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I6URY1

- I6URY1_9EURY

UniProt

I6URY1 - I6URY1_9EURY

Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Pyrococcus furiosus COM1
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111NAD; via amide nitrogenUniRule annotation
    Active sitei141 – 1411NucleophileUniRule annotation
    Binding sitei167 – 1671NADUniRule annotation
    Binding sitei298 – 2981NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 132NADUniRule annotation

    GO - Molecular functioni

    1. glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Source: UniProtKB-EC
    2. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro
    4. NADP binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPFUR1185654:GLJ1-1833-MONOMER.
    UniPathwayiUPA00109; UER00184.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.59UniRule annotation)
    Short name:
    GAPDHUniRule annotation
    Alternative name(s):
    NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gapUniRule annotation
    ORF Names:PFC_09215Imported
    OrganismiPyrococcus furiosus COM1Imported
    Taxonomic identifieri1185654 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000006216: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI6URY1.
    SMRiI6URY1. Positions 1-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni140 – 1423Glyceraldehyde 3-phosphate bindingUniRule annotation
    Regioni192 – 1932Glyceraldehyde 3-phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    KOiK00150.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00559. G3P_dehdrog_arch.
    InterProiIPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006436. Glyceraldehyde-3-P_DH_2_arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000149. GAP_DH. 1 hit.
    SMARTiSM00846. Gp_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
    PROSITEiPS00071. GAPDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I6URY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKVGINGY GTIGKRVAYA VTKQDDMELI GVTKTKPDFE AYRAKELGIP    50
    VYAASEEFLP RFEKAGFEVE GTLNDLLEKV DIIVDATPGG MGEKNKQLYE 100
    KAGVKAIFQG GEKAEVAQVS FVAQANYEAA LGKDYVRVVS CNTTGLVRTL 150
    NAIKDYVDYV YAVMIRRAAD PNDIKRGPIN AIKPSVTIPS HHGPDVQTVI 200
    PINIETSAFV VPTTIMHVHS IMVELKKPLT REDVIDIFEN TTRVLLFEKE 250
    KGFESTAQLI EFARDLHREW NNLYEIAVWK ESINVKGNRL FYIQAVHQES 300
    DVIPENIDAI RAMFEIAEKW ESIKKTNKSL GILK 334
    Length:334
    Mass (Da):37,436
    Last modified:October 3, 2012 - v1
    Checksum:i224E0626923AFC66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003685 Genomic DNA. Translation: AFN04766.1.
    RefSeqiWP_011013013.1. NC_018092.1.
    YP_006493058.1. NC_018092.1.

    Genome annotation databases

    EnsemblBacteriaiAFN04766; AFN04766; PFC_09215.
    GeneIDi13301306.
    KEGGipfi:PFC_09215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003685 Genomic DNA. Translation: AFN04766.1 .
    RefSeqi WP_011013013.1. NC_018092.1.
    YP_006493058.1. NC_018092.1.

    3D structure databases

    ProteinModelPortali I6URY1.
    SMRi I6URY1. Positions 1-334.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN04766 ; AFN04766 ; PFC_09215 .
    GeneIDi 13301306.
    KEGGi pfi:PFC_09215.

    Phylogenomic databases

    KOi K00150.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00184 .
    BioCyci PFUR1185654:GLJ1-1833-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00559. G3P_dehdrog_arch.
    InterProi IPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006436. Glyceraldehyde-3-P_DH_2_arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000149. GAP_DH. 1 hit.
    SMARTi SM00846. Gp_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01546. GAPDH-II_archae. 1 hit.
    PROSITEi PS00071. GAPDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome Sequencing of a Genetically-Tractable Pyrococcus furiosus Strain Reveals a Highly Dynamic Genome."
      Bridger S.L., Lancaster W.A., Poole F.L.II., Schut G.J., Adams M.W.
      J. Bacteriol. 194:4097-4106(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: COM1Imported.

    Entry informationi

    Entry nameiI6URY1_9EURY
    AccessioniPrimary (citable) accession number: I6URY1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3