ID   I7CV83_NATSJ            Unreviewed;       553 AA.
AC   I7CV83;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:AFO58068.1};
GN   OrderedLocusNames=NJ7G_2839 {ECO:0000313|EMBL:AFO58068.1};
OS   Natrinema sp. (strain J7-2).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrinema.
OX   NCBI_TaxID=406552 {ECO:0000313|EMBL:AFO58068.1, ECO:0000313|Proteomes:UP000006507};
RN   [1] {ECO:0000313|EMBL:AFO58068.1, ECO:0000313|Proteomes:UP000006507}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J7-2 {ECO:0000313|EMBL:AFO58068.1,
RC   ECO:0000313|Proteomes:UP000006507};
RX   PubMed=22911826; DOI=10.1371/journal.pone.0041621;
RA   Feng J., Liu B., Zhang Z., Ren Y., Li Y., Gan F., Huang Y., Chen X.,
RA   Shen P., Wang L., Tang B., Tang X.F.;
RT   "The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable
RT   of growth on synthetic media without amino acid supplements.";
RL   PLoS ONE 7:E41621-E41621(2012).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP003412; AFO58068.1; -; Genomic_DNA.
DR   RefSeq; WP_014864739.1; NC_018224.1.
DR   AlphaFoldDB; I7CV83; -.
DR   STRING; 406552.NJ7G_2839; -.
DR   GeneID; 13349466; -.
DR   KEGG; nat:NJ7G_2839; -.
DR   PATRIC; fig|406552.5.peg.2495; -.
DR   eggNOG; arCOG04201; Archaea.
DR   HOGENOM; CLU_000022_59_10_2; -.
DR   OrthoDB; 193284at2157; -.
DR   Proteomes; UP000006507; Chromosome.
DR   GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR   GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AFO58068.1}.
FT   DOMAIN          41..397
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          460..538
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   553 AA;  61368 MW;  F1A02FF190D7CFAB CRC64;
     MAWTVMPTYD DYETARAAFT WNLPDEYNPA VDFLRKHEDT SRTALRYEAP DDGLETYSFD
     DLDERSDRLA AALADLGVGA GDRVGVVVPQ KPQNPLTHLA NWKLGAVSVP LTVLFGRDAL
     QYRLEDSEAT VAVVDPSVRE TVDEIRAACP ALEHVIELGD GESVRSGAHA FDDLVAAHDP
     GIEHYDSTPE TPTAIMYTSG STGPPKGVRH SHALWLGRAA AAYNYFDQGL RAGESMLWTP
     ADWAWGAALG GTLFAAWHHG CPVIGWPRDG FDPDEVYDLL ERHDVTATFM PPTALRMLMS
     VDDPDARYDL SLETIASAGE PLTSEVVDWV DAAFEDVAIN EFYGQTELNL VVGNAERWFD
     TRPGSMGKPF PGYEIAVLDP ETGERLERGA VGELAVKPGD RRVFFDAYHG LPEKTADKRT
     EEGWFLTGDL VKRDADGYVR FVSRADDVIL TSGYRVGPME VEDAILTHRA VEQTGVVGVP
     DDTRGEAIMA YVKPATDDYD PDELRTEIRT VVRDRLAEYE YPKHIEFVER LPTTTTGKIR
     RRALRERDRT GEE
//