ID   I7D962_HUMAN            Unreviewed;        89 AA.
AC   I7D962;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AFO70160.1};
DE   Flags: Fragment;
GN   Name=HLA-DRB1 {ECO:0000313|EMBL:AFO70160.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AFO70160.1};
RN   [1] {ECO:0000313|EMBL:AFO70160.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23489469; DOI=10.1111/tan.12089;
RA   Wowk P.F., Mattar S.B., Bicalho M.G.;
RT   "Identification of a new HLA-DRB1*11 variant, HLA-DRB1*11:130, by sequence-
RT   based typing in a Brazilian individual.";
RL   Tissue Antigens 81:469-470(2013).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JX069944; AFO70160.1; -; Genomic_DNA.
DR   AlphaFoldDB; I7D962; -.
DR   PeptideAtlas; I7D962; -.
DR   ChiTaRS; HLA-DRB1; human.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:InterPro.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   PANTHER; PTHR19944:SF99; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 3 CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          8..82
FT                   /note="MHC class II beta chain N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00921"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFO70160.1"
FT   NON_TER         89
FT                   /evidence="ECO:0000313|EMBL:AFO70160.1"
SQ   SEQUENCE   89 AA;  10898 MW;  00AAC498D34703BA CRC64;
     RFLEYSTSEC HFFNGTERVR FLDRYFYNQE EYVRFDSDVG EFRAVTELGR PDEDYWNSQK
     DLLEDRRAAV DTYCRHNYGV VESFTVQRR
//