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I6YEH6

- I6YEH6_MYCTU

UniProt

I6YEH6 - I6YEH6_MYCTU

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Protein
Submitted name:

Enoyl-CoA hydratase

Gene

echA16

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421Acetate; via carbonyl oxygenImported
Binding sitei167 – 1671Acetate; via carbonyl oxygenImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Enoyl-CoA hydrataseImported (EC:4.2.1.17Imported)
Submitted name:
Enoyl-CoA hydratase EchA16Imported
Submitted name:
Probable enoyl-CoA hydratase EchA16 (Enoyl hydrase) (Unsaturated acyl-CoA hydratase) (Crotonase)Imported
Gene namesi
Name:echA16Imported
Ordered Locus Names:Rv2831Imported, RVBD_2831Imported
ORF Names:LH57_15455Imported, P425_02948Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome, UP000003123: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2831.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JJTX-ray2.50A/B/C1-249[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01692.
OMAiGLWQEAM.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

I6YEH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDDILLIDT DERVRTLTLN RPQSRNALSA ALRDRFFAAL ADAEADDDID
60 70 80 90 100
VVILTGADPV FCAGLDLKEL AGQTALPDIS PRWPAMTKPV IGAINGAAVT
110 120 130 140 150
GGLELALYCD ILIASEHARF ADTHARVGLL PTWGLSVRLP QKVGIGLARR
160 170 180 190 200
MSLTGDYLSA TDALRAGLVT EVVAHDQLLP TARRVAASIV GNNQNAVRAL
210 220 230 240
LASYHRIDES QTAAGLWLEA CAAKQFRTSG DTIAANREAV LQRGRAQVR
Length:249
Mass (Da):26,630
Last modified:October 3, 2012 - v1
Checksum:i1605D9AFFE1C67F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003248 Genomic DNA. Translation: AFN50810.1.
CP009480 Genomic DNA. Translation: AIR15605.1.
AL123456 Genomic DNA. Translation: CCP45632.1.
JLDD01000034 Genomic DNA. Translation: KBJ30217.1.
RefSeqiNP_217347.1. NC_000962.3.
YP_006516281.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN50810; AFN50810; RVBD_2831.
GeneIDi13317620.
888519.
KEGGimtu:Rv2831.
mtv:RVBD_2831.
PATRICi18128142. VBIMycTub22151_3170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003248 Genomic DNA. Translation: AFN50810.1 .
CP009480 Genomic DNA. Translation: AIR15605.1 .
AL123456 Genomic DNA. Translation: CCP45632.1 .
JLDD01000034 Genomic DNA. Translation: KBJ30217.1 .
RefSeqi NP_217347.1. NC_000962.3.
YP_006516281.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JJT X-ray 2.50 A/B/C 1-249 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 83332.Rv2831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFN50810 ; AFN50810 ; RVBD_2831 .
GeneIDi 13317620.
888519.
KEGGi mtu:Rv2831.
mtv:RVBD_2831.
PATRICi 18128142. VBIMycTub22151_3170.

Phylogenomic databases

KOi K01692.
OMAi GLWQEAM.
OrthoDBi EOG6M9F0M.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
    Camus J.C., Pryor M.J., Medigue C., Cole S.T.
    Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  5. Lew J.M.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  6. "The crystal structure of enoyl-CoA hydratase from Mycobacterium tuberculosis H37Rv."
    Tan K., Holowicki J., Endres M., Kim C.-Y., Kim H., Hung L.-W., Terwilliger T.C., Joachimiak A.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  10. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.

Entry informationi

Entry nameiI6YEH6_MYCTU
AccessioniPrimary (citable) accession number: I6YEH6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3