Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-quinone oxidoreductase subunit A

Gene

nuoA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTransportUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit AUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit AUniRule annotation
NDH-1 subunit AUniRule annotation
NUO1UniRule annotation
Gene namesi
Name:nuoAUniRule annotation
ORF Names:LH57_17170Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000031768 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalUniRule annotationAdd BLAST23
Transmembranei70 – 91HelicalUniRule annotationAdd BLAST22
Transmembranei97 – 119HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

QuinoneUniRule annotation

Proteomic databases

PaxDbiI6YBB8.

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI6YBB8.
SMRiI6YBB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105KWU. Bacteria.
COG0838. LUCA.
KOiK00330.
OMAiAYEWRRG.
PhylomeDBiI6YBB8.

Family and domain databases

HAMAPiMF_01394. NDH1_NuoA. 1 hit.
InterProiView protein in InterPro
IPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiView protein in Pfam
PF00507. Oxidored_q4. 1 hit.

Sequencei

Sequence statusi: Complete.

I6YBB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVYIPILVL AALAAAFAVV SVVIASLVGP SRFNRSKQAA YECGIEPAST
60 70 80 90 100
GARTSIGPGA ASGQRFPIKY YLTAMLFIVF DIEIVFLYPW AVSYDSLGTF
110 120
ALVEMAIFML TVFVAYAYVW RRGGLTWD
Length:128
Mass (Da):13,975
Last modified:October 3, 2012 - v1
Checksum:iDDF4FD3F77A8149A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15929.1.
RefSeqiNP_217661.1. NC_000962.3.
WP_003416417.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15929; AIR15929; LH57_17170.
GeneIDi887397.
KEGGimtu:Rv3145.
mtv:RVBD_3145.
PATRICifig|83332.111.peg.3504.

Similar proteinsi

Entry informationi

Entry nameiI6YBB8_MYCTU
AccessioniPrimary (citable) accession number: I6YBB8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 5, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported