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Protein

Alanine racemase

Gene

MYCMA_2054

Organism
Mycobacterium abscessus subsp. bolletii str. GO 06
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Active sitei291 – 2911Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei339 – 3391Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMMAS1198627:GLGQ-2051-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:MYCMA_2054Imported
OrganismiMycobacterium abscessus subsp. bolletii str. GO 06Imported
Taxonomic identifieri1198627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
ProteomesiUP000009008: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI6Y8F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6Y8F6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPVSTTSTT TDGLPPSTGA TAAQAVIDLG AIAHNVKLLR EHAGTARLMA
60 70 80 90 100
VVKADGYGHG AVRVARAALA AGADELGVTS ITEALQIRAA GLDAPLLAWL
110 120 130 140 150
HAPGADYAAA LHADVEVAVS SLGQLGELLA AARSTGRQAI TSIKVDTGLN
160 170 180 190 200
RNGVPAGYTR DLFEALAKAQ AEESIRLRGI MSHFAYADQP GHPTIDMQIG
210 220 230 240 250
RFNEALELAR GFGLRYELAH LSNSAATLTR PDARYDMVRP GIAVYGINPL
260 270 280 290 300
GAAESATSNR GRTSFDLIPA MSLTCAVSSV KPVSAGEGVS YGHVWTAPRD
310 320 330 340 350
TNAALIGIGY ADGVVRGLGN RFEVAIGGRR YPNIGRVCMD QFVVDLGDND
360 370 380 390 400
AGVQAGDVAT LFGPGTAGEP TAQDWAELLD TIAYEVVTGP RGRVVRTYRD

SRAVE
Length:405
Mass (Da):42,125
Last modified:October 3, 2012 - v1
Checksum:iB8268AA68E52083D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003699 Genomic DNA. Translation: AFN64186.1.
RefSeqiYP_006521793.1. NC_018150.2.

Genome annotation databases

EnsemblBacteriaiAFN64186; AFN64186; MYCMA_2054.
GeneIDi13324526.
KEGGimmv:MYCMA_2054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003699 Genomic DNA. Translation: AFN64186.1.
RefSeqiYP_006521793.1. NC_018150.2.

3D structure databases

ProteinModelPortaliI6Y8F6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN64186; AFN64186; MYCMA_2054.
GeneIDi13324526.
KEGGimmv:MYCMA_2054.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMMAS1198627:GLGQ-2051-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GO 06Imported.

Entry informationi

Entry nameiI6Y8F6_MYCAB
AccessioniPrimary (citable) accession number: I6Y8F6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.