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I6Y496

- I6Y496_MYCTU

UniProt

I6Y496 - I6Y496_MYCTU

Protein
Submitted name:

Transcriptional regulator Crp

Gene

P425_03821

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 824cAMPImported
    Nucleotide bindingi89 – 913cAMPImported
    Nucleotide bindingi134 – 1352cAMPImported

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    cAMPImported, DNA-bindingSAAS annotation, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transcriptional regulator CrpImported
    Gene namesi
    ORF Names:P425_03821Imported, RVBD_3676Imported
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000003123: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4A2UX-ray2.63A/B/C/D/E/F/G/H1-224[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains HTH crp-type DNA-binding domain.SAAS annotation
    Contains cyclic nucleotide-binding domain.SAAS annotation

    Phylogenomic databases

    OMAiMVFTDVP.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I6Y496-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEILARAGI FQGVEPSAIA ALTKQLQPVD FPRGHTVFAE GEPGDRLYII    50
    ISGKVKIGRR APDGRENLLT IMGPSDMFGE LSIFDPGPRT SSATTITEVR 100
    AVSMDRDALR SWIADRPEIS EQLLRVLARR LRRTNNNLAD LIFTDVPGRV 150
    AKQLLQLAQR FGTQEGGALR VTHDLTQEEI AQLVGASRET VNKALADFAH 200
    RGWIRLEGKS VLISDSERLA RRAR 224
    Length:224
    Mass (Da):24,791
    Last modified:October 3, 2012 - v1
    Checksum:iBAB89A61B64839E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN51693.1.
    JLDD01000048 Genomic DNA. Translation: KBJ24746.1.
    RefSeqiNP_218193.1. NC_000962.3.
    YP_006517164.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiAFN51693; AFN51693; RVBD_3676.
    GeneIDi13317285.
    885502.
    KEGGimtu:Rv3676.
    mtv:RVBD_3676.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN51693.1 .
    JLDD01000048 Genomic DNA. Translation: KBJ24746.1 .
    RefSeqi NP_218193.1. NC_000962.3.
    YP_006517164.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4A2U X-ray 2.63 A/B/C/D/E/F/G/H 1-224 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN51693 ; AFN51693 ; RVBD_3676 .
    GeneIDi 13317285.
    885502.
    KEGGi mtu:Rv3676.
    mtv:RVBD_3676.

    Phylogenomic databases

    OMAi MVFTDVP.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A New Crystal Form of Crp from M. Tuberculosis and Conformational Effects of Crystal Packing."
      Kim S.-K., Robinson H., Reddy P.T., Gallagher D.T.
      Submitted (SEP-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) IN COMPLEX WITH CAMP.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37RvImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.

    Entry informationi

    Entry nameiI6Y496_MYCTU
    AccessioniPrimary (citable) accession number: I6Y496
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3