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I6Y8F6

- I6Y8F6_MYCAB

UniProt

I6Y8F6 - I6Y8F6_MYCAB

Protein

Alanine racemase

Gene

MYCMA_2054

Organism
Mycobacterium abscessus subsp. bolletii str. GO 06
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Active sitei291 – 2911Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei339 – 3391Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMMAS1198627:GLGQ-2051-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:MYCMA_2054Imported
    OrganismiMycobacterium abscessus subsp. bolletii str. GO 06Imported
    Taxonomic identifieri1198627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
    ProteomesiUP000009008: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI6Y8F6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I6Y8F6-1 [UniParc]FASTAAdd to Basket

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    MGPVSTTSTT TDGLPPSTGA TAAQAVIDLG AIAHNVKLLR EHAGTARLMA    50
    VVKADGYGHG AVRVARAALA AGADELGVTS ITEALQIRAA GLDAPLLAWL 100
    HAPGADYAAA LHADVEVAVS SLGQLGELLA AARSTGRQAI TSIKVDTGLN 150
    RNGVPAGYTR DLFEALAKAQ AEESIRLRGI MSHFAYADQP GHPTIDMQIG 200
    RFNEALELAR GFGLRYELAH LSNSAATLTR PDARYDMVRP GIAVYGINPL 250
    GAAESATSNR GRTSFDLIPA MSLTCAVSSV KPVSAGEGVS YGHVWTAPRD 300
    TNAALIGIGY ADGVVRGLGN RFEVAIGGRR YPNIGRVCMD QFVVDLGDND 350
    AGVQAGDVAT LFGPGTAGEP TAQDWAELLD TIAYEVVTGP RGRVVRTYRD 400
    SRAVE 405
    Length:405
    Mass (Da):42,125
    Last modified:October 3, 2012 - v1
    Checksum:iB8268AA68E52083D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003699 Genomic DNA. Translation: AFN64186.1.
    RefSeqiYP_006521793.1. NC_018150.1.

    Genome annotation databases

    EnsemblBacteriaiAFN64186; AFN64186; MYCMA_2054.
    GeneIDi13324526.
    KEGGimmv:MYCMA_2054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003699 Genomic DNA. Translation: AFN64186.1 .
    RefSeqi YP_006521793.1. NC_018150.1.

    3D structure databases

    ProteinModelPortali I6Y8F6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN64186 ; AFN64186 ; MYCMA_2054 .
    GeneIDi 13324526.
    KEGGi mmv:MYCMA_2054.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MMAS1198627:GLGQ-2051-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GO 06Imported.

    Entry informationi

    Entry nameiI6Y8F6_MYCAB
    AccessioniPrimary (citable) accession number: I6Y8F6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3