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Protein
Submitted name:

Cytochrome P450 CYP125

Gene

cyp125

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi368 – 3681Iron (heme axial ligand)Combined sources

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: InterPro
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

HemeCombined sources, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 CYP125Imported (EC:1.14.13.151Imported)
Gene namesi
Name:cyp125Imported
Ordered Locus Names:MSMEI_5834Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006158: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4APYX-ray2.00A9-435[»]
ProteinModelPortaliI7G9K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

I7G9K1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MHFEERTPMP TPNIPSDFDF LDATLNLERL PVEELAELRK SEPIHWVDVP
60 70 80 90 100
GGTGGFGDKG YWLVTKHADV KEVSRRSDVF GSSPDGAIPV WPQDMTREAV
110 120 130 140 150
DLQRAVLLNM DAPQHTRLRK IISRGFTPRA IGRLEDELRS RAQKIAQTAA
160 170 180 190 200
AQGAGDFVEQ VSCELPLQAI AELLGVPQDD RDKLFRWSNE MTAGEDPEYA
210 220 230 240 250
DVDPAMSSFE LISYAMKMAE ERAVNPTEDI VTKLIEADID GEKLSDDEFG
260 270 280 290 300
FFVVMLAVAG NETTRNSITH GMIAFAQNPD QWELYKKERP ETAADEIVRW
310 320 330 340 350
ATPVSAFQRT ALEDVELGGV QIKKGQRVVM SYRSANFDEE VFEDPHTFNI
360 370 380 390 400
LRSPNPHVGF GGTGAHYCIG ANLARMTINL IFNAIADNMP DLKPIGAPER
410 420 430
LKSGWLNGIK HWQVDYTGAG KASVSGAPGT CPVAH
Length:435
Mass (Da):48,134
Last modified:October 3, 2012 - v1
Checksum:i1933780D38272514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001663 Genomic DNA. Translation: AFP42267.1.
RefSeqiWP_014878520.1. NC_018289.1.
YP_006570562.1. NC_018289.1.

Genome annotation databases

EnsemblBacteriaiAFP42267; AFP42267; MSMEI_5834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001663 Genomic DNA. Translation: AFP42267.1.
RefSeqiWP_014878520.1. NC_018289.1.
YP_006570562.1. NC_018289.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4APYX-ray2.00A9-435[»]
ProteinModelPortaliI7G9K1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFP42267; AFP42267; MSMEI_5834.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported.
  2. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "A highly conserved mycobacterial cholesterol catabolic pathway."
    Garcia-Fernandez E., Frank D.J., Galan B., Kells P.M., Podust L.M., Garcia J.L., Ortiz de Montellano P.R.
    Environ. Microbiol. 15:2342-2359(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 9-435 IN COMPLEX WITH HEME.

Entry informationi

Entry nameiI7G9K1_MYCS2
AccessioniPrimary (citable) accession number: I7G9K1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: January 7, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.