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I6YB16 (I6YB16_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407

EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
ORF Names:P425_03190 EMBL KBJ29106.1, RVBD_3062 EMBL AFN51052.1
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [Complete proteome] [HAMAP] EMBL AFN51052.1
Taxonomic identifier83332 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407 RuleBase RU000617

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2111N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2091ATP By similarity HAMAP-Rule MF_00407
Binding site2161ATP By similarity HAMAP-Rule MF_00407
Binding site2311ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site3001ATP By similarity HAMAP-Rule MF_00407
Binding site3721ATP By similarity HAMAP-Rule MF_00407
Binding site3781ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
I6YB16 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: A382F41A7B9E5741

FASTA50753,737
        10         20         30         40         50         60 
MLLHDVAITS MDVAATSSRL TKVARIAALL HRAAPDTQLV TIIVSWLSGE LPQRHIGVGW 

        70         80         90        100        110        120 
AALRSLPPPA PQPALTVTGV DATLSKIGTL PGKGSQAQRA ALVAELFSAA TEAEQTFLLR 

       130        140        150        160        170        180 
LLGGELRQGA KGGIMADAVA QAAGLPAATV QRAAMLGGDL AAAAAAGLSG AALDTFTLRV 

       190        200        210        220        230        240 
GRPIGPMLAQ TATSVHDALE RHGGTTIFEA KLDGARVQIH RANDQVRIYT RSLDDVTARL 

       250        260        270        280        290        300 
PEVVEATLAL PVRDLVADGE AIALCPDNRP QRFQVTASRF GRSVDVAAAR ATQPLSVFFF 

       310        320        330        340        350        360 
DILHRDGTDL LEAPTTERLA ALDALVPARH RVDRLITSDP TDAANFLDAT LAAGHEGVMA 

       370        380        390        400        410        420 
KAPAARYLAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRR GKLSNIHLGA RDPATGGFVM 

       430        440        450        460        470        480 
VGKTFKGMTD AMLDWQTTRF HEIAVGPTDG YVVQLRPEQV VEVALDGVQR SSRYPGGLAL 

       490        500 
RFARVVRYRA DKDPAEADTI DAVRALY 

« Hide

References

« Hide 'large scale' references
[1]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL AFN51052.1.
[2]"The genome sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[3]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C. expand/collapse author list , Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL KBJ29106.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003248 Genomic DNA. Translation: AFN51052.1.
JLDD01000038 Genomic DNA. Translation: KBJ29106.1.
RefSeqNP_217578.1. NC_000962.3.
YP_006516523.1. NC_018143.2.

3D structure databases

ProteinModelPortalI6YB16.
SMRI6YB16. Positions 76-507.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFN51052; AFN51052; RVBD_3062.
GeneID887553.
KEGGmtu:Rv3062.
mtv:RVBD_3062.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01971.
OMAARVQVHK.
PhylomeDBI6YB16.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI6YB16_MYCTU
AccessionPrimary (citable) accession number: I6YB16
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)