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I7G9K1

- I7G9K1_MYCS2

UniProt

I7G9K1 - I7G9K1_MYCS2

Protein
Submitted name:

Cytochrome P450 CYP125

Gene

cyp125

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi368 – 3681Iron (heme axial ligand)Imported

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: InterPro
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    HemeImported, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cytochrome P450 CYP125Imported (EC:1.14.13.151Imported)
    Gene namesi
    Name:cyp125Imported
    Ordered Locus Names:MSMEI_5834Imported
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006158: Chromosome

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4APYX-ray2.00A9-435[»]
    ProteinModelPortaliI7G9K1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK15981.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR002397. Cyt_P450_B.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00359. BP450.
    SUPFAMiSSF48264. SSF48264. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I7G9K1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFEERTPMP TPNIPSDFDF LDATLNLERL PVEELAELRK SEPIHWVDVP    50
    GGTGGFGDKG YWLVTKHADV KEVSRRSDVF GSSPDGAIPV WPQDMTREAV 100
    DLQRAVLLNM DAPQHTRLRK IISRGFTPRA IGRLEDELRS RAQKIAQTAA 150
    AQGAGDFVEQ VSCELPLQAI AELLGVPQDD RDKLFRWSNE MTAGEDPEYA 200
    DVDPAMSSFE LISYAMKMAE ERAVNPTEDI VTKLIEADID GEKLSDDEFG 250
    FFVVMLAVAG NETTRNSITH GMIAFAQNPD QWELYKKERP ETAADEIVRW 300
    ATPVSAFQRT ALEDVELGGV QIKKGQRVVM SYRSANFDEE VFEDPHTFNI 350
    LRSPNPHVGF GGTGAHYCIG ANLARMTINL IFNAIADNMP DLKPIGAPER 400
    LKSGWLNGIK HWQVDYTGAG KASVSGAPGT CPVAH 435
    Length:435
    Mass (Da):48,134
    Last modified:October 3, 2012 - v1
    Checksum:i1933780D38272514
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001663 Genomic DNA. Translation: AFP42267.1.
    RefSeqiYP_006570562.1. NC_018289.1.

    Genome annotation databases

    EnsemblBacteriaiAFP42267; AFP42267; MSMEI_5834.
    KEGGimsg:MSMEI_5834.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001663 Genomic DNA. Translation: AFP42267.1 .
    RefSeqi YP_006570562.1. NC_018289.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4APY X-ray 2.00 A 9-435 [» ]
    ProteinModelPortali I7G9K1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFP42267 ; AFP42267 ; MSMEI_5834 .
    KEGGi msg:MSMEI_5834.

    Phylogenomic databases

    KOi K15981.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR002397. Cyt_P450_B.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00359. BP450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155Imported.
    2. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "A highly conserved mycobacterial cholesterol catabolic pathway."
      Garcia-Fernandez E., Frank D.J., Galan B., Kells P.M., Podust L.M., Garcia J.L., Ortiz de Montellano P.R.
      Environ. Microbiol. 15:2342-2359(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 9-435 IN COMPLEX WITH HEME.

    Entry informationi

    Entry nameiI7G9K1_MYCS2
    AccessioniPrimary (citable) accession number: I7G9K1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3