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Protein
Submitted name:

ATP-dependent DNA ligase

Gene

LH57_05110

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-dependent DNA ligaseImported (EC:6.5.1.1Imported)
Gene namesi
ORF Names:LH57_05110Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000031768 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0938.

Structurei

3D structure databases

ProteinModelPortaliI6XWL7.
SMRiI6XWL7. Positions 3-288, 326-434, 453-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01971.
OMAiSKGIHLY.
PhylomeDBiI6XWL7.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR002755. DNA_primase_S.
IPR014146. LigD_ligase_dom.
IPR014144. LigD_PE_domain.
IPR014145. LigD_pol_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF01896. DNA_primase_S. 1 hit.
PF13298. LigD_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR02777. LigD_PE_dom. 1 hit.
TIGR02778. ligD_pol. 1 hit.
TIGR02779. NHEJ_ligase_lig. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6XWL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSASEQRVT LTNADKVLYP ATGTTKSDIF DYYAGVAEVM LGHIAGRPAT
60 70 80 90 100
RKRWPNGVDQ PAFFEKQLAL SAPPWLSRAT VAHRSGTTTY PIIDSATGLA
110 120 130 140 150
WIAQQAALEV HVPQWRFVAE PGSGELNPGP ATRLVFDLDP GEGVMMAQLA
160 170 180 190 200
EVARAVRDLL ADIGLVTFPV TSGSKGLHLY TPLDEPVSSR GATVLAKRVA
210 220 230 240 250
QRLEQAMPAL VTSTMTKSLR AGKVFVDWSQ NSGSKTTIAP YSLRGRTHPT
260 270 280 290 300
VAAPRTWAEL DDPALRQLSY DEVLTRIARD GDLLERLDAD APVADRLTRY
310 320 330 340 350
RRMRDASKTP EPIPTAKPVT GDGNTFVIQE HHARRPHYDF RLECDGVLVS
360 370 380 390 400
WAVPKNLPDN TSVNHLAIHT EDHPLEYATF EGAIPSGEYG AGKVIIWDSG
410 420 430 440 450
TYDTEKFHDD PHTGEVIVNL HGGRISGRYA LIRTNGDRWL AHRLKNQKDQ
460 470 480 490 500
KVFEFDNLAP MLATHGTVAG LKASQWAFEG KWDGYRLLVE ADHGAVRLRS
510 520 530 540 550
RSGRDVTAEY PQLRALAEDL ADHHVVLDGE AVVLDSSGVP SFSQMQNRGR
560 570 580 590 600
DTRVEFWAFD LLYLDGRALL GTRYQDRRKL LETLANATSL TVPELLPGDG
610 620 630 640 650
AQAFACSRKH GWEGVIAKRR DSRYQPGRRC ASWVKDKHWN TQEVVIGGWR
660 670 680 690 700
AGEGGRSSGV GSLLMGIPGP GGLQFAGRVG TGLSERELAN LKEMLAPLHT
710 720 730 740 750
DESPFDVPLP ARDAKGITYV KPALVAEVRY SEWTPEGRLR QSSWRGLRPD

KKPSEVVRE
Length:759
Mass (Da):83,572
Last modified:October 3, 2012 - v1
Checksum:i81BD49222EE09E36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13672.1.
RefSeqiNP_215453.1. NC_000962.3.
WP_003911307.1. NZ_KK339370.1.
YP_006514294.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN48823; AFN48823; RVBD_0938.
KBJ38700; KBJ38700; P425_00979.
GeneIDi885561.
KEGGimtu:Rv0938.
mtv:RVBD_0938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13672.1.
RefSeqiNP_215453.1. NC_000962.3.
WP_003911307.1. NZ_KK339370.1.
YP_006514294.1. NC_018143.2.

3D structure databases

ProteinModelPortaliI6XWL7.
SMRiI6XWL7. Positions 3-288, 326-434, 453-759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN48823; AFN48823; RVBD_0938.
KBJ38700; KBJ38700; P425_00979.
GeneIDi885561.
KEGGimtu:Rv0938.
mtv:RVBD_0938.

Phylogenomic databases

KOiK01971.
OMAiSKGIHLY.
PhylomeDBiI6XWL7.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR002755. DNA_primase_S.
IPR014146. LigD_ligase_dom.
IPR014144. LigD_PE_domain.
IPR014145. LigD_pol_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF01896. DNA_primase_S. 1 hit.
PF13298. LigD_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR02777. LigD_PE_dom. 1 hit.
TIGR02778. ligD_pol. 1 hit.
TIGR02779. NHEJ_ligase_lig. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported.

Entry informationi

Entry nameiI6XWL7_MYCTU
AccessioniPrimary (citable) accession number: I6XWL7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: June 24, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.