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I6X8K8

- I6X8K8_MYCTU

UniProt

I6X8K8 - I6X8K8_MYCTU

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Protein
Submitted name:

Trehalose synthase TreS

Gene

P425_00132

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi140 – 1401CalciumImported
Metal bindingi208 – 2081CalciumImported
Metal bindingi242 – 2421Calcium; via carbonyl oxygenImported
Metal bindingi243 – 2431Calcium; via carbonyl oxygenImported
Metal bindingi245 – 2451CalciumImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Trehalose synthase TreSImported
Gene namesi
ORF Names:P425_00132Imported, RVBD_0126Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000003123: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LXFX-ray2.60A/B1-601[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK05343.
OMAiRMKANIG.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 3 hits.
InterProiIPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012810. TreS/a-amylase_N.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR02456. treS_nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

I6X8K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEAEHSVEH PPVQGSHVEG GVVEHPDAKD FGSAAALPAD PTWFKHAVFY
60 70 80 90 100
EVLVRAFFDA SADGSGDLRG LIDRLDYLQW LGIDCIWLPP FYDSPLRDGG
110 120 130 140 150
YDIRDFYKVL PEFGTVDDFV ALVDAAHRRG IRIITDLVMN HTSESHPWFQ
160 170 180 190 200
ESRRDPDGPY GDYYVWSDTS ERYTDARIIF VDTEESNWSF DPVRRQFYWH
210 220 230 240 250
RFFSHQPDLN YDNPAVQEAM IDVIRFWLGL GIDGFRLDAV PYLFEREGTN
260 270 280 290 300
CENLPETHAF LKRVRKVVDD EFPGRVLLAE ANQWPGDVVE YFGDPNTGGD
310 320 330 340 350
ECHMAFHFPL MPRIFMAVRR ESRFPISEII AQTPPIPDMA QWGIFLRNHD
360 370 380 390 400
ELTLEMVTDE ERDYMYAEYA KDPRMKANVG IRRRLAPLLD NDRNQIELFT
410 420 430 440 450
ALLLSLPGSP VLYYGDEIGM GDVIWLGDRD GVRIPMQWTP DRNAGFSTAN
460 470 480 490 500
PGRLYLPPSQ DPVYGYQAVN VEAQRDTSTS LLNFTRTMLA VRRRHPAFAV
510 520 530 540 550
GAFQELGGSN PSVLAYVRQV AGDDGDTVLC VNNLSRFPQP IELDLQQWTN
560 570 580 590 600
YTPVELTGHV EFPRIGQVPY LLTLPGHGFY WFQLTTHEVG APPTCGGERR

L
Length:601
Mass (Da):68,593
Last modified:October 3, 2012 - v1
Checksum:iFE52E5258F38116E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN47974.1.
JLDD01000001 Genomic DNA. Translation: KBJ41232.1.
RefSeqiNP_214640.1. NC_000962.3.
YP_006513445.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN47974; AFN47974; RVBD_0126.
GeneIDi13316109.
886881.
KEGGimtu:Rv0126.
mtv:RVBD_0126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN47974.1 .
JLDD01000001 Genomic DNA. Translation: KBJ41232.1 .
RefSeqi NP_214640.1. NC_000962.3.
YP_006513445.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LXF X-ray 2.60 A/B 1-601 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFN47974 ; AFN47974 ; RVBD_0126 .
GeneIDi 13316109.
886881.
KEGGi mtu:Rv0126.
mtv:RVBD_0126.

Phylogenomic databases

KOi K05343.
OMAi RMKANIG.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 3 hits.
InterProi IPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012810. TreS/a-amylase_N.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR02456. treS_nterm. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis of ?-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2."
    Roy R., Usha V., Kermani A., Scott D.J., Hyde E.I., Besra G.S., Alderwick L.J., Futterer K.
    ACS Chem. Biol. 8:2245-2255(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH CALCIUM.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.

Entry informationi

Entry nameiI6X8K8_MYCTU
AccessioniPrimary (citable) accession number: I6X8K8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3