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I6YEH6

- I6YEH6_MYCTU

UniProt

I6YEH6 - I6YEH6_MYCTU

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Protein
Submitted name: Enoyl-CoA hydratase EchA16
Gene
echA16, Rv2831, P425_02948, RVBD_2831
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421Acetate; via carbonyl oxygenImported
Binding sitei167 – 1671Acetate; via carbonyl oxygenImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Enoyl-CoA hydratase EchA16Imported
    Submitted name:
    Probable enoyl-CoA hydratase EchA16 (Enoyl hydrase) (Unsaturated acyl-CoA hydratase) (Crotonase)Imported
    Gene namesi
    Name:echA16Imported
    Ordered Locus Names:Rv2831Imported
    ORF Names:P425_02948Imported, RVBD_2831Imported
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome, UP000003123: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi83332.Rv2831.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JJTX-ray2.50A/B/C1-249[»]

    Family & Domainsi

    Phylogenomic databases

    KOiK01692.
    OMAiGLWQEAM.
    OrthoDBiEOG6M9F0M.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I6YEH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDDILLIDT DERVRTLTLN RPQSRNALSA ALRDRFFAAL ADAEADDDID    50
    VVILTGADPV FCAGLDLKEL AGQTALPDIS PRWPAMTKPV IGAINGAAVT 100
    GGLELALYCD ILIASEHARF ADTHARVGLL PTWGLSVRLP QKVGIGLARR 150
    MSLTGDYLSA TDALRAGLVT EVVAHDQLLP TARRVAASIV GNNQNAVRAL 200
    LASYHRIDES QTAAGLWLEA CAAKQFRTSG DTIAANREAV LQRGRAQVR 249
    Length:249
    Mass (Da):26,630
    Last modified:October 3, 2012 - v1
    Checksum:i1605D9AFFE1C67F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN50810.1.
    AL123456 Genomic DNA. Translation: CCP45632.1.
    JLDD01000034 Genomic DNA. Translation: KBJ30217.1.
    RefSeqiNP_217347.1. NC_000962.3.
    YP_006516281.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiAFN50810; AFN50810; RVBD_2831.
    GeneIDi13317620.
    888519.
    KEGGimtu:Rv2831.
    mtv:RVBD_2831.
    PATRICi18128142. VBIMycTub22151_3170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN50810.1 .
    AL123456 Genomic DNA. Translation: CCP45632.1 .
    JLDD01000034 Genomic DNA. Translation: KBJ30217.1 .
    RefSeqi NP_217347.1. NC_000962.3.
    YP_006516281.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JJT X-ray 2.50 A/B/C 1-249 [» ]
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv2831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN50810 ; AFN50810 ; RVBD_2831 .
    GeneIDi 13317620.
    888519.
    KEGGi mtu:Rv2831.
    mtv:RVBD_2831.
    PATRICi 18128142. VBIMycTub22151_3170.

    Phylogenomic databases

    KOi K01692.
    OMAi GLWQEAM.
    OrthoDBi EOG6M9F0M.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv and H37RvImported.
    2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
      Camus J.C., Pryor M.J., Medigue C., Cole S.T.
      Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    5. Lew J.M.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    6. "The crystal structure of enoyl-CoA hydratase from Mycobacterium tuberculosis H37Rv."
      Tan K., Holowicki J., Endres M., Kim C.-Y., Kim H., Hung L.-W., Terwilliger T.C., Joachimiak A.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.

    Entry informationi

    Entry nameiI6YEH6_MYCTU
    AccessioniPrimary (citable) accession number: I6YEH6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: September 3, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteome

    External Data

    Dasty 3

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