ID   I6YW07_HUMAN            Unreviewed;       327 AA.
AC   I6YW07;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AFN61267.1};
DE   Flags: Fragment;
GN   Name=HLA-B {ECO:0000313|EMBL:AFN61267.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AFN61267.1};
RN   [1] {ECO:0000313|EMBL:AFN61267.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23216293; DOI=10.1111/tan.12038;
RA   Caggiari L., De Zorzi M., Izzo F., Tornesello M.L., Buonaguro F.M.,
RA   De Re V.;
RT   "Identification and sequence analysis of a novel human leukocyte antigen
RT   allele B*51:141.";
RL   Tissue Antigens 81:55-56(2013).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; JQ965996; AFN61267.1; -; Genomic_DNA.
DR   AlphaFoldDB; I6YW07; -.
DR   PeptideAtlas; I6YW07; -.
DR   ChiTaRS; HLA-B; human.
DR   GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   CDD; cd21026; IgC1_MHC_Ia_HLA-B; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022451};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC I {ECO:0000256|ARBA:ARBA00022451};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        298..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          199..285
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFN61267.1"
FT   NON_TER         327
FT                   /evidence="ECO:0000313|EMBL:AFN61267.1"
SQ   SEQUENCE   327 AA;  37191 MW;  BF28167A2FAC3FA9 CRC64;
     LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDYTQFVRF DSDAASPRTE
     PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDVGPD
     GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE
     WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
     DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG
     IVAGLAVLAV VVIGAVVATV MCRRKSS
//