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I6X8K8

- I6X8K8_MYCTU

UniProt

I6X8K8 - I6X8K8_MYCTU

Protein
Submitted name:

Trehalose synthase TreS

Gene

P425_00132

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi140 – 1401CalciumImported
    Metal bindingi208 – 2081CalciumImported
    Metal bindingi242 – 2421Calcium; via carbonyl oxygenImported
    Metal bindingi243 – 2431Calcium; via carbonyl oxygenImported
    Metal bindingi245 – 2451CalciumImported

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Trehalose synthase TreSImported
    Gene namesi
    ORF Names:P425_00132Imported, RVBD_0126Imported
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000003123: Chromosome

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LXFX-ray2.60A/B1-601[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK05343.
    OMAiRMKANIG.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 3 hits.
    InterProiIPR022567. DUF3459.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR012810. TreS/a-amylase_N.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF11941. DUF3459. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR02456. treS_nterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I6X8K8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEAEHSVEH PPVQGSHVEG GVVEHPDAKD FGSAAALPAD PTWFKHAVFY    50
    EVLVRAFFDA SADGSGDLRG LIDRLDYLQW LGIDCIWLPP FYDSPLRDGG 100
    YDIRDFYKVL PEFGTVDDFV ALVDAAHRRG IRIITDLVMN HTSESHPWFQ 150
    ESRRDPDGPY GDYYVWSDTS ERYTDARIIF VDTEESNWSF DPVRRQFYWH 200
    RFFSHQPDLN YDNPAVQEAM IDVIRFWLGL GIDGFRLDAV PYLFEREGTN 250
    CENLPETHAF LKRVRKVVDD EFPGRVLLAE ANQWPGDVVE YFGDPNTGGD 300
    ECHMAFHFPL MPRIFMAVRR ESRFPISEII AQTPPIPDMA QWGIFLRNHD 350
    ELTLEMVTDE ERDYMYAEYA KDPRMKANVG IRRRLAPLLD NDRNQIELFT 400
    ALLLSLPGSP VLYYGDEIGM GDVIWLGDRD GVRIPMQWTP DRNAGFSTAN 450
    PGRLYLPPSQ DPVYGYQAVN VEAQRDTSTS LLNFTRTMLA VRRRHPAFAV 500
    GAFQELGGSN PSVLAYVRQV AGDDGDTVLC VNNLSRFPQP IELDLQQWTN 550
    YTPVELTGHV EFPRIGQVPY LLTLPGHGFY WFQLTTHEVG APPTCGGERR 600
    L 601
    Length:601
    Mass (Da):68,593
    Last modified:October 3, 2012 - v1
    Checksum:iFE52E5258F38116E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN47974.1.
    JLDD01000001 Genomic DNA. Translation: KBJ41232.1.
    RefSeqiNP_214640.1. NC_000962.3.
    YP_006513445.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiAFN47974; AFN47974; RVBD_0126.
    GeneIDi13316109.
    886881.
    KEGGimtu:Rv0126.
    mtv:RVBD_0126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN47974.1 .
    JLDD01000001 Genomic DNA. Translation: KBJ41232.1 .
    RefSeqi NP_214640.1. NC_000962.3.
    YP_006513445.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LXF X-ray 2.60 A/B 1-601 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN47974 ; AFN47974 ; RVBD_0126 .
    GeneIDi 13316109.
    886881.
    KEGGi mtu:Rv0126.
    mtv:RVBD_0126.

    Phylogenomic databases

    KOi K05343.
    OMAi RMKANIG.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 3 hits.
    InterProi IPR022567. DUF3459.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR012810. TreS/a-amylase_N.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF11941. DUF3459. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR02456. treS_nterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Synthesis of ?-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2."
      Roy R., Usha V., Kermani A., Scott D.J., Hyde E.I., Besra G.S., Alderwick L.J., Futterer K.
      ACS Chem. Biol. 8:2245-2255(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH CALCIUM.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37RvImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.

    Entry informationi

    Entry nameiI6X8K8_MYCTU
    AccessioniPrimary (citable) accession number: I6X8K8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3