SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

I6Y496

- I6Y496_MYCTU

UniProt

I6Y496 - I6Y496_MYCTU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Transcriptional regulator Crp

Gene
P425_03821, RVBD_3676
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 824cAMPImported
Nucleotide bindingi89 – 913cAMPImported
Nucleotide bindingi134 – 1352cAMPImported

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

cAMPImported, DNA-bindingSAAS annotations, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator CrpImported
Gene namesi
ORF Names:P425_03821Imported, RVBD_3676Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000003123: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A2UX-ray2.63A/B/C/D/E/F/G/H1-224[»]

Family & Domainsi

Sequence similaritiesi

Contains HTH crp-type DNA-binding domain.SAAS annotations
Contains cyclic nucleotide-binding domain.SAAS annotations

Phylogenomic databases

OMAiMVFTDVP.
PhylomeDBiI6Y496.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6Y496-1 [UniParc]FASTAAdd to Basket

« Hide

MDEILARAGI FQGVEPSAIA ALTKQLQPVD FPRGHTVFAE GEPGDRLYII    50
ISGKVKIGRR APDGRENLLT IMGPSDMFGE LSIFDPGPRT SSATTITEVR 100
AVSMDRDALR SWIADRPEIS EQLLRVLARR LRRTNNNLAD LIFTDVPGRV 150
AKQLLQLAQR FGTQEGGALR VTHDLTQEEI AQLVGASRET VNKALADFAH 200
RGWIRLEGKS VLISDSERLA RRAR 224
Length:224
Mass (Da):24,791
Last modified:October 3, 2012 - v1
Checksum:iBAB89A61B64839E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN51693.1.
JLDD01000048 Genomic DNA. Translation: KBJ24746.1.
RefSeqiNP_218193.1. NC_000962.3.
YP_006517164.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN51693; AFN51693; RVBD_3676.
GeneIDi13317285.
885502.
KEGGimtu:Rv3676.
mtv:RVBD_3676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN51693.1 .
JLDD01000048 Genomic DNA. Translation: KBJ24746.1 .
RefSeqi NP_218193.1. NC_000962.3.
YP_006517164.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4A2U X-ray 2.63 A/B/C/D/E/F/G/H 1-224 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFN51693 ; AFN51693 ; RVBD_3676 .
GeneIDi 13317285.
885502.
KEGGi mtu:Rv3676.
mtv:RVBD_3676.

Phylogenomic databases

OMAi MVFTDVP.
PhylomeDBi I6Y496.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A New Crystal Form of Crp from M. Tuberculosis and Conformational Effects of Crystal Packing."
    Kim S.-K., Robinson H., Reddy P.T., Gallagher D.T.
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) IN COMPLEX WITH CAMP.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.

Entry informationi

Entry nameiI6Y496_MYCTU
AccessioniPrimary (citable) accession number: I6Y496
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

Similar proteinsi