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Protein

Glutamate decarboxylase

Gene

HMPREF9154_2502

Organism
Propionibacterium propionicum (strain F0230a)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciPPRO767029:GLIM-2491-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:HMPREF9154_2502Imported
OrganismiPropionibacterium propionicum (strain F0230a)Imported
Taxonomic identifieri767029 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000003118: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiFVGTWMD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

I6XZH2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQDRFIPGA CEGQAPSPER IEVAMSPSHP HRTASAGTRQ VELNPLFARP
60 70 80 90 100
GEATELPRTR LPRGESLPET AYQIVHDEAM LDGNARLNLA TFVGTWMDDH
110 120 130 140 150
ANRLALESAD KNMIDKDEYP RTAEIETRCW QMLADLWHSP DPEHTIGTST
160 170 180 190 200
IGSSEAAMLG GLALKRRWQQ ARRAAGKSAD RPNLVMSSAV QVCWEKFCNY
210 220 230 240 250
WDVEARYVPV SREHPIFDGH DLEHYVDENT IGVVAIMGIT YTGRYEPVAG
260 270 280 290 300
IAAALDRIQA ETGLDVRIHV DGASGAMVAP FLQPDLEWDF RLERVVSINT
310 320 330 340 350
SGHKYGLVYP GLGWVVWRTA DDLPEDLVFR VSYLGGDMPT FALNFSRPGS
360 370 380 390 400
QVLLQYYLFL RLGFDGYRRV HETSRSVATF LSGEIGAMDD FELCSDGTDI
410 420 430 440 450
PVFAWRLTQR PGRNWGLHDL SDRLRMKGWL VPTYPLPNDL ADELVQRVVV
460 470 480 490
RNGFSHDLAH AFLDDLRCEV DHLNTLTAPM PAITRQSGFH H
Length:491
Mass (Da):55,134
Last modified:October 3, 2012 - v1
Checksum:iB4B439F0602F93A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002734 Genomic DNA. Translation: AFN45150.1.
RefSeqiWP_014847462.1. NC_018142.1.
YP_006512678.1. NC_018142.1.

Genome annotation databases

EnsemblBacteriaiAFN45150; AFN45150; HMPREF9154_2502.
GeneIDi13314529.
KEGGippc:HMPREF9154_2502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002734 Genomic DNA. Translation: AFN45150.1.
RefSeqiWP_014847462.1. NC_018142.1.
YP_006512678.1. NC_018142.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN45150; AFN45150; HMPREF9154_2502.
GeneIDi13314529.
KEGGippc:HMPREF9154_2502.

Phylogenomic databases

KOiK01580.
OMAiFVGTWMD.

Enzyme and pathway databases

BioCyciPPRO767029:GLIM-2491-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of chromosome of Propionibacterium propionicum F0230a."
    Durkin A.S., Radune D., Hostetler J., Torralba M., Gillis M., Methe B., Sutton G., Nelson K.E.
    Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F0230aImported.

Entry informationi

Entry nameiI6XZH2_PROPF
AccessioniPrimary (citable) accession number: I6XZH2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: February 4, 2015
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.