Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

I6Y1N6 (I6Y1N6_PROPF) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HMPREF9154_1362 EMBL AFN47552.1
OrganismPropionibacterium propionicum (strain F0230a) [Complete proteome] [HAMAP] EMBL AFN47552.1
Taxonomic identifier767029 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain149 – 360212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding181 – 23656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3271Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3271Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3291Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I6Y1N6 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: FB7EF49FA75A50C0

FASTA37039,790
        10         20         30         40         50         60 
MSERTKIALV FGGKSSEHGI SCLTAASVLG AIDRERFDIV AVGISKSGRW SRMSLEEVAD 

        70         80         90        100        110        120 
LHITGDATPE VPEPEHDAVW LVGEHGGQVA TRVGDQLVDI QEVDVVFAPL HGPYGEDGTI 

       130        140        150        160        170        180 
QGMFEMMGIR YVGPGVLASA VGMDKHFMKL AFEAAGLPVG PYVVASERRL RLERKAVLAE 

       190        200        210        220        230        240 
VAGLGFPVFV KPARGGSSIG ITRVTDPSGL EDAIAEAQRH DPKVIFEQGF VGTRELEVAV 

       250        260        270        280        290        300 
LGDPGSPEGC RASVVGEIRV QDGDGFYDFA TKYLDDDGAA LDAPARTTPE LAARLRELAC 

       310        320        330        340        350        360 
RAFNALDAEG LVRADFFATE DQAWINEVNT MPGFTRISMY PALWQASGIP YPELVTRLIE 

       370 
LALERPVGLR 

« Hide

References

[1]"The complete genome of chromosome of Propionibacterium propionicum F0230a."
Durkin A.S., Radune D., Hostetler J., Torralba M., Gillis M., Methe B., Sutton G., Nelson K.E.
Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F0230a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002734 Genomic DNA. Translation: AFN47552.1.
RefSeqYP_006511623.1. NC_018142.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFN47552; AFN47552; HMPREF9154_1362.
GeneID13315668.
KEGGppc:HMPREF9154_1362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycPPRO767029:GLIM-1355-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI6Y1N6_PROPF
AccessionPrimary (citable) accession number: I6Y1N6
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)