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I7CQ19

- I7CQ19_NATSJ

UniProt

I7CQ19 - I7CQ19_NATSJ

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Natrinema sp. (strain J7-2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei157 – 1571Proton acceptorUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Metal bindingi183 – 1831Magnesium; via carbamate groupUniRule annotation
Metal bindingi185 – 1851MagnesiumUniRule annotation
Metal bindingi186 – 1861MagnesiumUniRule annotation
Active sitei275 – 2751Proton acceptorUniRule annotation
Binding sitei276 – 2761SubstrateUniRule annotation
Binding sitei308 – 3081SubstrateUniRule annotation
Sitei316 – 3161Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciNSP406552:GLHM-827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:NJ7G_0819Imported
OrganismiNatrinema sp. (strain J7-2)Imported
Taxonomic identifieri406552 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatrinema
ProteomesiUP000006507: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI7CQ19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 3463Substrate bindingUniRule annotation
Regioni366 – 3694Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation
Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

I7CQ19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDGIMTGIE YDDFLDLGYE PAGTELVCEF TIEPAAGMSM EAAASRVASE
60 70 80 90 100
SSNGTWAALH VDEDELTDLG AVACGIDGRT VTVAYPTALF EAGSMPQLLS
110 120 130 140 150
CIAGNILGMK AVDSIRLEDC DWPESITSGF PGPQFGPSVA REKLDAGERP
160 170 180 190 200
VLATVPKPKV GLSTDAHARI GEEAWRGGVD LLKDDENLTD QAFNPFADRL
210 220 230 240 250
AESLAARDRA QEETGERKDY LVNVTAETTE MLERVDLVAE HGGGFVMVDV
260 270 280 290 300
ITCGWAAVQS VRERCEDHGL AIHAHRAMHA AFDRLDHHGV SMRVIAQIAR
310 320 330 340 350
LCGVDHIHTG TAGLGKLANE DTPGINEWLT SDCHGLRPVL PVASGGLHPG
360 370 380 390 400
VVDQLIDALG TDIIVQAGGG IHGHPDGTHA GAKALRQSVE ASMAGTDLET
410 420
YADDHAELAT ALEKWGAETP R
Length:421
Mass (Da):44,615
Last modified:October 3, 2012 - v1
Checksum:i948B35B16AA05268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003412 Genomic DNA. Translation: AFO56068.1.
RefSeqiWP_014863184.1. NC_018224.1.
YP_006540144.1. NC_018224.1.

Genome annotation databases

EnsemblBacteriaiAFO56068; AFO56068; NJ7G_0819.
GeneIDi13350656.
KEGGinat:NJ7G_0819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003412 Genomic DNA. Translation: AFO56068.1 .
RefSeqi WP_014863184.1. NC_018224.1.
YP_006540144.1. NC_018224.1.

3D structure databases

ProteinModelPortali I7CQ19.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFO56068 ; AFO56068 ; NJ7G_0819 .
GeneIDi 13350656.
KEGGi nat:NJ7G_0819.

Phylogenomic databases

KOi K01601.

Enzyme and pathway databases

BioCyci NSP406552:GLHM-827-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable of growth on synthetic media without amino acid supplements."
    Feng J., Liu B., Zhang Z., Ren Y., Li Y., Gan F., Huang Y., Chen X., Shen P., Wang L., Tang B., Tang X.F.
    PLoS ONE 7:E41621-E41621(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J7-2Imported.

Entry informationi

Entry nameiI7CQ19_NATSJ
AccessioniPrimary (citable) accession number: I7CQ19
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3