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I6XB21 (I6XB21_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01517 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP-Rule MF_01517 RuleBase RU000421

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 187NAD By similarity HAMAP-Rule MF_01517
Nucleotide binding130 – 1323NAD By similarity HAMAP-Rule MF_01517

Sites

Active site1881Proton acceptor By similarity HAMAP-Rule MF_01517
Binding site931Substrate By similarity HAMAP-Rule MF_01517
Binding site991Substrate By similarity HAMAP-Rule MF_01517
Binding site1061NAD By similarity HAMAP-Rule MF_01517
Binding site1131NAD By similarity HAMAP-Rule MF_01517
Binding site1321Substrate By similarity HAMAP-Rule MF_01517
Binding site1631Substrate By similarity HAMAP-Rule MF_01517

Sequences

Sequence LengthMass (Da)Tools
I6XB21 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: 0A512659617F9C37

FASTA32934,322
        10         20         30         40         50         60 
MSASPLKVAV TGAAGQIGYS LLFRLASGSL LGPDRPIELR LLEIEPALQA LEGVVMELDD 

        70         80         90        100        110        120 
CAFPLLSGVE IGSDPQKIFD GVSLALLVGA RPRGAGMERS DLLEANGAIF TAQGKALNAV 

       130        140        150        160        170        180 
AADDVRVGVT GNPANTNALI AMTNAPDIPR ERFSALTRLD HNRAISQLAA KTGAAVTDIK 

       190        200        210        220        230        240 
KMTIWGNHSA TQYPDLFHAE VAGKNAAEVV NDQAWIEDEF IPTVAKRGAA IIDARGASSA 

       250        260        270        280        290        300 
ASAASATIDA ARDWLLGTPA DDWVSMAVVS DGSYGVPEGL ISSFPVTTKG GNWTIVSGLE 

       310        320 
IDEFSRGRID KSTAELADER SAVTELGLI 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL AFN49144.1.
[3]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C. expand/collapse author list , Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL KBJ36253.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003248 Genomic DNA. Translation: AFN49144.1.
JLDD01000013 Genomic DNA. Translation: KBJ36253.1.
RefSeqNP_215756.1. NC_000962.3.
YP_006514615.1. NC_018143.2.

3D structure databases

ProteinModelPortalI6XB21.
SMRI6XB21. Positions 4-329.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFN49144; AFN49144; RVBD_1240.
GeneID887119.
KEGGmtu:Rv1240.
mtv:RVBD_1240.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00024.
OMAAFSQECI.
PhylomeDBI6XB21.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01517. Malate_dehydrog_2.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI6XB21_MYCTU
AccessionPrimary (citable) accession number: I6XB21
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)