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I6Y496

- I6Y496_MYCTU

UniProt

I6Y496 - I6Y496_MYCTU

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Protein
Submitted name:

Crp/Fnr family transcriptional regulator

Gene

RVBD_3676

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 824cAMPImported
Nucleotide bindingi89 – 913cAMPImported
Nucleotide bindingi134 – 1352cAMPImported

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

cAMPImported, DNA-bindingSAAS annotation, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Crp/Fnr family transcriptional regulatorImported
Submitted name:
Transcriptional regulator CrpImported
Gene namesi
Ordered Locus Names:RVBD_3676Imported
ORF Names:LH57_20030Imported, P425_03821Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000003123: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A2UX-ray2.63A/B/C/D/E/F/G/H1-224[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains HTH crp-type DNA-binding domain.SAAS annotation
Contains cyclic nucleotide-binding domain.SAAS annotation

Phylogenomic databases

OMAiMVFTDVP.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6Y496-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEILARAGI FQGVEPSAIA ALTKQLQPVD FPRGHTVFAE GEPGDRLYII
60 70 80 90 100
ISGKVKIGRR APDGRENLLT IMGPSDMFGE LSIFDPGPRT SSATTITEVR
110 120 130 140 150
AVSMDRDALR SWIADRPEIS EQLLRVLARR LRRTNNNLAD LIFTDVPGRV
160 170 180 190 200
AKQLLQLAQR FGTQEGGALR VTHDLTQEEI AQLVGASRET VNKALADFAH
210 220
RGWIRLEGKS VLISDSERLA RRAR
Length:224
Mass (Da):24,791
Last modified:October 3, 2012 - v1
Checksum:iBAB89A61B64839E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003248 Genomic DNA. Translation: AFN51693.1.
CP009480 Genomic DNA. Translation: AIR16463.1.
JLDD01000048 Genomic DNA. Translation: KBJ24746.1.
RefSeqiNP_218193.1. NC_000962.3.
YP_006517164.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN51693; AFN51693; RVBD_3676.
GeneIDi13317285.
885502.
KEGGimtu:Rv3676.
mtv:RVBD_3676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003248 Genomic DNA. Translation: AFN51693.1 .
CP009480 Genomic DNA. Translation: AIR16463.1 .
JLDD01000048 Genomic DNA. Translation: KBJ24746.1 .
RefSeqi NP_218193.1. NC_000962.3.
YP_006517164.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4A2U X-ray 2.63 A/B/C/D/E/F/G/H 1-224 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFN51693 ; AFN51693 ; RVBD_3676 .
GeneIDi 13317285.
885502.
KEGGi mtu:Rv3676.
mtv:RVBD_3676.

Phylogenomic databases

OMAi MVFTDVP.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A New Crystal Form of Crp from M. Tuberculosis and Conformational Effects of Crystal Packing."
    Kim S.-K., Robinson H., Reddy P.T., Gallagher D.T.
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) IN COMPLEX WITH CAMP.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  5. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.

Entry informationi

Entry nameiI6Y496_MYCTU
AccessioniPrimary (citable) accession number: I6Y496
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3