102_0613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012284 Genomic DNA. Translation: BAM26814.1 .
RefSeqi YP_006494049.1. NC_018101.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM26814 ; BAM26814 ; CULC0102_0613 .
GeneIDi 13303032.
KEGGi cue:CULC0102_0613.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci CULC996634:GLC3-631-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage."
    Sekizuka T., Yamamoto A., Komiya T., Kenri T., Takeuchi F., Shibayama K., Takahashi M., Kuroda M., Iwaki M.
    BMC Microbiol. 12:72-72(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 0102Imported.

Entry informationi

Entry nameiI7GRB0_CORUL
AccessioniPrimary (citable) accession number: I7GRB0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3