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Protein
Submitted name:

Crp/Fnr family transcriptional regulator

Gene

LH57_20030

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 82cAMPCombined sources4
Nucleotide bindingi89 – 91cAMPCombined sources3
Nucleotide bindingi134 – 135cAMPCombined sources2
DNA bindingi177 – 196H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandcAMPCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Crp/Fnr family transcriptional regulatorImported
Gene namesi
Ordered Locus Names:LH57_20030Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000031768 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiI6Y496.
PRIDEiI6Y496.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A2UX-ray2.63A/B/C/D/E/F/G/H1-224[»]
ProteinModelPortaliI6Y496.
SMRiI6Y496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 130Cyclic nucleotide-bindingInterPro annotationAdd BLAST121
Domaini144 – 217HTH crp-typeInterPro annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG4105IJJ. Bacteria.
COG0664. LUCA.
KOiK10914.
OMAiTECEVAE.
PhylomeDBiI6Y496.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

I6Y496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEILARAGI FQGVEPSAIA ALTKQLQPVD FPRGHTVFAE GEPGDRLYII
60 70 80 90 100
ISGKVKIGRR APDGRENLLT IMGPSDMFGE LSIFDPGPRT SSATTITEVR
110 120 130 140 150
AVSMDRDALR SWIADRPEIS EQLLRVLARR LRRTNNNLAD LIFTDVPGRV
160 170 180 190 200
AKQLLQLAQR FGTQEGGALR VTHDLTQEEI AQLVGASRET VNKALADFAH
210 220
RGWIRLEGKS VLISDSERLA RRAR
Length:224
Mass (Da):24,791
Last modified:October 3, 2012 - v1
Checksum:iBAB89A61B64839E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16463.1.
RefSeqiNP_218193.1. NC_000962.3.
WP_003419728.1. NZ_KK339374.1.

Genome annotation databases

EnsemblBacteriaiAIR16463; AIR16463; LH57_20030.
GeneIDi885502.
KEGGimtu:Rv3676.
mtv:RVBD_3676.
PATRICifig|83332.111.peg.4087.

Similar proteinsi

Entry informationi

Entry nameiI6Y496_MYCTU
AccessioniPrimary (citable) accession number: I6Y496
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 27, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported