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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:Rv3432cImported
ORF Names:LH57_18750Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3432c.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3432c.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CVK. Bacteria.
COG0076. LUCA.
KOiK01580.
OMAiYTGRLFT.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

I6YG46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSHPSVPA HSIAPAYTGR MFTAPVPALR MPDESMDPEA AYRFIHDELM
60 70 80 90 100
LDGSSRLNLA TFVTTWMDPE AEKLMAETFD KNMIDKDEYP ATAAIEARCV
110 120 130 140 150
SMVADLFHAE GLRDHDPTSA TGVSTIGSSE AVMLGGLALK WRWRQRVGSW
160 170 180 190 200
KGRMPNLVMG SNVQVVWEKF CRYFDVEPRY LPMERGRYVI TPEQVLAAVD
210 220 230 240 250
ENTIGVVAIL GTTYTGELEP IAEICAALDK LAAGGGVDVP VHVDAASGGF
260 270 280 290 300
VVPFLHPDLV WDFRLPRVVS INVSGHKYGL TYPGVGFVVW RGPEHLPEDL
310 320 330 340 350
VFRVNYLGGD MPTFTLNFSR PGNQVVGQYY NFLRLGRDGY TKVMQALSHT
360 370 380 390 400
ARWLGDQLRE VDHCEVISDG SAIPVVSFRL AGDRGYTEFD VSHELRTFGW
410 420 430 440 450
QVPAYTMPDN ATDVAVLRIV VREGLSADLA RALHDDAVTA LAALDKVKPG
460
GHFDAQHFAH
Length:460
Mass (Da):50,780
Last modified:October 3, 2012 - v1
Checksum:iB5DA3156D4C7CB4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16227.1.
AL123456 Genomic DNA. Translation: CCP46254.1.
RefSeqiNP_217949.1. NC_000962.3.
WP_003418277.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR16227; AIR16227; LH57_18750.
CCP46254; CCP46254; Rv3432c.
GeneIDi887580.
KEGGimtu:Rv3432c.
mtv:RVBD_3432c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16227.1.
AL123456 Genomic DNA. Translation: CCP46254.1.
RefSeqiNP_217949.1. NC_000962.3.
WP_003418277.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3432c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR16227; AIR16227; LH57_18750.
CCP46254; CCP46254; Rv3432c.
GeneIDi887580.
KEGGimtu:Rv3432c.
mtv:RVBD_3432c.

Organism-specific databases

TubercuListiRv3432c.

Phylogenomic databases

eggNOGiENOG4105CVK. Bacteria.
COG0076. LUCA.
KOiK01580.
OMAiYTGRLFT.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiI6YG46_MYCTU
AccessioniPrimary (citable) accession number: I6YG46
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: March 16, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.