ID   I6V105_9EURY            Unreviewed;       622 AA.
AC   I6V105;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=aldehyde ferredoxin oxidoreductase {ECO:0000256|ARBA:ARBA00012818};
DE            EC=1.2.7.5 {ECO:0000256|ARBA:ARBA00012818};
GN   ORFNames=PFC_08775 {ECO:0000313|EMBL:AFN04680.1};
OS   Pyrococcus furiosus COM1.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=1185654 {ECO:0000313|Proteomes:UP000006216};
RN   [1] {ECO:0000313|EMBL:AFN04680.1, ECO:0000313|Proteomes:UP000006216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COM1 {ECO:0000313|EMBL:AFN04680.1,
RC   ECO:0000313|Proteomes:UP000006216};
RX   PubMed=22636780; DOI=10.1128/JB.00439-12;
RA   Bridger S.L., Lancaster W.A., Poole F.L.II., Schut G.J., Adams M.W.;
RT   "Genome Sequencing of a Genetically-Tractable Pyrococcus furiosus Strain
RT   Reveals a Highly Dynamic Genome.";
RL   J. Bacteriol. 194:4097-4106(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC         carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001714};
CC   -!- COFACTOR:
CC       Name=W-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI:60537;
CC         Evidence={ECO:0000256|ARBA:ARBA00001930};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the AOR/FOR family.
CC       {ECO:0000256|ARBA:ARBA00011032}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003685; AFN04680.1; -; Genomic_DNA.
DR   RefSeq; WP_011013103.1; NC_018092.1.
DR   AlphaFoldDB; I6V105; -.
DR   GeneID; 41713783; -.
DR   KEGG; pfi:PFC_08775; -.
DR   PATRIC; fig|1185654.4.peg.1784; -.
DR   HOGENOM; CLU_020364_1_0_2; -.
DR   Proteomes; UP000006216; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2; 1.
DR   Gene3D; 1.10.599.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3; 1.
DR   Gene3D; 3.60.9.10; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   PANTHER; PTHR30038; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR30038:SF0; TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; Aldehyde ferredoxin oxidoreductase, C-terminal domains; 1.
DR   SUPFAM; SSF56228; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Tungsten {ECO:0000256|ARBA:ARBA00023245}.
FT   DOMAIN          4..203
FT                   /note="Aldehyde ferredoxin oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00790"
SQ   SEQUENCE   622 AA;  69369 MW;  C949C9E10DFF5CFC CRC64;
     MFGYKGKIAR VNLTTGKVKY EDLPEEIIRK FIGGKGLGYY IIYKEVPPGT DPLSPANKFV
     FATGGLTGLV PGGSKVIAVS KSPTTRLITD SSGGDAFGPK LKGHFDALII EGRSEEPVYL
     YIHDGKVEIN PAEHLWGKGT YEVAKEIWKD HPSASIAMIG PAGEKMSRMA NVVYDTERAS
     GRGGLGAVLG SKRVKAIVVE PGERPKVAHT EEFQQLWSEF YKKFSTDPKY ADTRKYGTTT
     ALLWAAEVGM GSAYNFSKPH IPEELAKKLS GLEIERYEIE PEWYIHGKSC PIKCSMYMEI
     EYKGKKIRVK PEYESLGMLG AATGVFDLPA VSYFIWLVNN YGLDSIATGN TIAWFLELVE
     RGLITEEEIG FPVKGFGDAE AVERLIHLIA ERKGIGAVLA DGVKRACERL GRGCEFAVHV
     KGLESPAWDP RGRRTYALSY ATADIGASHL RGWPSPHQLP NDGPAKELVP SLIEDRDYMY
     IINMLGVCKF VPYTLDDLAK LYSLATGEEW SVEKLRRVAQ AVESMARIYN ALEWITPPLD
     DTIPPRWWEP EKDGPAKGNA AFIDYNDFLE ARREFYRLRG WDEELGVPLP ETMEKLGYPE
     FKEDAKRALE VVKRRMLNTA LS
//