Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Uchl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

  1. alpha-2A adrenergic receptor binding Source: MGI
  2. cysteine-type endopeptidase activity Source: MGI
  3. ligase activity Source: InterPro
  4. omega peptidase activity Source: MGI
  5. ubiquitin binding Source: MGI
  6. ubiquitin-specific protease activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. axonogenesis Source: MGI
  3. axon target recognition Source: MGI
  4. axon transport of mitochondrion Source: MGI
  5. cell proliferation Source: MGI
  6. eating behavior Source: MGI
  7. muscle fiber development Source: MGI
  8. negative regulation of MAP kinase activity Source: MGI
  9. neuromuscular process Source: MGI
  10. protein deubiquitination Source: MGI
  11. response to ischemia Source: MGI
  12. sensory perception of pain Source: Ensembl
  13. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Uchl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103149. Uchl1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: MGI
  4. extracellular vesicular exosome Source: MGI
  5. neuronal cell body Source: MGI
  6. nucleoplasm Source: MGI
  7. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiI7ENE7. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.UniRule annotation

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
IPR030297. UCHL1.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PTHR10589:SF19. PTHR10589:SF19. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiPS00140. UCH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

I7ENE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PEMLNKVLAK LGVAGQWRFA DVLGLEEETL GSVPSPACAL LLLFPLTAQH
60 70 80 90 100
ENFRKKQIEE LKGQEVSPKV YFMKQTIGNS CGTIGLIHAV ANNQDKLEFE
110 120 130 140
DGSVLKQFLS ETEKLSPEDR AKCFEKNEAI QAAHDSVAQE GQCRVDD
Length:147
Mass (Da):16,244
Last modified:October 2, 2012 - v1
Checksum:i39FA401863472E25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei147 – 1471Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX050004 mRNA. Translation: AFP20215.1.
UniGeneiMm.29807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX050004 mRNA. Translation: AFP20215.1.
UniGeneiMm.29807.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiI7ENE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103149. Uchl1.

Miscellaneous databases

ChiTaRSiUchl1. mouse.
NextBioi35562498.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiI7ENE7. baseline and differential.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
IPR030297. UCHL1.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PTHR10589:SF19. PTHR10589:SF19. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiPS00140. UCH_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of Ubiquitin Carboxy Terminal Hydrolase (UCHL-1) Gene in Testes of a Wide Variety of Vertebrates."
    Katakam M., Mallarapu L.D., Pawar R.M., Goel S.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiI7ENE7_MOUSE
AccessioniPrimary (citable) accession number: I7ENE7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2012
Last sequence update: October 2, 2012
Last modified: March 31, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.