Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Trehalose synthase

Gene

LH57_00710

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi140 – 1401CalciumCombined sources
Metal bindingi208 – 2081CalciumCombined sources
Metal bindingi242 – 2421Calcium; via carbonyl oxygenCombined sources
Metal bindingi243 – 2431Calcium; via carbonyl oxygenCombined sources
Metal bindingi245 – 2451CalciumCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Trehalose synthaseImported
Gene namesi
ORF Names:LH57_00710Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000031768 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0126.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LXFX-ray2.60A/B1-601[»]
ProteinModelPortaliI6X8K8.
SMRiI6X8K8. Positions 12-586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK05343.
OMAiLLNWHRR.
PhylomeDBiI6X8K8.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 3 hits.
InterProiIPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012810. TreS/a-amylase_N.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR02456. treS_nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

I6X8K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEAEHSVEH PPVQGSHVEG GVVEHPDAKD FGSAAALPAD PTWFKHAVFY
60 70 80 90 100
EVLVRAFFDA SADGSGDLRG LIDRLDYLQW LGIDCIWLPP FYDSPLRDGG
110 120 130 140 150
YDIRDFYKVL PEFGTVDDFV ALVDAAHRRG IRIITDLVMN HTSESHPWFQ
160 170 180 190 200
ESRRDPDGPY GDYYVWSDTS ERYTDARIIF VDTEESNWSF DPVRRQFYWH
210 220 230 240 250
RFFSHQPDLN YDNPAVQEAM IDVIRFWLGL GIDGFRLDAV PYLFEREGTN
260 270 280 290 300
CENLPETHAF LKRVRKVVDD EFPGRVLLAE ANQWPGDVVE YFGDPNTGGD
310 320 330 340 350
ECHMAFHFPL MPRIFMAVRR ESRFPISEII AQTPPIPDMA QWGIFLRNHD
360 370 380 390 400
ELTLEMVTDE ERDYMYAEYA KDPRMKANVG IRRRLAPLLD NDRNQIELFT
410 420 430 440 450
ALLLSLPGSP VLYYGDEIGM GDVIWLGDRD GVRIPMQWTP DRNAGFSTAN
460 470 480 490 500
PGRLYLPPSQ DPVYGYQAVN VEAQRDTSTS LLNFTRTMLA VRRRHPAFAV
510 520 530 540 550
GAFQELGGSN PSVLAYVRQV AGDDGDTVLC VNNLSRFPQP IELDLQQWTN
560 570 580 590 600
YTPVELTGHV EFPRIGQVPY LLTLPGHGFY WFQLTTHEVG APPTCGGERR

L
Length:601
Mass (Da):68,593
Last modified:October 3, 2012 - v1
Checksum:iFE52E5258F38116E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12847.1.
RefSeqiNP_214640.1. NC_000962.3.
WP_003400893.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAFN47974; AFN47974; RVBD_0126.
KBJ41232; KBJ41232; P425_00132.
GeneIDi886881.
KEGGimtu:Rv0126.
mtv:RVBD_0126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12847.1.
RefSeqiNP_214640.1. NC_000962.3.
WP_003400893.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LXFX-ray2.60A/B1-601[»]
ProteinModelPortaliI6X8K8.
SMRiI6X8K8. Positions 12-586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0126.

Chemistry

BindingDBiI6X8K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN47974; AFN47974; RVBD_0126.
KBJ41232; KBJ41232; P425_00132.
GeneIDi886881.
KEGGimtu:Rv0126.
mtv:RVBD_0126.

Phylogenomic databases

KOiK05343.
OMAiLLNWHRR.
PhylomeDBiI6X8K8.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 3 hits.
InterProiIPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012810. TreS/a-amylase_N.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR02456. treS_nterm. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis of alpha-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2."
    Roy R., Usha V., Kermani A., Scott D.J., Hyde E.I., Besra G.S., Alderwick L.J., Futterer K.
    ACS Chem. Biol. 8:2245-2255(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH CALCIUM.
  2. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported.

Entry informationi

Entry nameiI6X8K8_MYCTU
AccessioniPrimary (citable) accession number: I6X8K8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 22, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.