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I6X8K8 (I6X8K8_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region128 – 1292Sulfate 6 binding PDB 4LXF
Region347 – 3504Sulfate 3 binding PDB 4LXF

Sites

Metal binding1401Calcium PDB 4LXF
Metal binding2081Calcium PDB 4LXF
Metal binding2421Calcium; via carbonyl oxygen PDB 4LXF
Metal binding2431Calcium; via carbonyl oxygen PDB 4LXF
Metal binding2451Calcium PDB 4LXF
Binding site421Sulfate 1 PDB 4LXF
Binding site461Sulfate 1 PDB 4LXF
Binding site511Sulfate 2 PDB 4LXF
Binding site511Sulfate 3 PDB 4LXF
Binding site1041Sulfate 4 PDB 4LXF
Binding site1041Sulfate 5 PDB 4LXF
Binding site2361Sulfate 2 PDB 4LXF
Binding site3471Sulfate 2 PDB 4LXF
Binding site3511Sulfate 2; via amide nitrogen PDB 4LXF

Sequences

Sequence LengthMass (Da)Tools
I6X8K8 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: FE52E5258F38116E

FASTA60168,593
        10         20         30         40         50         60 
MNEAEHSVEH PPVQGSHVEG GVVEHPDAKD FGSAAALPAD PTWFKHAVFY EVLVRAFFDA 

        70         80         90        100        110        120 
SADGSGDLRG LIDRLDYLQW LGIDCIWLPP FYDSPLRDGG YDIRDFYKVL PEFGTVDDFV 

       130        140        150        160        170        180 
ALVDAAHRRG IRIITDLVMN HTSESHPWFQ ESRRDPDGPY GDYYVWSDTS ERYTDARIIF 

       190        200        210        220        230        240 
VDTEESNWSF DPVRRQFYWH RFFSHQPDLN YDNPAVQEAM IDVIRFWLGL GIDGFRLDAV 

       250        260        270        280        290        300 
PYLFEREGTN CENLPETHAF LKRVRKVVDD EFPGRVLLAE ANQWPGDVVE YFGDPNTGGD 

       310        320        330        340        350        360 
ECHMAFHFPL MPRIFMAVRR ESRFPISEII AQTPPIPDMA QWGIFLRNHD ELTLEMVTDE 

       370        380        390        400        410        420 
ERDYMYAEYA KDPRMKANVG IRRRLAPLLD NDRNQIELFT ALLLSLPGSP VLYYGDEIGM 

       430        440        450        460        470        480 
GDVIWLGDRD GVRIPMQWTP DRNAGFSTAN PGRLYLPPSQ DPVYGYQAVN VEAQRDTSTS 

       490        500        510        520        530        540 
LLNFTRTMLA VRRRHPAFAV GAFQELGGSN PSVLAYVRQV AGDDGDTVLC VNNLSRFPQP 

       550        560        570        580        590        600 
IELDLQQWTN YTPVELTGHV EFPRIGQVPY LLTLPGHGFY WFQLTTHEVG APPTCGGERR 


L 

« Hide

References

« Hide 'large scale' references
[1]"Synthesis of ?-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2."
Roy R., Usha V., Kermani A., Scott D.J., Hyde E.I., Besra G.S., Alderwick L.J., Futterer K.
ACS Chem. Biol. 8:2245-2255(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH CALCIUM AND SULFATE.
[2]"The genome sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[3]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL AFN47974.1.
[4]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C. expand/collapse author list , Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL KBJ41232.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003248 Genomic DNA. Translation: AFN47974.1.
JLDD01000001 Genomic DNA. Translation: KBJ41232.1.
RefSeqNP_214640.1. NC_000962.3.
YP_006513445.1. NC_018143.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4LXFX-ray2.60A/B1-601[»]
ProteinModelPortalI6X8K8.
SMRI6X8K8. Positions 12-586.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFN47974; AFN47974; RVBD_0126.
GeneID886881.
KEGGmtu:Rv0126.
mtv:RVBD_0126.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK05343.
OMARMKANIG.
PhylomeDBI6X8K8.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 3 hits.
InterProIPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012810. TreS/a-amylase_N.
[Graphical view]
PANTHERPTHR10357. PTHR10357. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
SMARTSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
TIGRFAMsTIGR02456. treS_nterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameI6X8K8_MYCTU
AccessionPrimary (citable) accession number: I6X8K8
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)