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Protein

Probable DNA ligase

Gene

ligB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1
Active sitei211N6-AMP-lysine intermediateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei231ATPUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei300ATPUniRule annotation1
Binding sitei372ATPUniRule annotation1
Binding sitei378ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
ORF Names:LH57_16715Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000031768 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiI6YB16.
PRIDEiI6YB16.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3062.

Structurei

3D structure databases

ProteinModelPortaliI6YB16.
SMRiI6YB16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 412DNA_LIGASE_A3InterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QIM. Bacteria.
COG1793. LUCA.
KOiK10747.
OMAiRKHNIEE.
PhylomeDBiI6YB16.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6YB16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLHDVAITS MDVAATSSRL TKVARIAALL HRAAPDTQLV TIIVSWLSGE
60 70 80 90 100
LPQRHIGVGW AALRSLPPPA PQPALTVTGV DATLSKIGTL PGKGSQAQRA
110 120 130 140 150
ALVAELFSAA TEAEQTFLLR LLGGELRQGA KGGIMADAVA QAAGLPAATV
160 170 180 190 200
QRAAMLGGDL AAAAAAGLSG AALDTFTLRV GRPIGPMLAQ TATSVHDALE
210 220 230 240 250
RHGGTTIFEA KLDGARVQIH RANDQVRIYT RSLDDVTARL PEVVEATLAL
260 270 280 290 300
PVRDLVADGE AIALCPDNRP QRFQVTASRF GRSVDVAAAR ATQPLSVFFF
310 320 330 340 350
DILHRDGTDL LEAPTTERLA ALDALVPARH RVDRLITSDP TDAANFLDAT
360 370 380 390 400
LAAGHEGVMA KAPAARYLAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRR
410 420 430 440 450
GKLSNIHLGA RDPATGGFVM VGKTFKGMTD AMLDWQTTRF HEIAVGPTDG
460 470 480 490 500
YVVQLRPEQV VEVALDGVQR SSRYPGGLAL RFARVVRYRA DKDPAEADTI

DAVRALY
Length:507
Mass (Da):53,737
Last modified:October 3, 2012 - v1
Checksum:iA382F41A7B9E5741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15843.1.
RefSeqiNP_217578.1. NC_000962.3.
WP_003912069.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15843; AIR15843; LH57_16715.
GeneIDi887553.
KEGGimtu:Rv3062.
mtv:RVBD_3062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15843.1.
RefSeqiNP_217578.1. NC_000962.3.
WP_003912069.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliI6YB16.
SMRiI6YB16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3062.

Proteomic databases

PaxDbiI6YB16.
PRIDEiI6YB16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR15843; AIR15843; LH57_16715.
GeneIDi887553.
KEGGimtu:Rv3062.
mtv:RVBD_3062.

Phylogenomic databases

eggNOGiENOG4107QIM. Bacteria.
COG1793. LUCA.
KOiK10747.
OMAiRKHNIEE.
PhylomeDBiI6YB16.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI6YB16_MYCTU
AccessioniPrimary (citable) accession number: I6YB16
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.