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Protein
Submitted name:

Crp/Fnr family transcriptional regulator

Gene

LH57_20030

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 824cAMPCombined sources
Nucleotide bindingi89 – 913cAMPCombined sources
Nucleotide bindingi134 – 1352cAMPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

cAMPCombined sources, DNA-bindingSAAS annotation, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Crp/Fnr family transcriptional regulatorImported
Gene namesi
ORF Names:LH57_20030Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3676.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A2UX-ray2.63A/B/C/D/E/F/G/H1-224[»]
ProteinModelPortaliI6Y496.
SMRiI6Y496. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains HTH crp-type DNA-binding domain.SAAS annotation
Contains cyclic nucleotide-binding domain.SAAS annotation

Phylogenomic databases

OMAiFLMVLCR.
PhylomeDBiI6Y496.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6Y496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEILARAGI FQGVEPSAIA ALTKQLQPVD FPRGHTVFAE GEPGDRLYII
60 70 80 90 100
ISGKVKIGRR APDGRENLLT IMGPSDMFGE LSIFDPGPRT SSATTITEVR
110 120 130 140 150
AVSMDRDALR SWIADRPEIS EQLLRVLARR LRRTNNNLAD LIFTDVPGRV
160 170 180 190 200
AKQLLQLAQR FGTQEGGALR VTHDLTQEEI AQLVGASRET VNKALADFAH
210 220
RGWIRLEGKS VLISDSERLA RRAR
Length:224
Mass (Da):24,791
Last modified:October 3, 2012 - v1
Checksum:iBAB89A61B64839E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16463.1.
RefSeqiNP_218193.1. NC_000962.3.
WP_003419728.1. NZ_KK339374.1.
YP_006517164.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN51693; AFN51693; RVBD_3676.
KBJ24746; KBJ24746; P425_03821.
GeneIDi885502.
KEGGimtu:Rv3676.
mtv:RVBD_3676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16463.1.
RefSeqiNP_218193.1. NC_000962.3.
WP_003419728.1. NZ_KK339374.1.
YP_006517164.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A2UX-ray2.63A/B/C/D/E/F/G/H1-224[»]
ProteinModelPortaliI6Y496.
SMRiI6Y496. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN51693; AFN51693; RVBD_3676.
KBJ24746; KBJ24746; P425_03821.
GeneIDi885502.
KEGGimtu:Rv3676.
mtv:RVBD_3676.

Phylogenomic databases

OMAiFLMVLCR.
PhylomeDBiI6Y496.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A New Crystal Form of Crp from M. Tuberculosis and Conformational Effects of Crystal Packing."
    Kim S.-K., Robinson H., Reddy P.T., Gallagher D.T.
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) IN COMPLEX WITH CAMP.
  2. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported.

Entry informationi

Entry nameiI6Y496_MYCTU
AccessioniPrimary (citable) accession number: I6Y496
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 24, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.